Výsledky vyhledávání - "Horstmann JC"

A Custom-Made Device for Reproducibly Depositing Pre-metered Doses of Nebulized Drugs on Pulmonary Cells in vitro

Autor: Justus C. Horstmann, Chelsea R. Thorn, Patrick Carius, Florian Graef, Xabier Murgia, Cristiane de Souza Carvalho-Wodarz, Claus-Michael Lehr

Publikováno v: Frontiers in bioengineering and biotechnology
Switzerland
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)

The deposition of pre-metered doses (i.e., defined before and not after exposition) at the air–liquid interface of viable pulmonary epithelial cells remains an important but challenging task for developing aerosol medicines. While some devices allo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ba7964820926885c4b826ae7741d85
https://doi.org/10.3389/fbioe.2021.643491

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Akademický článek

Transferring Microclusters of P. aeruginosa Biofilms to the Air-Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin.

Autor: Horstmann JC; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany.; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany., Laric A; Center for Molecular Signaling, Saarland University, Kirrbergerstr./Geb. 46, 66421 Homburg, Germany., Boese A; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany., Yildiz D; Center for Molecular Signaling, Saarland University, Kirrbergerstr./Geb. 46, 66421 Homburg, Germany., Röhrig T; Department of Drug Design and Optimization (DDOP), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany., Empting M; Department of Drug Design and Optimization (DDOP), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany., Frank N; Department of Microbial Natural Products (MINS), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany., Krug D; Department of Microbial Natural Products (MINS), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany., Müller R; Department of Microbial Natural Products (MINS), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany., Schneider-Daum N; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany., de Souza Carvalho-Wodarz C; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany., Lehr CM; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany.; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2022 Jan 14; Vol. 8 (1), pp. 137-149. Date of Electronic Publication: 2021 Dec 17.

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Akademický článek

Tobramycin Liquid Crystal Nanoparticles Eradicate Cystic Fibrosis-Related Pseudomonas aeruginosa Biofilms.

Autor: Thorn CR; Clinical and Health Science, University of South Australia, North Tce, Adelaide, SA, 5000, Australia.; The Basil Hetzel Institute for Translational Health Research, Woodville, SA, 5011, Australia.; ARC Centre for Excellence in Bio-Nano Science and Technology, Australia.; Adelaide Biofilm Test Facility, Cancer Research Institute, University of South Australia, North Tce, Adelaide, SA, 5000, Australia., Carvalho-Wodarz CS; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123, Saarbrücken, Germany., Horstmann JC; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, 66123, Saarbrücken, Germany., Lehr CM; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, 66123, Saarbrücken, Germany., Prestidge CA; Clinical and Health Science, University of South Australia, North Tce, Adelaide, SA, 5000, Australia.; ARC Centre for Excellence in Bio-Nano Science and Technology, Australia., Thomas N; Clinical and Health Science, University of South Australia, North Tce, Adelaide, SA, 5000, Australia.; The Basil Hetzel Institute for Translational Health Research, Woodville, SA, 5011, Australia.; ARC Centre for Excellence in Bio-Nano Science and Technology, Australia.; Adelaide Biofilm Test Facility, Cancer Research Institute, University of South Australia, North Tce, Adelaide, SA, 5000, Australia.

Publikováno v: Small (Weinheim an der Bergstrasse, Germany) [Small] 2021 Jun; Vol. 17 (24), pp. e2100531. Date of Electronic Publication: 2021 May 12.

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Akademický článek

A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms.

