Adenosine signalling to astrocytes coordinates brain metabolism and function.

Autor: Theparambil SM; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK. s.theparambil@ucl.ac.uk.; Department of Biomedical and Life Sciences, Lancaster University, Lancaster, UK. s.theparambil@ucl.ac.uk., Kopach O; Institute of Neurology, University College London, London, UK., Braga A; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK., Nizari S; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK., Hosford PS; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK., Sagi-Kiss V; Section of Bioanalytical Chemistry, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Hadjihambi A; The Roger Williams Institute of Hepatology, Foundation for Liver Research & Faculty of Life Sciences and Medicine, King's College London, London, UK., Konstantinou C; The Roger Williams Institute of Hepatology, Foundation for Liver Research & Faculty of Life Sciences and Medicine, King's College London, London, UK., Esteras N; Institute of Neurology, University College London, London, UK., Gutierrez Del Arroyo A; Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK., Ackland GL; Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK., Teschemacher AG; Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol, UK., Dale N; School of Life Sciences, University of Warwick, Coventry, UK., Eckle T; Department of Anesthesiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Andrikopoulos P; Section of Biomolecular Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Rusakov DA; Institute of Neurology, University College London, London, UK., Kasparov S; Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol, UK., Gourine AV; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK. a.gourine@ucl.ac.uk.

Publikováno v: Nature [Nature] 2024 Aug; Vol. 632 (8023), pp. 139-146. Date of Electronic Publication: 2024 Jul 03.

Astrocytes produce nitric oxide via nitrite reduction in mitochondria to regulate cerebral blood flow during brain hypoxia.

Autor: Christie IN; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, UK., Theparambil SM; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, UK. Electronic address: s.theparambil@ucl.ac.uk., Braga A; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, UK., Doronin M; College of Medicine, Jiaxing University, Jiaxing 314001, China., Hosford PS; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, UK., Brazhe A; Department of Molecular Neurobiology, Institute of Bioorganic Chemistry, Moscow 117997, Russian Federation; Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russian Federation., Mascarenhas A; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, UK., Nizari S; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, UK; Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London WC1E 6BT, UK., Hadjihambi A; The Roger Williams Institute of Hepatology, Foundation for Liver Research, and Faculty of Life Sciences and Medicine, King's College London, London SE5 9NT, UK., Wells JA; Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London WC1E 6BT, UK., Hobbs A; William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK., Semyanov A; College of Medicine, Jiaxing University, Jiaxing 314001, China; Department of Molecular Neurobiology, Institute of Bioorganic Chemistry, Moscow 117997, Russian Federation., Abramov AY; Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Angelova PR; Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Gourine AV; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, UK. Electronic address: a.gourine@ucl.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2023 Dec 26; Vol. 42 (12), pp. 113514. Date of Electronic Publication: 2023 Nov 30.

Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction.

Autor: Hadjihambi A; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland; The Roger Williams Institute of Hepatology London, Foundation for Liver Research, London, UK; Faculty of Life Sciences and Medicine, King's College London, London, UK. Electronic address: a.hadjichambi@researchinliver.org.uk., Konstantinou C; The Roger Williams Institute of Hepatology London, Foundation for Liver Research, London, UK; Faculty of Life Sciences and Medicine, King's College London, London, UK., Klohs J; Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland; Neuroscience Centre Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland., Monsorno K; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Le Guennec A; NMR Facility, Guy's Campus, King's College London, London, UK., Donnelly C; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland; Institute of Sports Science, University of Lausanne, Lausanne, Switzerland., Cox IJ; The Roger Williams Institute of Hepatology London, Foundation for Liver Research, London, UK; Faculty of Life Sciences and Medicine, King's College London, London, UK., Kusumbe A; Tissue and Tumor Microenvironments Group, MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Hosford PS; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK., Soffientini U; The Roger Williams Institute of Hepatology London, Foundation for Liver Research, London, UK; Faculty of Life Sciences and Medicine, King's College London, London, UK., Lecca S; The Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland., Mameli M; The Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland; Inserm, UMR-S 839, Paris, France., Jalan R; Institute for Liver and Digestive Health, Division of Medicine, UCL Medical School, Royal Free Hospital, University College London, London, UK., Paolicelli RC; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Pellerin L; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland; Inserm U1313, Université de Poitiers et CHU de Poitiers, France. Electronic address: luc.pellerin@univ-poitiers.fr.

Publikováno v: Journal of hepatology [J Hepatol] 2023 Jan; Vol. 78 (1), pp. 180-190. Date of Electronic Publication: 2022 Aug 19.

Cerebral perfusion in untreated, controlled, and uncontrolled hypertension.

Autor: Christie IN; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK., Windsor R; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK., Mutsaerts HJ; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., Tillin T; MRC Unit for Lifelong Health & Ageing, Population Science & Experimental Medicine, Faculty of Population Health Sciences, University College London, London, UK., Sudre CH; MRC Unit for Lifelong Health & Ageing, Population Science & Experimental Medicine, Faculty of Population Health Sciences, University College London, London, UK., Hughes AD; Institute of Cardiovascular Science, Population Science & Experimental Medicine, Faculty of Population Health Sciences, University College London, London, UK., Golay X; Queen Square Institute of Neurology, University College London, London, UK., Gourine AV; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK., Hosford PS; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK.

Publikováno v: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2022 Dec; Vol. 42 (12), pp. 2188-2190. Date of Electronic Publication: 2022 Sep 13.

CO 2 signaling mediates neurovascular coupling in the cerebral cortex.

Autor: Hosford PS; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK. p.hosford@ucl.ac.uk., Wells JA; UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK., Nizari S; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK., Christie IN; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK., Theparambil SM; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK., Castro PA; Centro de Estudios Científicos (CECs) & Universidad San Sebastián, Valdivia, Chile.; Universidad Austral de Chile, Valdivia, Chile., Hadjihambi A; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK., Barros LF; Centro de Estudios Científicos (CECs) & Universidad San Sebastián, Valdivia, Chile., Ruminot I; Centro de Estudios Científicos (CECs) & Universidad San Sebastián, Valdivia, Chile. iruminot@cecs.cl., Lythgoe MF; UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK., Gourine AV; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK. a.gourine@ucl.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2022 Apr 19; Vol. 13 (1), pp. 2125. Date of Electronic Publication: 2022 Apr 19.