Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Horst Irlbacher"'
Autor:
Rienk Offringa, Ralf Lesche, Iris Oezen, Michael Platten, Daniel Baumann, Christiane A Opitz, Ahmed Sadik, Catherine Olesch, Frederik Cichon, Norbert Schmees, Ulrike Roehn, Florian Prinz, Detlef Stoeckigt, Katharina Sahm, Nirmeen Elmadany, Christina Kober, Julian Roewe, Lars Roese, Benjamin Bader, Mátyás Gorjánácz, Helge Gottfried Roider, Gabriele Leder, Horst Irlbacher, Julien Lefranc, Mine Oezcan-Wahlbrink, Ankita Sati Batra, Rafael Carretero, Hilmar Weinmann, Ingo V Hartung, Bertolt Kreft, Ilona Gutcher
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background The metabolism of tryptophan to kynurenines (KYN) by indoleamine-2,3-dioxygenase or tryptophan-2,3-dioxygenase is a key pathway of constitutive and adaptive tumor immune resistance. The immunosuppressive effects of KYN in the tumor microen
Externí odkaz:
https://doaj.org/article/bc1e59d7b2b148a6869f255df5b9d454
Autor:
Thomas M. Zollner, Antonius Ter Laak, Daryl S. Walter, Jens Nagel, Anne-Marie Coelho, Horst Irlbacher, Michaele Peters, Andrea Rotgeri, Marcus Koppitz, Andreas Steinmeyer, Nico Bräuer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2700-2705
Here we report on novel and potent pyridyl-cycloalkyl-carboxylic acid inhibitors of microsomal prostaglandin E synthase-1 (PTGES). PTGES produces, as part of the prostaglandin pathway, prostaglandin E2 which is a well-known driver for pain and inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96084e274cca1ae051e390fee4a558ac
https://doi.org/10.1016/j.bmcl.2019.07.007
https://doi.org/10.1016/j.bmcl.2019.07.007
Autor:
Antje Margret Wengner, Hans Briem, Stefan Gradl, Srinivasan Rengachari, Tobias Heinrich, Carl Friedrich Nising, Detlef Stöckigt, Franz von Nussbaum, Ulf Bömer, Julien Lefranc, Benjamin Bader, Anne Mengel, Dominik Mumberg, Roman C. Hillig, Volker K Schulze, Florian Prinz, Daniel Panne, József Bálint, Horst Irlbacher
Publikováno v:
Journal of medicinal chemistry. 63(2)
The serine/threonine kinase TBK1 (TANK-binding kinase 1) and its homologue IKKe are noncanonical members of the inhibitor of the nuclear factor κB (IκB) kinase family. These kinases play important roles in multiple cellular pathways and, in particu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2adefea1933f340f0c4c4d7bbf5be386
https://pubmed.ncbi.nlm.nih.gov/31859507
https://pubmed.ncbi.nlm.nih.gov/31859507
Autor:
Jenny Viklund, Martin Andersson, Ashley Eheim, Johan Lindström, Maria Quanz, Ulrika Ericsson, Ellermann Manuel, Andrea Glasauer, Benjamin Bader, Judith Guenther, Jörg Weiske, Katrin Nowak-Reppel, Nina Queisser, Camilla Silvander, Stefanie Bunse, Anja Giese, Tobias Ginman, Rickard Forsblom, Horst Irlbacher, Lionel Trésaugues, Hanna Meyer, Marcus Bauser, Andrea Haegebarth, Roland Neuhaus, Mátyás Gorjánácz, F. Rahm
Publikováno v:
'ACS Chemical Biology ', vol: 12, pages: 1986-1992 (2017)
MTH1 is a hydrolase responsible for sanitization of oxidized purine nucleoside triphosphates to prevent their incorporation into replicating DNA. Early tool compounds published in the literature inhibited the enzymatic activity of MTH1 and subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6b2c6ca127fb71bb1dadea18236e7f
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:47719
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:47719
Autor:
Benjamin Bader, Ilona Gutcher, Ludiwg Zorn, Lars Roese, Hilmar Weinmann, Christina Kober, Michael Platten, Ulrike Roehn, Bertolt Kreft, Iris Oezen, Horst Irlbacher, Detlef Stoeckigt, Rafael Carretero, Norbert Schmees, Ingo Hartung
