Effects of empagliflozin on progression of chronic kidney disease: a prespecified secondary analysis from the empa-kidney trial

Autor: Staplin, N, Haynes, R ^*, Judge, PK, Wanner, C, Green, JB, Emberson, J, Preiss, D, Mayne, KJ, Ng, SYA, Sammons, E, Zhu, D, Hill, M, Stevens, W, Wallendszus, K, Brenner, S, Cheung, AK, Liu, ZH, Li, J, Hooi, LS, Liu, WJ, Kadowaki, T, Nangaku, M, Levin, A, Cherney, D, Maggioni, AP, Pontremoli, R, Deo, R, Goto, S, Rossello, X, Tuttle, KR, Steubl, D, Petrini, M, Seidi, S, Landray, MJ, Baigent, C, Herrington, WG, Abat, S, Abd Rahman, R, Abdul Cader, R, Abdul Hafidz, MI, Abdul Wahab, MZ, Abdullah, NK, Abdul-Samad, T, Abe, M, Abraham, N, Acheampong, S, Achiri, P, Acosta, JA, Adeleke, A, Adell, V, Adewuyi-Dalton, R, Adnan, N, Africano, A, Agharazii, M, Aguilar, F, Aguilera, A, Ahmad, M, Ahmad, MK, Ahmad, NA, Ahmad, NH, Ahmad, NI, Ahmad Miswan, N, Ahmad Rosdi, H, Ahmed, I, Ahmed, S, Aiello, J, Aitken, A, AitSadi, R, Aker, S, Akimoto, S, Akinfolarin, A, Akram, S, Alberici, F, Albert, C, Aldrich, L, Alegata, M, Alexander, L, Alfaress, S, Alhadj Ali, M, Ali, A, Alicic, R, Aliu, A, Almaraz, R, Almasarwah, R, Almeida, J, Aloisi, A, Al-Rabadi, L, Alscher, D, Alvarez, P, Al-Zeer, B, Amat, M, Ambrose, C, Ammar, H, An, Y, Andriaccio, L, Ansu, K, Apostolidi, A, Arai, N, Araki, H, Araki, S, Arbi, A, Arechiga, O, Armstrong, S, Arnold, T, Aronoff, S, Arriaga, W, Arroyo, J, Arteaga, D, Asahara, S, Asai, A, Asai, N, Asano, S, Asawa, M, Asmee, MF, Aucella, F, Augustin, M, Avery, A, Awad, A, Awang, IY, Awazawa, M, Axler, A, Ayub, W, Azhari, Z, Baccaro, R, Badin, C, Bagwell, B, Bahlmann-Kroll, E, Bahtar, AZ, Bains, D, Bajaj, H, Baker, R, Baldini, E, Banas, B, Banerjee, D, Banno, S, Bansal, S, Barberi, S, Barnes, S, Barnini, C, Barot, C, Barrett, K, Barrios, R, Bartolomei Mecatti, B, Barton, I, Barton, J, Basily, W, Bavanandan, S, Baxter, A, Becker, L, Beddhu, S, Beige, J, Beigh, S, Bell, S, Benck, U, Beneat, A, Bennett, A, Bennett, D, Benyon, S, Berdeprado, J, Bergler, T, Bergner, A, Berry, M, Bevilacqua, M, Bhairoo, J, Bhandari, S, Bhandary, N, Bhatt, A, Bhattarai, M, Bhavsar, M, 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Publikováno v: In The Lancet Diabetes & Endocrinology January 2024 12(1):39-50

Downregulation of Krüppel-like factor 15 expression delays endochondral bone ossification during fracture healing.

Autor: Tachibana S; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Hayashi S; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan. Electronic address: shayashi@med.kobe-u.ac.jp., Ikuta K; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Anjiki K; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Onoi Y; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Suda Y; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Wada K; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Maeda T; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Saito A; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Tsubosaka M; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Kamenaga T; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Kuroda Y; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Nakano N; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Matsumoto T; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Hosooka T; Laboratory of Nutritional Physiology, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan., Ogawa W; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan., Kuroda R; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Publikováno v: Bone [Bone] 2025 Jan; Vol. 190, pp. 117302. Date of Electronic Publication: 2024 Oct 20.

Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism.

Autor: Nomura K; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 17177, Sweden., Kinoshita S; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan., Mizusaki N; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan., Senga Y; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan., Sasaki T; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan., Kitamura T; Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8512, Japan., Sakaue H; Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan; Diabetes Therapeutics and Research Center, University of Tokushima, Tokushima 770-8503, Japan., Emi A; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan., Hosooka T; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; Laboratory of Nutritional Physiology, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 422-8526, Japan., Matsuo M; Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan., Okamura H; Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan; Department of Neuroscience, Graduate School of Medicine, Kyoto University, Kyoto 606-8303, Japan., Amo T; Department of Applied Chemistry, National Defense Academy, Yokosuka 239-8686, Japan., Wolf AM; Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nippon Medical School, Kawasaki 211-8533, Japan., Kamimura N; Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nippon Medical School, Kawasaki 211-8533, Japan; Laboratory for Clinical Research, Collaborative Research Center, Nippon Medical School, Tokyo 113-8602, Japan., Ohta S; Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nippon Medical School, Kawasaki 211-8533, Japan., Itoh T; Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan., Hayashi Y; Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan., Kiyonari H; Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan., Krook A; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 17177, Sweden., Zierath JR; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 17177, Sweden., Kasuga M; The Institute of Medical Science, Asahi Life Foundation, Tokyo 100-0005, Japan., Ogawa W; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. Electronic address: ogawa@med.kobe-u.ac.jp.

Publikováno v: Molecular metabolism [Mol Metab] 2024 Aug; Vol. 86, pp. 101968. Date of Electronic Publication: 2024 Jun 15.

Thrombospondin-1 promotes liver fibrosis by enhancing TGF-β action in hepatic stellate cells.

Autor: Imamori M; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan., Hosooka T; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan; Laboratory of Nutritional Physiology, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Suruga-ku, Shizuoka, 422-8526, Japan. Electronic address: thosooka@u-shizuoka-ken.ac.jp., Imi Y; Laboratory of Nutritional Physiology, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Suruga-ku, Shizuoka, 422-8526, Japan., Hosokawa Y; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan., Yamaguchi K; Division of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, 602-8566, Japan., Itoh Y; Division of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, 602-8566, Japan., Ogawa W; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Jan 22; Vol. 693, pp. 149369. Date of Electronic Publication: 2023 Dec 10.

A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cells.

Autor: Kasahara N; Laboratory of Nutritional Physiology, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-Ku, Shizuoka, 422-8526, Japan., Imi Y; Laboratory of Nutritional Physiology, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-Ku, Shizuoka, 422-8526, Japan., Amano R; Laboratory of Nutritional Physiology, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-Ku, Shizuoka, 422-8526, Japan., Shinohara M; Division of Molecular Epidemiology, Department of Future Medicine Sciences, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan.; The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan., Okada K; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan., Hosokawa Y; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan., Imamori M; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan., Tomimoto C; Noster Inc., Muko-Shi, Kyoto, 617-0006, Japan., Kunisawa J; Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health, and Nutrition (NIBIOHN), Osaka, 567-0085, Japan., Kishino S; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo-Ku, Kyoto, 606-8502, Japan., Ogawa J; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo-Ku, Kyoto, 606-8502, Japan., Ogawa W; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan., Hosooka T; Laboratory of Nutritional Physiology, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-Ku, Shizuoka, 422-8526, Japan. thosooka@u-shizuoka-ken.ac.jp.; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan. thosooka@u-shizuoka-ken.ac.jp.; Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health, and Nutrition (NIBIOHN), Osaka, 567-0085, Japan. thosooka@u-shizuoka-ken.ac.jp.

Publikováno v: Scientific reports [Sci Rep] 2023 Nov 03; Vol. 13 (1), pp. 18983. Date of Electronic Publication: 2023 Nov 03.