Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Hossam A, Abdelsamed"'
Autor:
Silvia Liu, Alan F. Zahorchak, Steven F. Dobrowolski, Diana M. Metes, Angus W. Thomson, Hossam A. Abdelsamed
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract During differentiation of precursor cells into their destination cell type, cell fate decisions are enforced by a broad array of epigenetic modifications, including DNA methylation, which is reflected by the transcriptome. Thus, regulatory d
Externí odkaz:
https://doaj.org/article/792445a8ea6e476e856df477eeebc201
Autor:
Mohammed Yosri, Mohamed Dokhan, Elizabeth Aboagye, Mouhamad Al Moussawy, Hossam A. Abdelsamed
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The immune system is endowed with the capacity to distinguish between self and non-self, so-called immune tolerance or “consciousness of the immune system.” This type of awareness is designed to achieve host protection by eliminating cells expres
Externí odkaz:
https://doaj.org/article/8a47982654534e35bbbf79b38bcff712
Autor:
Kazuki Sasaki, Mouhamad Al Moussawy, Khodor I. Abou-Daya, Camila Macedo, Amira Hosni-Ahmed, Silvia Liu, Mariam Juya, Alan F. Zahorchak, Diana M. Metes, Angus W. Thomson, Fadi G. Lakkis, Hossam A. Abdelsamed
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Human activated memory CD8 T cells develop a non-cytotoxic function and influence the fate of autologous naïve CD8 T cells where they acquire an activated/memory state and a hybrid state between naïve and activated memory.
Externí odkaz:
https://doaj.org/article/44b4b05e7ad3482c93e236ebb6b01b84
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cytotoxic CD8 T cells (CTLs) are classically described as the “serial killers” of the immune system, where they play a pivotal role in protective immunity against a wide spectrum of pathogens and tumors. Ironically, they are critical drivers of t
Externí odkaz:
https://doaj.org/article/2686035d77314bd7b8301c18fa22b8cb
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Memory CD8 T cells have a unique ability to provide lifelong immunity against pathogens containing their cognate epitope. Because of their ability to provide lifelong protection, the generation of memory T cells is now a major focus for current vacci
Externí odkaz:
https://doaj.org/article/63264f332ef64511b5c739b3edcf7860
Autor:
Kazuki Saski, Mouhamad Al Moussawy, Khodor I. Abou-Daya, Camila. Macedo, Amira Hosni-Ahmed, Silvia Liu, Mariam Juya, Alan F. Zahorchak, Diana M. Metes, Angus W. Thomson, Fadi G. Lakkis, Hossam A. Abdelsamed
T cells are endowed with the capacity to sense their environment including other T cells around them. They do so to set their numbers and activation thresholds. This form of regulation has been well-studied within a given T cell population – i.e.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de40d661943f1e77330bb2411af83b6c
https://doi.org/10.21203/rs.3.rs-1651269/v1
https://doi.org/10.21203/rs.3.rs-1651269/v1
Autor:
Rafick-Pierre Sekaly, Elisavet Serti, Shannon K. Boi, Ashley H. Castellaw, Dietmar Zehn, Hai Nguyen, Hazem E. Ghoneim, Caitlin C. Zebley, Michael E. Busch, Mars Stone, Rachel L. Rutishauser, Francesca Alfei, Eddie A. James, Maureen A. McGargill, Cate Speake, Ben Youngblood, Jeremy Chase Crawford, Yiping Fan, Gerald T. Nepom, Steven G. Deeks, Hossam A. Abdelsamed, Susan Pereira Ribeiro, Shanta Alli, Hongjian Jin, Laurence A. Turka
Publikováno v:
Nature immunology
Nature immunology, vol 21, iss 5
Nature Immunology
Nature immunology, vol 21, iss 5
Nature Immunology
The pool of beta cell-specific CD8+ T cells in type 1 diabetes (T1D) sustains an autoreactive potential despite having access to a constant source of antigen. To investigate the long-lived nature of these cells, we established a DNA methylation-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c766e2ff25c8b1dacf4caad1134276
http://europepmc.org/articles/PMC7183435
http://europepmc.org/articles/PMC7183435
Autor:
Hossam A. Abdelsamed, Fadi G. Lakkis
Publikováno v:
J Clin Invest
While direct allorecognition underpins both solid organ allograft rejection and tolerance induction, the specific molecular targets of most directly alloreactive CD8(+) T cells have not been defined. In this study, we used a combination of geneticall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82f14d9bec3aefbc0b6ee622803e1bd
https://europepmc.org/articles/PMC8553548/
https://europepmc.org/articles/PMC8553548/
Publikováno v:
Immunogenetics
Host immunity is classically divided into “innate” and “adaptive.” While the former has always been regarded as the first, rapid, and antigen-nonspecific reaction to invading pathogens, the latter represents the more sophisticated and antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1466c885e5b20e870d2bfb7a85ef02
https://pubmed.ncbi.nlm.nih.gov/35034136
https://pubmed.ncbi.nlm.nih.gov/35034136
Autor:
Adolfo B Frias, Rachel L Rutishauser, Ashish Arunkumar Sharma, Tian Mi, Hossam Aly Abdelsamed, Caitlin Zebley, Christian M Constantz, Mars Stone, Michael Busch, Steven Deeks, Rafick Sekaly, Ben A Youngblood
Publikováno v:
The Journal of Immunology. 208:182.07-182.07
CD8 T cells from HIV infected ‘elite controllers’ maintain long-lived protective properties including enhanced cytokine production and proliferative capacity over many years. With the advent of adoptive cellular therapy to treat chronic diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3f2477dc5f0c1bf1b72ca5eff16e7c9
https://doi.org/10.4049/jimmunol.208.supp.182.07
https://doi.org/10.4049/jimmunol.208.supp.182.07