Publikováno v:
Cancer Research. 79:4454-4454
Re-constitution of anti-tumor T-cell responses by clinically-approved immune checkpoint inhibitors (ICIs) targeting CTLA4 or PD-1/PD-L1 represents a breakthrough cancer therapy. Nevertheless, a substantial number of patients do not benefit from these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b5018e1ced8aa35387f8677f5fb5b87
https://doi.org/10.1158/1538-7445.am2019-4454
https://doi.org/10.1158/1538-7445.am2019-4454
Autor:
Julian Roewe, Horst Irlbacher, Florian Prinz, Mátyás Gorjánácz, Lars Roese, Ulrike Roehn, Bertolt Kreft, Norbert Schmees, Katharina Sahm, Michael Platten, Benjamin Bader, Hilmar Weinmann, Christina Kober, Rafael Carretero, Ingo Hartung, Iris Oezen, Ilona Gutcher, Detlef Stoeckigt
Publikováno v:
Cancer Research. 79:1288-1288
Tumor cells co-opt multiple pathways in order to evade attack by infiltrating immune cells. One such mechanism is the upregulation of indole-2,3-dioxygenase (IDO1) and/or tryptophan-2,3-dioxygenase (TDO2), both of which are first-step, rate-limiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eb4fa5d5c5885eaf1f788ce23b46a4b
https://doi.org/10.1158/1538-7445.am2019-1288
https://doi.org/10.1158/1538-7445.am2019-1288
Publikováno v:
Genes & Development. 19:1811-1822
The division of eukaryotic chromatin into functionally distinct domains is critical to implement gene expression programs that drive the development of multicellular organisms. Regions termed euchromatin exist in the genome that are generally conduci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d546c691c9e948ff41a7dbc91d3c43e
https://doi.org/10.1101/gad.334805
https://doi.org/10.1101/gad.334805
Autor:
Anja Fromm, Michael Fromm, Steffen Borden, Horst Irlbacher, Frederic Jaisser, Tim Ziera, Susanne M. Krug, Celine Latouche
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(11)
Aldosterone is the principal hormonal regulator of sodium homeostasis in vertebrates. It exerts its actions through the mineralocorticoid receptor (MR) that regulates the transcription of specific target genes. In recent years, a number of MR target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b853a57af831a258358eb7fe64f8d50c
https://pubmed.ncbi.nlm.nih.gov/19567370
https://pubmed.ncbi.nlm.nih.gov/19567370
Publikováno v:
BMC Molecular Biology
BMC Molecular Biology, Vol 9, Iss 1, p 100 (2008)
BMC Molecular Biology, Vol 9, Iss 1, p 100 (2008)
Background Replication initiation at origins of replication in the yeast genome takes place on chromatin as a template, raising the question how histone modifications, for instance histone acetylation, influence origin firing. Initiation requires bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfff387afb5b8984c8049aa606028cb7
https://www.ncbi.nlm.nih.gov/pubmed/18990212
https://www.ncbi.nlm.nih.gov/pubmed/18990212
Autor:
Anja Richter, Luisella Toschi, Andrea Haegebarth, Michael Steckel, Horst Irlbacher, Andrea Glasauer
Publikováno v:
Cancer Research. 75:4460-4460
Cancer cells are characterized by an increase in the rate of reactive oxygen species (ROS) production and an altered redox environment compared to normal cells. The role of ROS in tumorigenesis is two-fold. On the one hand, ROS play a causal role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b40d6bea68f7b17816311cfeeb1bc27
https://doi.org/10.1158/1538-7445.am2015-4460
https://doi.org/10.1158/1538-7445.am2015-4460