Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Horst-Werner Stürzbecher"'
Autor:
Maria Louka, Effrossyni Boutou, Vasiliki Bakou, Vassiliki Pappa, Anastasios Georgoulis, Horst-Werner Stürzbecher, Contantinos E. Vorgias, Dimitrios Vlachodimitropoulos
Publikováno v:
Advances in DNA Repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770e19e99d1334b9782ac55cd117f889
https://doi.org/10.5772/61355
https://doi.org/10.5772/61355
Publikováno v:
Toxicology. 193:91-109
We provide an overview of the functional interrelationship between genes and proteins related to DNA repair by homologous recombination and cell cycle regulation in relation to the progression and therapy resistance of human tumours. To ensure the hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ea7058336c1d94f406989e79a11dd7
https://doi.org/10.1016/s0300-483x(03)00291-9
https://doi.org/10.1016/s0300-483x(03)00291-9
Autor:
Eberhard Schwinger, Kirsten Jost, Sven Opitz, Horst‐Werner Stürzbecher, Alfred Ch. Feller, Stefan Krüger, Willem Hamdorf, Heiko Maacke, Klaus Diedrich, Antje Lopens, Wilhelm Henning
Publikováno v:
International Journal of Cancer. 88:907-913
Breast cancer is a major cause of cancer-related death in women. BRCA1 tumour-suppressor function is abolished in sporadic breast cancer by down-regulation of the protein level. This down-regulation inversely correlates with tumour grading. BRCA1 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca6e4fc2e779a198c535d29b507ed8a
https://doi.org/10.1002/1097-0215(20001215)88:6<907::aid-ijc11>3.0.co
https://doi.org/10.1002/1097-0215(20001215)88:6<907::aid-ijc11>3.0.co
Autor:
Peter Wagner, Horst Werner Stürzbecher, Curtis C. Harris, Sabine Buchhop, Michael K. Gibson, Xin Wei Wang
Publikováno v:
Nucleic Acids Research. 25:3868-3874
p53 is thought to function in the maintenance of genomic stability by modulating transcription and interacting with cellular proteins to influence the cell cycle, DNA repair and apoptosis. p53 mutations occur in >50% of human cancers, and cells which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ac7aa3d7b25670ca51cef5b6379fde
https://doi.org/10.1093/nar/25.19.3868
https://doi.org/10.1093/nar/25.19.3868
Publikováno v:
The EMBO Journal. 15:1992-2002
The tumour suppressor p53 prevents tumour formation after DNA damage by halting cell cycle progression to allow DNA repair or by inducing apoptotic cell death. Loss of wild-type p53 function renders cells resistant to DNA damage-induced cell cycle ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94943c02175fcf1c0f7981d244b3fdf
https://doi.org/10.1002/j.1460-2075.1996.tb00550.x
https://doi.org/10.1002/j.1460-2075.1996.tb00550.x
Autor:
Wim Vermeulen, Jan H.J. Hoeijmakers, Kathleen Forrester, Heidi Yeh, Xin Wei Wang, Michael K. Gibson, Curtis C. Harris, Horst-Werner Stürzbecher
The p53 tumor suppressor gene product is a transcriptional transactivator and a potent apoptotic inducer. The fact that many of the DNA tumor virus oncoproteins bind to p53 and affect these p53 functions indicates that this interaction is an importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b00be0c68048402799eb3fc1864ae6d7
https://doi.org/10.1385/1-59259-079-9:57
https://doi.org/10.1385/1-59259-079-9:57
Autor:
Steven P, Linke, Sagar, Sengupta, Nissim, Khabie, Beth A, Jeffries, Sabine, Buchhop, Stefan, Miska, Wilhelm, Henning, Remy, Pedeux, Xin W, Wang, Lorne J, Hofseth, Qin, Yang, Susan H, Garfield, Horst-Werner, Stürzbecher, Curtis C, Harris
Publikováno v:
Cancer research. 63(10)
p53 inhibits tumorigenesis through a variety of functions, including mediation of cell cycle arrest, premature senescence, and apoptosis.p53 also can associate with several DNA helicases and proteins involved in homologous recombination. In this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84664238503a4912ed95ca9f3d56be5d
https://pubmed.ncbi.nlm.nih.gov/12750285
https://pubmed.ncbi.nlm.nih.gov/12750285
Publikováno v:
Hybridoma. 15(3)
Monoclonal antibodies were produced against recombinant human RAD51 recombination protein. The antibodies of IgG subclasses were isolated from serum-free cell culture medium and purified by affinity chromatography on protein A-Sepharose. The antibodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bedfc2a2ea6eb9d2202fd085b8ee1c0e
https://pubmed.ncbi.nlm.nih.gov/8823618
https://pubmed.ncbi.nlm.nih.gov/8823618
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 121:A35-A35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2e1d826bfb3e759a462b8d7a75bace9
https://doi.org/10.1007/bf02572103
https://doi.org/10.1007/bf02572103