Zobrazeno 1 - 10 of 42 pro vyhledávání: '"Hosahalli P. Hemantha"'
1
Synthetic Uncleavable Ubiquitinated Proteins Dissect Proteasome Deubiquitination and Degradation, and Highlight Distinctive Fate of Tetraubiquitin
Autor: Sumeet K. Singh, Ashraf Brik, Michael H. Glickman, Oded Kleifeld, Sachitanand M. Mali, Hosahalli P. Hemantha, Indrajit Sahu
Publikováno v: Journal of the American Chemical Society. 138:16004-16015
Various hypotheses have been proposed regarding how chain length, linkage type, position on substrate, and susceptibility to deubiquitinases (DUBs) affect processing of different substrates by proteasome. Here we report a new strategy for the chemica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e496580589e6408990ff6931175853
https://doi.org/10.1021/jacs.6b09611
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2
An unambiguous and practical synthesis of Oroxylin A: a commonly misidentified flavone
Autor: Hosahalli P. Hemantha, Rajendran Ramanujam, Muhammed Majeed, Kalyanam Nagabhushanam
Oroxylin A, a major flavonoid in the extracts of Oroxylum indicum as well as Scutellaria baicalensis possesses useful medicinal properties. Many of the published routes claiming the synthesis of Oroxylin A (1) have in fact led to a regioisomer Neglet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0c5925194daf9aaed753f1a7521fc6
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3
Chemical Synthesis of Ubiquitin Chains
Autor: Ashraf Brik, Sumeet K. Singh, Somasekhar Bondalapati, Hosahalli P. Hemantha
Publikováno v: Current Protocols in Chemical Biology
Chemical synthesis of complex biomolecules such as proteins is a challenging adventure, yet rewarding in driving various biochemical and biophysical research activities. Over the years, the refinement of peptide synthesis and invention of ligation me
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685d9c4fbd0306ca185f3a3ddeac1f49
https://doi.org/10.1002/9780470559277.ch150099
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6
Modifying the Vicinity of the Isopeptide Bond To Reveal Differential Behavior of Ubiquitin Chains with Interacting Proteins: Organic Chemistry Applied to Synthetic Proteins
Autor: Carlos A. Castañeda, Muhammad Jbara, Marlin Penner, Hosahalli P. Hemantha, Aaron Ciechanover, Ashraf Brik, David Fushman, Najat Haj-Yahya, Mahmood Haj-Yahya, Liat Spasser
Publikováno v: Angewandte Chemie International Edition. 52:11149-11153
In Every Direction Chemical synthesis of proteins allowed the synthesis of ubiquitin chains modified in the vicinity of the isopeptide peptide to examine their behavior with deubiquitinases and ubiquitin binding domains. Our results set the ground fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37d3449f7529d561a4e1b2550e081130
https://doi.org/10.1002/anie.201306118
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7
Simple Preparation of N-Protected Chiral β-Amino Alkyl Thiols from Corresponding Iodides Employing Sodium Trithiocarbonate
Autor: Hosahalli P. Hemantha, T. M. Vishwanatha, Vommina V. Sureshbabu, Chilakapati Madhu
Publikováno v: Synthetic Communications. 43:228-235
A simple protocol for the preparation of N-protected amino alkyl thiols is reported that employs a reaction of sodium trithiocarbonate (Na2CS3) with N-protected amino alkyl iodides. Na2CS3 is easy to prepare and the protocol circumvents the use of st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13cc10f3beefdd3fd0d9171163456109
https://doi.org/10.1080/00397911.2011.595522
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8
Total chemical synthesis of polypeptides and proteins: chemistry of ligation techniques and beyond
Autor: N. Narendra, Hosahalli P. Hemantha, Vommina V. Sureshbabu
Publikováno v: Tetrahedron. 68:9491-9537
This report focuses on the concept, underlying chemistry, methods and applications of the ligation techniques that are devolved for the assembly of polypeptides and proteins. Ligation methods work on a chemoselective capture step followed by an intra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa8e24ef711362da1802c724f738f49e
https://doi.org/10.1016/j.tet.2012.08.059
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9
A simple protocol for the synthesis of triazole-linked cyclic glycopeptidomimetics: a sequential Ugi-MCR and azide–alkyne cycloaddition approach
Autor: M. Samarasimhareddy, Vommina V. Sureshbabu, Hosahalli P. Hemantha
Publikováno v: Tetrahedron Letters. 53:3104-3107
Sequential combination of Ugi-MCR and click chemistry has been employed for the synthesis of triazole linked cyclic glycopeptidomimetics. The protocol employs Poc-amino alkyl isonitriles, sugar-1-amines, azido acids, and simple aldehydes as precursor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5fb961dcb2ea1f48fe1617b5b9dc63d
https://doi.org/10.1016/j.tetlet.2012.04.034
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10
Epimerization Free Synthesis of O-Acyl Isodipeptides Employing COMU
Autor: M. Samarasimhareddy, Kuppanna Ananda, Vommina V. Sureshbabu, Hosahalli P. Hemantha
Publikováno v: Protein & Peptide Letters. 19:406-410
O-Acyl isodipeptides are prepared by coupling Boc-Ser/Thr-OBzl with Fmoc-Xaa-OH employing COMU, well known third generation peptide coupling agent. The reaction proceeds with high yield and the chemical homogeneity of the synthesized molecules were e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba7585839589a53344c4dd9975e52d5
https://doi.org/10.2174/092986612799789413
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