The LexA-RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation.

Autor: Cory MB; Graduate Group in Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA., Li A; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA., Hurley CM; Graduate Group in Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA., Carman PJ; Graduate Group in Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA., Pumroy RA; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA., Hostetler ZM; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Perez RM; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA., Venkatesh Y; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA., Li X; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA., Gupta K; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA., Petersson EJ; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA. ejpetersson@sas.upenn.edu.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA. ejpetersson@sas.upenn.edu., Kohli RM; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA. rkohli@pennmedicine.upenn.edu.; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA. rkohli@pennmedicine.upenn.edu.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2024 Oct; Vol. 31 (10), pp. 1522-1531. Date of Electronic Publication: 2024 May 16.

Kinetic dissection of macromolecular complex formation with minimally perturbing fluorescent probes.

Autor: Cory MB; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Hostetler ZM; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Kohli RM; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Electronic address: rkohli@upenn.edu.

Publikováno v: Methods in enzymology [Methods Enzymol] 2022; Vol. 664, pp. 151-171. Date of Electronic Publication: 2022 Jan 29.

Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response.

Autor: Selwood T; Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, United States., Larsen BJ; Fox Chase Chemical Diversity Center, Inc., Doylestown, PA, United States., Mo CY; Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, United States., Culyba MJ; Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, United States., Hostetler ZM; Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, United States., Kohli RM; Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, United States., Reitz AB; Fox Chase Chemical Diversity Center, Inc., Doylestown, PA, United States., Baugh SDP; Fox Chase Chemical Diversity Center, Inc., Doylestown, PA, United States.

Publikováno v: Frontiers in microbiology [Front Microbiol] 2018 Dec 18; Vol. 9, pp. 2961. Date of Electronic Publication: 2018 Dec 18 (Print Publication: 2018).

Improving the Fluorescent Probe Acridonylalanine Through a Combination of Theory and Experiment.

Autor: Sungwienwong I; Department of Chemistry, University of Pennsylvania, 213 South 34th Street, Philadelphia, PA 19104, USA., Ferrie JJ; Department of Chemistry, University of Pennsylvania, 213 South 34th Street, Philadelphia, PA 19104, USA., Jun JV; Department of Chemistry, University of Pennsylvania, 213 South 34th Street, Philadelphia, PA 19104, USA., Liu C; Department of Chemistry, University of Pennsylvania, 213 South 34th Street, Philadelphia, PA 19104, USA.; Department of Applied Chemistry, China Agricultural University, Yuanmingyuan West Road 2, Beijing 100193, China., Barrett TM; Department of Chemistry, University of Pennsylvania, 213 South 34th Street, Philadelphia, PA 19104, USA., Hostetler ZM; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104, USA., Ieda N; Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabedori, Mizuho-ku, Nagoya-shi, Aichi 467-8603, Japan., Hendricks A; Department of Chemistry, University of Pennsylvania, 213 South 34th Street, Philadelphia, PA 19104, USA.; Department of Applied Chemistry, China Agricultural University, Yuanmingyuan West Road 2, Beijing 100193, China.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104, USA.; Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabedori, Mizuho-ku, Nagoya-shi, Aichi 467-8603, Japan.; Temple University Institute for Computational Molecular Science, 1925 N. 12th St., Philadelphia, PA 19122, USA., Muthusamy AK; Department of Chemistry, University of Pennsylvania, 213 South 34th Street, Philadelphia, PA 19104, USA.; Department of Applied Chemistry, China Agricultural University, Yuanmingyuan West Road 2, Beijing 100193, China.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104, USA.; Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabedori, Mizuho-ku, Nagoya-shi, Aichi 467-8603, Japan.; Temple University Institute for Computational Molecular Science, 1925 N. 12th St., Philadelphia, PA 19122, USA., Kohli RM; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104, USA., Chenoweth DM; Department of Chemistry, University of Pennsylvania, 213 South 34th Street, Philadelphia, PA 19104, USA., Petersson GA; Temple University Institute for Computational Molecular Science, 1925 N. 12th St., Philadelphia, PA 19122, USA., Petersson EJ; Department of Chemistry, University of Pennsylvania, 213 South 34th Street, Philadelphia, PA 19104, USA.

Publikováno v: Journal of physical organic chemistry [J Phys Org Chem] 2018 Aug; Vol. 31 (8). Date of Electronic Publication: 2018 Feb 22.

Improving target amino acid selectivity in a permissive aminoacyl tRNA synthetase through counter-selection.

Autor: Sungwienwong I; Department of Chemistry, University of Pennsylvania, 213 South 34th Street, Philadelphia, PA 19104, USA. ejpetersson@sas.upenn.edu., Hostetler ZM, Blizzard RJ, Porter JJ, Driggers CM, Mbengi LZ, Villegas JA, Speight LC, Saven JG, Perona JJ, Kohli RM, Mehl RA, Petersson EJ

Publikováno v: Organic & biomolecular chemistry [Org Biomol Chem] 2017 May 03; Vol. 15 (17), pp. 3603-3610.