Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Horst Thiermann"'
Autor:
Virginia Egea, Karina Lutterberg, Dirk Steinritz, Simone Rothmiller, Konrad Steinestel, Jan Caca, Andreas Nerlich, Helmut Blum, Sarah Reschke, Sajjad Khani, Alexander Bartelt, Franz Worek, Horst Thiermann, Christian Weber, Christian Ries
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-12 (2024)
Abstract Sulfur mustard (SM) is a highly toxic chemical warfare agent. Exposure to SM results in various pathologies including skin lesions with subsequent impaired wound healing. To date, there are no effective treatments available. Here we discover
Externí odkaz:
https://doaj.org/article/06210cd3488c496e91580c92cd6a7e1e
Autor:
Harald John, Horst Thiermann
Publikováno v:
Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 19, Iss , Pp 20-31 (2021)
Intoxication by organophosphorus (OP) poisons, like nerve agents and pesticides, is characterized by the life-threatening inhibition of acetylcholinesterase (AChE) caused by covalent reaction with the serine residue of the active site of the enzyme (
Externí odkaz:
https://doaj.org/article/7a23f30471754693ae0a18142d72bb33
Publikováno v:
Stem Cells International, Vol 2022 (2022)
Motor neurons (MNs) derived from human-induced pluripotent stem cells (hiPSC) hold great potential for the treatment of various motor neurodegenerative diseases as transplantations with a low-risk of rejection are made possible. There are many hiPSC
Externí odkaz:
https://doaj.org/article/cfaf7c1a59ee443b93f56272c5afdb00
In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase
Publikováno v:
Molecules, Vol 25, Iss 13, p 3029 (2020)
The implementation of the Chemical Weapons Convention (CWC) in 1997 was a milestone in the prohibition of chemical warfare agents (CWA). Yet, the repeated use of CWA underlines the ongoing threat to the population. Organophosphorus (OP) nerve agents
Externí odkaz:
https://doaj.org/article/49d1fb336f0a4857ace042c3615a4842
Autor:
Robin Lüling, Harald John, Thomas Gudermann, Horst Thiermann, Harald Mückter, Tanja Popp, Dirk Steinritz
Publikováno v:
Cells, Vol 7, Iss 9, p 126 (2018)
The chemosensory transient receptor potential ankyrin 1 (TRPA1) ion channel perceives different sensory stimuli. It also interacts with reactive exogenous compounds including the chemical warfare agent sulfur mustard (SM). Activation of TRPA1 by SM r
Externí odkaz:
https://doaj.org/article/02801ca38ba74d61bfb6a5832bf2228a
Publikováno v:
Toxicology Letters. 382:41-46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2edf6c5fea9825917138ac172edf79c0
https://doi.org/10.1016/j.toxlet.2023.05.010
https://doi.org/10.1016/j.toxlet.2023.05.010
Autor:
Katharina Müller-Dott, Sarah Christine Raßmuß, Marc-Michael Blum, Horst Thiermann, Harald John, Dirk Steinritz
Publikováno v:
Toxicology Letters. 376:51-59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1db751f0e27a334c0b1e67d0400262e0
https://doi.org/10.1016/j.toxlet.2023.01.007
https://doi.org/10.1016/j.toxlet.2023.01.007
Publikováno v:
Archives of Toxicology. 97:429-439
Transient receptor potential (TRP) channels are important in the sensing of pain and other stimuli. They may be triggered by electrophilic agonists after covalent modification of certain cysteine residues. Sulfur mustard (SM) is a banned chemical war
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2074fae210070236622e918c00a849
https://doi.org/10.1007/s00204-022-03411-1
https://doi.org/10.1007/s00204-022-03411-1
Autor:
Gabriele Horn, Catherine Schäfers, Horst Thiermann, Sandra Völkl, Annette Schmidt, Simone Rothmiller
Publikováno v:
Archives of Toxicology. 96:3053-3066
Chronic wounds, skin blisters, and ulcers are the result of skin exposure to the alkylating agent sulfur mustard (SM). One potential pathomechanism is senescence, which causes permanent growth arrest with a pro-inflammatory environment and may be ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07792256288c40eb5e02d9848b2ee73e
https://doi.org/10.1007/s00204-022-03346-7
https://doi.org/10.1007/s00204-022-03346-7
Publikováno v:
Drug Testing and Analysis. 14:1140-1148
Sulfur mustard (SM, bis[2-chloroethyl]-sulfide) is a banned chemical warfare agent deployed in the violent conflict in the Middle East poisoning humans and animals. For legal reasons, bioanalytical methods are mandatory proving exposure to SM. Reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e72485214215f2e23c1b7c3392533a9
https://doi.org/10.1002/dta.3236
https://doi.org/10.1002/dta.3236