Autor: Schütz C; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Saarbrücken, 66123, Germany.; Department of Pharmacy, Saarland University, Campus E8.1, Saarbrücken, 66123, Germany., Ho DK; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; Department of Pharmacy, Saarland University, Campus E8.1, Saarbrücken, 66123, Germany.; Department of Bioengineering, School of Medicine, University of Washington, Seattle, WA, 98195, USA., Hamed MM; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Saarbrücken, 66123, Germany., Abdelsamie AS; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Saarbrücken, 66123, Germany.; Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki, Cairo, 12622, Egypt., Röhrig T; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Saarbrücken, 66123, Germany., Herr C; Department of Internal Medicine V - Pulmonology, Allergology and Critical Care Medicine, Saarland University, Building 41, Homburg, 66421, Germany., Kany AM; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Saarbrücken, 66123, Germany., Rox K; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Saarbrücken, 66123, Germany.; Department of Chemical Biology (CBIO), Helmholtz Centre for Infection Research (HZI), Inhoffenstr. 7, Braunschweig, 38124, Germany., Schmelz S; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Saarbrücken, 66123, Germany.; Department of Structure and Function of Proteins (SFPR), Helmholtz Centre for Infection Research (HZI), Inhoffenstr. 7, Braunschweig, 38124, Germany., Siebenbürger L; PharmBioTec GmbH, Science Park 1, Saarbrücken, 66123, Germany., Wirth M; PharmBioTec GmbH, Science Park 1, Saarbrücken, 66123, Germany., Börger C; PharmBioTec GmbH, Science Park 1, Saarbrücken, 66123, Germany., Yahiaoui S; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Saarbrücken, 66123, Germany., Bals R; Department of Internal Medicine V - Pulmonology, Allergology and Critical Care Medicine, Saarland University, Building 41, Homburg, 66421, Germany., Scrima A; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Saarbrücken, 66123, Germany.; Department of Structure and Function of Proteins (SFPR), Helmholtz Centre for Infection Research (HZI), Inhoffenstr. 7, Braunschweig, 38124, Germany., Blankenfeldt W; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Saarbrücken, 66123, Germany.; Department of Structure and Function of Proteins (SFPR), Helmholtz Centre for Infection Research (HZI), Inhoffenstr. 7, Braunschweig, 38124, Germany., Horstmann JC; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; Department of Pharmacy, Saarland University, Campus E8.1, Saarbrücken, 66123, Germany., Christmann R; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; Department of Pharmacy, Saarland University, Campus E8.1, Saarbrücken, 66123, Germany., Murgia X; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; Gaiker Technology Centre, Zamudio, Bizkaia, 48170, Spain., Koch M; Leibniz Institute for New Materials, Campus D2.2, Saarbrücken, 66123, Germany., Berwanger A; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; Department of Pharmacy, Saarland University, Campus E8.1, Saarbrücken, 66123, Germany., Loretz B; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany., Hirsch AKH; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Saarbrücken, 66123, Germany.; Department of Pharmacy, Saarland University, Campus E8.1, Saarbrücken, 66123, Germany., Hartmann RW; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Saarbrücken, 66123, Germany.; Department of Pharmacy, Saarland University, Campus E8.1, Saarbrücken, 66123, Germany., Lehr CM; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; Department of Pharmacy, Saarland University, Campus E8.1, Saarbrücken, 66123, Germany., Empting M; Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus E8.1, Saarbrücken, 66123, Germany.; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Saarbrücken, 66123, Germany.; Department of Pharmacy, Saarland University, Campus E8.1, Saarbrücken, 66123, Germany.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2021 Jun; Vol. 8 (12), pp. e2004369. Date of Electronic Publication: 2021 Mar 18.

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Akademický článek

A pulmonary mucus surrogate for investigating antibiotic permeation and activity against Pseudomonas aeruginosa biofilms.

Autor: Frisch S; Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany., Boese A; Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany., Huck B; Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany., Horstmann JC; Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany., Ho DK; Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany., Schwarzkopf K; Department of Anaesthesia and Intensive Care, Klinikum Saarbrücken, Germany., Murgia X; Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany., Loretz B; Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany., de Souza Carvalho-Wodarz C; Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany., Lehr CM; Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2021 May 12; Vol. 76 (6), pp. 1472-1479.

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Akademický článek

A Custom-Made Device for Reproducibly Depositing Pre-metered Doses of Nebulized Drugs on Pulmonary Cells in vitro .

Autor: Horstmann JC; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany., Thorn CR; Clinical and Health Science, University of South Australia, Adelaide, SA, Australia., Carius P; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany., Graef F; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrücken, Germany., Murgia X; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrücken, Germany., de Souza Carvalho-Wodarz C; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrücken, Germany., Lehr CM; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany.

Publikováno v: Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2021 Apr 21; Vol. 9, pp. 643491. Date of Electronic Publication: 2021 Apr 21 (Print Publication: 2021).

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Akademický článek

Disease Models: Lung Models for Testing Drugs Against Inflammation and Infection.

Autor: Carius P; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany., Horstmann JC; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany., de Souza Carvalho-Wodarz C; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University, Saarbrücken, Germany.; Department of Pharmacy, Saarland University, Saarbrücken, Germany., Lehr CM; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarland University, Saarbrücken, Germany. claus-michael.lehr@helmholtz-hips.de.; Department of Pharmacy, Saarland University, Saarbrücken, Germany. claus-michael.lehr@helmholtz-hips.de.

Publikováno v: Handbook of experimental pharmacology [Handb Exp Pharmacol] 2021; Vol. 265, pp. 157-186.

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Akademický článek

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives.

Autor: Montefusco-Pereira CV; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS); Department of Pharmacy, Saarland University., Horstmann JC; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS); Department of Pharmacy, Saarland University., Ebensen T; Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research., Beisswenger C; Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital., Bals R; Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital., Guzmán CA; Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research., Schneider-Daum N; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)., Carvalho-Wodarz CS; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS); cristiane.carvalho@helmholtz-hips.de., Lehr CM; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS); Department of Pharmacy, Saarland University; Claus-Michael.Lehr@helmholtz-hips.de.

Publikováno v: Journal of visualized experiments : JoVE [J Vis Exp] 2020 Jun 15 (160). Date of Electronic Publication: 2020 Jun 15.

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