AKT2-mediated lysosomal dysfunction promotes secretory autophagy in retinal pigment epithelium (RPE) cells.

Autor: Ghosh S; Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Hose S; Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sinha D; Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Publikováno v: Autophagy [Autophagy] 2024 Oct 16, pp. 1-2. Date of Electronic Publication: 2024 Oct 16.

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD.

Autor: Ghosh S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sharma R; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Bammidi S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Koontz V; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Nemani M; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Yazdankhah M; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Kedziora KM; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Stolz DB; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Wallace CT; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Yu-Wei C; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Franks J; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Bose D; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Shang P; Doheny Eye Institute, Pasadena, CA, USA., Ambrosino HM; Doheny Eye Institute, Pasadena, CA, USA., Dutton JR; Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA., Geng Z; Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA., Montford J; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Ryu J; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Rajasundaram D; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hose S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sahel JA; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Institut De La Vision, INSERM, CNRS, Sorbonne Université, Paris, France., Puertollano R; Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Finkel T; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Zigler JS Jr; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sergeev Y; Protein Biochemistry & Molecular Modeling Group, National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Watkins SC; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Goetzman ES; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ferrington DA; Doheny Eye Institute, Pasadena, CA, USA.; Department of Ophthalmology, University of California Los Angeles, Los Angeles, CA, USA., Flores-Bellver M; Department of Ophthalmology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Kaarniranta K; Department of Ophthalmology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.; Department of Molecular Genetics, University of Lodz, Lodz, Poland., Sodhi A; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bharti K; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA. kapil.bharti@nih.gov., Handa JT; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. jthanda@jhmi.edu., Sinha D; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Debasish@pitt.edu.; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Debasish@pitt.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Jul 21; Vol. 15 (1), pp. 6150. Date of Electronic Publication: 2024 Jul 21.

Mitophagy in Astrocytes Is Required for the Health of Optic Nerve.

Autor: Yazdankhah M; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Ghosh S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Liu H; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Hose S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Zigler JS Jr; Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Sinha D; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Publikováno v: Cells [Cells] 2023 Oct 20; Vol. 12 (20). Date of Electronic Publication: 2023 Oct 20.

Aberrant Akt2 signaling in the RPE may contribute to retinal fibrosis process in diabetic retinopathy.

Autor: Daley R; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Maddipatla V; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ghosh S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Chowdhury O; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hose S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Zigler JS Jr; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sinha D; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Debasish@pitt.edu.; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Debasish@pitt.edu., Liu H; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. hal140@pitt.edu.

Publikováno v: Cell death discovery [Cell Death Discov] 2023 Jul 13; Vol. 9 (1), pp. 243. Date of Electronic Publication: 2023 Jul 13.

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD.

Autor: Gupta U; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ghosh S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Wallace CT; Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Shang P; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Xin Y; Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Nair AP; GROW Laboratory, Narayana Nethralaya Foundation, Bengaluru, India., Yazdankhah M; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Strizhakova A; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ross MA; Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Liu H; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hose S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Stepicheva NA; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Chowdhury O; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Nemani M; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Maddipatla V; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Grebe R; Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Das M; Molecular Immunology, Mazumdar Shaw Medical Foundation, Bengaluru, India., Lathrop KL; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, USA., Sahel JA; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Institut De La Vision, INSERM, CNRS, Sorbonne Université, Paris, France., Zigler JS Jr; Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Qian J; Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ghosh A; GROW Laboratory, Narayana Nethralaya Foundation, Bengaluru, India., Sergeev Y; National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Handa JT; Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., St Croix CM; Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sinha D; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Publikováno v: Autophagy [Autophagy] 2023 Jan; Vol. 19 (1), pp. 92-111. Date of Electronic Publication: 2022 Apr 26.