Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Horst H. Simon"'
Autor:
Manuela Scali, Paola Sgadò, Prem Prakash Tripathi, Yuri Bozzi, Francesca Vaglini, Cristina Viaggi, Horst H. Simon, Simona Casarosa, G.U. Corsini
Publikováno v:
Neuroscience. 159:842-849
The En2 gene, coding for the homeobox-containing transcription factor Engrailed-2 (EN2), has been associated to autism spectrum disorder (ASD). Due to neuroanatomical and behavioral abnormalities, which partly resemble those observed in ASD patients,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0dcc2f192c8dc66a82204f17c8ff211
https://doi.org/10.1016/j.neuroscience.2009.01.007
https://doi.org/10.1016/j.neuroscience.2009.01.007
GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-β for its neuroprotective action
Autor:
Andreas Schober, Heike Peterziel, Klaus Unsicker, Horst H. Simon, Christopher S. von Bartheld, Kerstin Krieglstein
Publikováno v:
Neurobiology of Disease, Vol 25, Iss 2, Pp 378-391 (2007)
GDNF is a potent neurotrophic factor for nigrostriatal dopaminergic neurons in vitro and in animal models of Parkinson's disease (PD), but has largely failed when tested in therapeutic applications in human PD. We report here that GDNF requires trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1b644734f3b881796f16a238079ba6
http://www.sciencedirect.com/science/article/pii/S0969996106002567
http://www.sciencedirect.com/science/article/pii/S0969996106002567
Autor:
Sherri L. Galasso, Geert M.J. Ramakers, Daniel Gherbassi, Kambiz N. Alavian, Richard H. Dyck, Marten P. Smidt, Paola Sgadò, Lavinia Alberi, Horst H. Simon
Publikováno v:
Proceedings of the National Academy of Sciences. 103:15242-15247
The homeobox transcription factors Engrailed-1 and Engrailed-2 are required for the survival of mesencephalic dopaminergic neurons in a cell-autonomous and gene-dose-dependent manner. Because of this requirement, the cells die by apoptosis when all f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f6e6b868c700e092fcfe880e6397cd
https://doi.org/10.1073/pnas.0602116103
https://doi.org/10.1073/pnas.0602116103
Publikováno v:
Molecular and Cellular Neuroscience. 28:96-105
In vertebrates and insects, the homeobox transcription factors of the engrailed family have a dual function. They take part in regionalization during early embryogenesis and later in neuronal specification. In mammals, two engrailed homologues exist,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c075a6635ebf0fac33b9c4f26042d1
https://doi.org/10.1016/j.mcn.2004.08.016
https://doi.org/10.1016/j.mcn.2004.08.016
Autor:
Sandrine Thuret, Simone M. Smits, Kevin C K Lloyd, Kambiz N. Alavian, Richard H. Dyck, Marten P. Smidt, Martin Gassmann, Horst H. Simon, Rüdiger Klein
Publikováno v:
Journal of Neurochemistry. 91:1302-1311
Degeneration of dopaminergic neurons in the substantia nigra is associated with one of the most prominent human neurological disorders, Parkinson's disease. It is therefore of high interest to identify molecules with trophic effects on this neuronal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47c6ec6dec06b4afc9319dad9e408314
https://doi.org/10.1111/j.1471-4159.2004.02809.x
https://doi.org/10.1111/j.1471-4159.2004.02809.x
Publikováno v:
Development. 131:3229-3236
The neuropathological hallmark of Parkinson’s disease is the loss of dopaminergic neurons in the substantia nigra pars compacta, presumably mediated by apoptosis. The homeobox transcription factors engrailed 1 and engrailed 2 are expressed by this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6a44b5476b1a89bb87f492017fcc4e
https://doi.org/10.1242/dev.01128
https://doi.org/10.1242/dev.01128
Publikováno v:
Molecular and Cellular Neuroscience. 25:394-405
The hallmark of Parkinson's Disease is the degenerative loss of mesencephalic dopaminergic (mDA) neurons. Previous studies have shown that the homeobox transcription factors, engrailed-1 and -2, are essential for the survival of these cells. To ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d239592e22d5b0913a05bb22d77c4f
https://doi.org/10.1016/j.mcn.2003.11.004
https://doi.org/10.1016/j.mcn.2003.11.004
Publikováno v:
The Journal of Neuroscience. 21:3126-3134
Deficiencies in neurotransmitter-specific cell groups in the midbrain result in prominent neural disorders, including Parkinson's disease, which is caused by the loss of dopaminergic neurons of the substantia nigra. We have investigated in mice the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d997622abca32f1f024a0a04d7edb90
https://doi.org/10.1523/jneurosci.21-09-03126.2001
https://doi.org/10.1523/jneurosci.21-09-03126.2001
Publikováno v:
Nature. 378:394-398
The receptor erbB2/neu is a member of the epidermal growth factor receptor (EGFR or erbB) family that also includes erbB3 and erbB4. Amplification of the erbB2/neu gene is found in many cancer types and its overexpression is correlated with a poor pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8227e17ff40f856205d2cd76b724755d
https://doi.org/10.1038/378394a0
https://doi.org/10.1038/378394a0
Autor:
Donata Orioli, Greg Lemke, Rüdiger Klein, Martin Gassmann, Cary Lai, Franca Casagranda, Horst H. Simon
Publikováno v:
Nature. 378:390-394
Various in vitro studies have suggested that ErbB4 (HER4) is a receptor for the neuregulins, a family of closely related proteins implicated as regulators of neural and muscle development, and of the differentiation and oncogenic transformation of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75994adfde28baee51226b12b2c92374
https://doi.org/10.1038/378390a0
https://doi.org/10.1038/378390a0