Zobrazeno 1 - 10
of 384
pro vyhledávání: '"Host cell cytosol"'
Publikováno v:
Nature microbiology, vol 6, iss 11
Nat Microbiol
Nat Microbiol
Bluetongue virus (BTV) is a non-enveloped virus and causes substantial morbidity and mortality in ruminants such as sheep. Fashioning a receptor-binding protein (VP2) and a membrane penetration protein (VP5) on the surface, BTV releases its genome-co
Autor:
Matthias Paulus Wagner, Pauline Formaglio, Olivier Gorgette, Jerzy Michal Dziekan, Christèle Huon, Isabell Berneburg, Stefan Rahlfs, Jean-Christophe Barale, Sheldon I. Feinstein, Aron B. Fisher, Didier Ménard, Zbynek Bozdech, Rogerio Amino, Lhousseine Touqui, Chetan E. Chitnis
Publikováno v:
Cell Reports
Cell Reports, 2022, 39 (11), pp.110923. ⟨10.1016/j.celrep.2022.110923⟩
Cell Reports, 2022, 39 (11), pp.110923. ⟨10.1016/j.celrep.2022.110923⟩
The uptake and digestion of host hemoglobin by malaria parasites during blood-stage growth leads to significant oxidative damage of membrane lipids. Repair of lipid peroxidation damage is crucial for parasite survival. Here, we demonstrate that Plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cee356e4b5a022e52e6a9cec3b607c8
https://doi.org/10.1101/2022.04.11.487889
https://doi.org/10.1101/2022.04.11.487889
Autor:
Victoria Lovins, Elin Movert, Esther Nobs, Christine Valfridsson, Fredric Carlsson, Julia Lienard
Publikováno v:
Proceedings of the National Academy of Sciences. 117:1160-1166
Following mycobacterial entry into macrophages the ESX-1 type VII secretion system promotes phagosomal permeabilization and type I IFN production, key features of tuberculosis pathogenesis. The current model states that the secreted substrate ESAT-6
Autor:
Ludovic Pilloux, C. Kebbi-Beghdadi, Antony Croxatto, N. Tosetti, Trestan Pillonel, Gilbert Greub
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific reports, vol. 9, no. 1, pp. 19485
Scientific Reports
Scientific reports, vol. 9, no. 1, pp. 19485
Waddlia chondrophila is an intracellular bacterium phylogenetically related to the well-studied human and animal pathogens of the Chlamydiaceae family. In the last decade, W. chondrophila was convincingly demonstrated to be associated with adverse pr
Autor:
Rachid Zagani, Yun Zhao, Sung-Moo Park, Hans Christian Reinecker, Naohiro Yoshida, Tatsushi Omatsu, Pankaj Shah
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-15 (2019)
The innate immune response following infection with entero-invasive bacterial species is triggered upon release of cyclic di-guanylate monophosphate (c-di-GMP) into the host cell cytosol. Bacterial c-di-GMP activates the intracellular Sensor Stimulat
Autor:
Matthew D. Welch, Patrik Engström, Michael Rape, Kevin G. Mark, Nadia Ingabire, Anthony T. Iavarone, Guillaume Golovkine, Gabriel Mitchell, Thomas P. Burke, Jeffery S. Cox
Publikováno v:
Nature microbiology
Rickettsia are obligate intracellular bacteria that evade antimicrobial autophagy in the host cell cytosol by unknown mechanisms. Other cytosolic pathogens block different steps of autophagy targeting, including the initial step of polyubiquitin-coat
Autor:
Sunny Shin, Xin Liu
Publikováno v:
J Mol Biol
Legionella pneumophila is the causative agent of the severe pneumonia Legionnaires' disease. L. pneumophila is ubiquitously found in freshwater environments, where it replicates within free-living protozoa. Aerosolization of contaminated water suppli
Publikováno v:
Current Opinion in Immunology. 60:63-70
Inflammasomes are a formidable armada of intracellular pattern recognition receptors. They recognize determinants of infection, such as foreign entities or danger signals within the host cell cytosol, rapidly executing innate immune defenses and init
Autor:
Stephanie A Ragland, Jonathan C. Kagan
Publikováno v:
Mol Microbiol
The metazoan innate immune system senses bacterial infections by detecting highly conserved bacterial molecules, termed pathogen-associated molecular patterns (PAMPs). PAMPs are detected by a variety of host pattern recognition receptors (PRRs), whos
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Currently, the COVID-19 pandemic is an international challenge, largely due to lack of effective therapies. Pharmacotherapy has not yet been able to find a definitive treatment for COVID-19. Since SARS-CoV-2 affects several organs, treatment strategi