Zobrazeno 1 - 10
of 661
pro vyhledávání: '"Horst Vogel"'
Autor:
Zhongjie Ye, Nicola Galvanetto, Leonardo Puppulin, Simone Pifferi, Holger Flechsig, Melanie Arndt, Cesar Adolfo Sánchez Triviño, Michael Di Palma, Shifeng Guo, Horst Vogel, Anna Menini, Clemens M. Franz, Vincent Torre, Arin Marchesi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which functions as an ion channel and a phospholipid scramblase. Despite the availability of several TMEM16F cryogenic electron microscopy (cryo-EM) structures, the mechanism
Externí odkaz:
https://doaj.org/article/9bd25adc2ffd46f18c51a341f17f0ddc
Autor:
Tao Ma, Lei Wang, Anping Chai, Chao Liu, Wenqiang Cui, Shuguang Yuan, Shannon Wing Ngor Au, Liang Sun, Xiaokang Zhang, Zhenzhen Zhang, Jianping Lu, Yuanzhu Gao, Peiyi Wang, Zhifang Li, Yujie Liang, Horst Vogel, Yu Tian Wang, Daping Wang, Kaige Yan, Huawei Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract ClC-2 transports chloride ions across plasma membranes and plays critical roles in cellular homeostasis. Its dysfunction is involved in diseases including leukodystrophy and primary aldosteronism. AK-42 was recently reported as a specific in
Externí odkaz:
https://doaj.org/article/1b44828fd4bb481d8c3c6800caa356fb
Autor:
Kong-Fu Zhu, Chuang Yuan, Yong-Ming Du, Kai-Lei Sun, Xiao-Kang Zhang, Horst Vogel, Xu-Dong Jia, Yuan-Zhu Gao, Qin-Fen Zhang, Da-Ping Wang, Hua-Wei Zhang
Publikováno v:
Military Medical Research, Vol 10, Iss 1, Pp 1-14 (2023)
Abstract Drug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it is usually time- and effort-consuming. Structural biology has been demonstrated as a powerfu
Externí odkaz:
https://doaj.org/article/1e7aa7320fc1484296f985399f26e046
Autor:
Hang Zhang, Shiyu Wang, Zhenzhen Zhang, Mengzhuo Hou, Chunyu Du, Zhenye Zhao, Horst Vogel, Zhifang Li, Kaige Yan, Xiaokang Zhang, Jianping Lu, Yujie Liang, Shuguang Yuan, Daping Wang, Huawei Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Pannexin 2 plays critical roles in many physiological processes but its mechanism remain unclear. Here, authors report the cryo-EM structure of human Panx2 in the open state and identify critical residues for its gating.
Externí odkaz:
https://doaj.org/article/e685f0fe2d0f41819ac477f73f7bc676
Autor:
Yingyi Zhang, Patricia M. Dijkman, Rongfeng Zou, Martina Zandl-Lang, Ricardo M. Sanchez, Luise Eckhardt-Strelau, Harald Köfeler, Horst Vogel, Shuguang Yuan, Mikhail Kudryashev
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Pentameric ligand-gated ion channels (pLGICs) are key players in neurotransmission and have been shown to be modulated by the lipid environment, however the underlying mechanism is not well understood. Here, the authors report structures of the pLGIC
Externí odkaz:
https://doaj.org/article/c3dc1144479e42dfbcbc8d743307e558
Autor:
Lotta Tegler, Karolina Corin, Horst Pick, Jennifer Brookes, Michael Skuhersky, Horst Vogel, Shuguang Zhang
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract G protein-coupled receptors (GPCRs) are vital for diverse biological functions, including vision, smell, and aging. They are involved in a wide range of diseases, and are among the most important targets of medicinal drugs. Tools that facili
Externí odkaz:
https://doaj.org/article/d25ff2f655d440be8967bb59115106d6
Autor:
H. C. Stephen Chan, Yueming Xu, Liang Tan, Horst Vogel, Jianjun Cheng, Dong Wu, Shuguang Yuan
Publikováno v:
ACS Central Science, Vol 6, Iss 2, Pp 274-282 (2020)
Externí odkaz:
https://doaj.org/article/bde47fbe587a4a428ff5afaf4a97398e
Publikováno v:
RSC Advances. 13:4422-4430
The sandwich structure in human melatonin receptors was disrupted. In MT1 this opened a gate for the water molecule from the bulk environment to fluctuate into the inner space. In MT2, the sandwich structure was stabilized by MEL during the whole MD
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151031 (2016)
Natural Killer (NK) cells mediate innate immunity to infected and transformed cells. Yet, NK cells can also mount hapten-specific recall responses thereby contributing to contact hypersensitivity (CHS). However, since NK cells lack antigen receptors
Externí odkaz:
https://doaj.org/article/f3ea2f6d993541c6a70b24bde2a92344
Autor:
Horst Vogel, H. C. Stephen Chan, Jianjun Cheng, Dong Wu, Yueming Xu, Shuguang Yuan, Liang Tan
Publikováno v:
ACS Central Science, Vol 6, Iss 2, Pp 274-282 (2020)
ACS Central Science
ACS Central Science
G protein-coupled receptors play essential roles in cellular processes such as neuronal signaling, vision, olfaction, tasting, and metabolism. As GPCRs are the most important drug targets, understanding their interactions with ligands is of utmost im