Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hosios, Aaron Marc"'
Autor:
Lunt, Sophia Y., Muralidhar, Vinayak, Israelsen, William J., Newhouse, Lauren, Ogrodzinski, Martin, Xu, Kali, Hollern, Daniel P., Bellinger, Gary, Christen, Stefan, Elia, Ilaria, Dinh, Anh T., Stephanopoulos, Gregory, Manalis, Scott R., Yaffe, Michael B., Andrechek, Eran R., Fendt, Sarah-Maria, Vander Heiden, Matthew G., Hosios, Aaron Marc, Gui, Dan Yi, Acevedo, Paula N. Marin, Dayton, Talya Lucia, Manalis, Scott R, Yaffe, Michael B, Hecht, Vivian Chaya
Publikováno v:
PMC
Metabolic regulation influences cell proliferation. The influence of pyruvate kinase isoforms on tumor cells has been extensively studied, but whether PKM2 is required for normal cell proliferation is unknown. We examine how PKM2 deletion affects pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fc3381c20adef7d01a1c669923144b
https://pubmed.ncbi.nlm.nih.gov/25482511
https://pubmed.ncbi.nlm.nih.gov/25482511
Autor:
Brian W. Ji, Alexander Muir, Margaret E. Torrence, Matthew R. Bauer, Allison N. Lau, Brian M. Wolpin, Aaron M. Hosios, Matthew G. Vander Heiden, Thales Papagiannakopoulos, Dennis Vitkup, Purushottam D. Dixit, Laura V. Danai, Christopher R. Chin, Elizaveta Freinkman, Tyler Jacks, Jared R. Mayers, Shawn M. Davidson
Publikováno v:
PMC
Tumor genetics guides patient selection for many new therapies, and cell culture studies have demonstrated that specific mutations can promote metabolic phenotypes. However, whether tissue context defines cancer dependence on specific metabolic pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a83fee2f1b3aa59aeeed9c3c6cc59f
https://doi.org/10.1126/science.aaf5171
https://doi.org/10.1126/science.aaf5171
Publikováno v:
PMC
The role of pyruvate kinase M2 (PKM2) in cell proliferation is controversial. A unique function of PKM2 proposed to be important for the proliferation of some cancer cells involves the direct activity of this enzyme as a protein kinase; however, a de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7d16bddfcefd5711cf117363e1f3ce
https://doi.org/10.1016/j.molcel.2015.07.013
https://doi.org/10.1016/j.molcel.2015.07.013
PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells
Autor:
Lewis C. Cantley, Jie Li, Gary Bellinger, Aaron M. Hosios, Michael J. Jurczak, Dolores Di Vizio, Gordon B. Mills, Yimin Yu, Mika Sasaki, James W. Horner, Richard G. Kibbey, Shawn M. Davidson, Clary B. Clish, Laura N. Burga, Jianxin Xie, Talya L. Dayton, Brian P. Fiske, Matthew G. Vander Heiden, Tyler Jacks, Ronald A. DePinho, Gerburg M. Wulf, William J. Israelsen
Publikováno v:
PMC
The pyruvate kinase M2 isoform (PKM2) is expressed in cancer and plays a role in regulating anabolic metabolism. To determine whether PKM2 is required for tumor formation or growth, we generated mice with a conditional allele that abolishes PKM2 expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181e1b1bf2fdcfaf94af62c544330152
Autor:
Jeffrey C. Rathmell, Vivian C. Hecht, Laura V. Danai, Matthew G. Vander Heiden, Scott R. Manalis, Matthew L. Steinhauser, Marc O. Johnson, Aaron M. Hosios
Publikováno v:
PMC
Cells must duplicate their mass in order to proliferate. Glucose and glutamine are the major nutrients consumed by proliferating mammalian cells, but the extent to which these and other nutrients contribute to cell mass is unknown. We quantified the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e29704c9c05644e73c5be9e1d375e5
http://hdl.handle.net/1721.1/116920
http://hdl.handle.net/1721.1/116920
Autor:
Lawrence D. Schweitzer, Yao-Chung Weng, Mark M. Stevens, Kris C. Wood, Aaron M. Hosios, Hui Xiao Chao, Scott R. Manalis, Carson C. Thoreen, David M. Sabatini, Sungmin Son, Matthew G. Vander Heiden
Publikováno v:
Nature Publishing Group
Scientific Reports
Scientific Reports
The coordination of metabolic processes to allow increased nutrient uptake and utilization for macromolecular synthesis is central for cell growth. Although studies of bulk cell populations have revealed important metabolic and signaling requirements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adbb7ba33c956872e4c4ada755104580
https://orcid.org/0000-0002-5702-8667
https://orcid.org/0000-0002-5702-8667
Autor:
Nadege Gitego, Aaron M. Hosios, Matthew G. Vander Heiden, Craig J. Thomas, Shawn M. Davidson, Lauren N. Bush, Dan Y. Gui, Alba Luengo, Lucas B. Sullivan, Elizaveta Freinkman
Publikováno v:
PMC
Metformin use is associated with reduced cancer mortality, but how metformin impacts cancer outcomes is controversial. Although metformin can act on cells autonomously to inhibit tumor growth, the doses of metformin that inhibit proliferation in tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da69b91ec71f501528b53cec4c743571
https://pubmed.ncbi.nlm.nih.gov/27746050
https://pubmed.ncbi.nlm.nih.gov/27746050