Výsledky vyhledávání - "Horst-Jürgen Heuer"

Effect of Ketoconazole on the Pharmacokinetics of the Dipeptidyl Peptidase-4 Inhibitor Teneligliptin: An Open-Label Study in Healthy White Subjects in Germany

Autor: Atsuhiro Kawaguchi, Martin Davies, Yoshinobu Nakamaru, Shuji Kinoshita, Kei Akimoto, Hiroshi Yamazaki, Horst Jürgen Heuer, Yoshiharu Hayashi, Mana Sekine, Jeff Thompson

Publikováno v: Clinical Therapeutics. 36:760-769

Objective The aim of this study was to examine the effect of ketoconazole, a potent cytochrome P450 (CYP) 3A4 and P-glycoprotein (P-gp) inhibitor, on teneligliptin pharmacokinetics and to evaluate the safety of combined administration of teneliglipti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7261d5ab657be5962357e4fc24037c
https://doi.org/10.1016/j.clinthera.2014.03.002

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Investigation of Potential Pharmacokinetic Interactions Between Teneligliptin and Metformin in Steady-state Conditions in Healthy Adults

Autor: Noriko Hisanaga, Kei Akimoto, Yoshiharu Hayashi, Horst Jürgen Heuer, Martin Davies, Yoshinobu Nakamaru

Publikováno v: Clinical therapeutics. 37(9)

Purpose We assessed the effects of coadministration of metformin and teneligliptin on their pharmacokinetics in steady-state conditions relative to the administration of either drug alone. Methods This was a Phase I, single-center, open-label, 2-way

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f1585b5189976b9ddd9d47e39b2824
https://pubmed.ncbi.nlm.nih.gov/26212570

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Single and Multiple Dose Pharmacokinetics of a Sustained-Release Formulation of Bunazosin (E1015) in Healthy Young and Elderly Volunteers

Autor: Werner Weber, Nobumichi Morishita, Paul Branagan, Günther Pabst, A. C. Houston, Jiro Hasegawap, Yoshiro Tomono, Horst-Jürgen Heuer

Publikováno v: Drug Investigation. 6:62-69

The results of 1 multiple dose and 2 single dose pharmacokinetic studies of sustained-release bunazosin (Bunazosin Retard®) 6mg in healthy elderly (n = 47) and healthy young (n = 12) volunteers are suggestive of an age-related difference in the drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::250f39751c452cd984a2bccdad620f5f
https://doi.org/10.1007/bf03258454

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Single Dose Crossover Study to Evaluate the Absolute Bioavailability of a Sustained-Release Formulation of Bunazosin (E1015) in Healthy Male Volunteers

Autor: Jiro Hasegawa, Horst-Jürgen Heuer, Nobumichi Morishita, Yoshiro Tomono

Publikováno v: Drug Investigation. 6:5-9

An open-label randomised crossover study was undertaken to investigate the pharmacokinetics of intravenous bunazosin, and to determine the absolute bioavailabilities of the standard and sustained-release tablet formulations of the drug. 12 healthy vo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4133d4e5707d229ada0930aa41c3f933
https://doi.org/10.1007/bf03259419

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Experience with recruitment of special patient populations collected during an open, parallel group, drug-drug interaction trial to evaluate pharmacokinetics of a new dopamine agonist and levodopa/carbidopa in patients with idiopathic restless legs syndrome

Autor: Werner Feuerer, Horst Jürgen Heuer, Manuela Koch, Tamara Richter

Publikováno v: BMC News and views. 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d9b3d0b211a17d314e66974e4d5eb24
https://doi.org/10.1186/2048-4623-4-s1-p0004

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