Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Horst H. Klump"'
Publikováno v:
Quarterly Reviews of Biophysics. 53
When the iconic DNA genetic code is expressed in terms of energy differentials, one observes that information embedded in chemical sequences, including some biological outcomes, correlate with distinctive free energy profiles. Specifically, we find c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08f036072df4b866362ebd6135b87ca
https://doi.org/10.1017/s0033583520000098
https://doi.org/10.1017/s0033583520000098
Publikováno v:
Biopolymers. 101:1-12
Repetitive DNA sequences exhibit complex structural and energy landscapes, populated by metastable, non-canonical states, that favor expansion and deletion events correlated with disease phenotypes. To probe the origins of such genotype-phenotype lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f022742db5ee838ac41cc473368e4963
https://doi.org/10.1002/bip.22236
https://doi.org/10.1002/bip.22236
Autor:
Horst H. Klump
Publikováno v:
Moleküle aus dem All?
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08d00933e28410f2256a43c33e9e69f9
https://doi.org/10.1002/9783527653935.ch8
https://doi.org/10.1002/9783527653935.ch8
Publikováno v:
Biopolymers. 93:355-369
Clusters of closely spaced oxidative DNA lesions present challenges to the cellular repair machinery. When located in opposing strands, base excision repair (BER) of such lesions can lead to double strand DNA breaks (DSB). Activation of BER and DSB r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e43d7bd344e3f51dbdb0bf1f6ae14be0
https://doi.org/10.1002/bip.21343
https://doi.org/10.1002/bip.21343
Publikováno v:
Proceedings of the National Academy of Sciences. 105:18326-18330
Biopolymers exhibit rough energy landscapes, thereby allowing biological processes to access a broad range of kinetic and thermodynamic states. In contrast to proteins, the energy landscapes of nucleic acids have been the subject of relatively few ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1dfef91cdd9b17b3db025328c0b014
https://doi.org/10.1073/pnas.0810376105
https://doi.org/10.1073/pnas.0810376105
Publikováno v:
Biopolymers. 86:136-147
Cytosine-rich DNA at low pH adopts an antiparallel tetraplex structure via the intercalation of two partially protonated, parallel stranded duplexes. This intriguing structural motif has been named i-DNA. We have used a combination of spectroscopic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31750ed6db00e402681d0fc801837846
https://doi.org/10.1002/bip.20712
https://doi.org/10.1002/bip.20712
Publikováno v:
Nucleic Acids Research
Trinucleotide repeats are involved in a number of debilitating diseases such as myotonic dystrophy. Twelve to seventy-five base-long (CTG)n oligodeoxynucleotides were analysed using a combination of biophysical [UV-absorbance, circular dichroism and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3bcd9f3e00987f9c06bcc5862f6e574
https://doi.org/10.1093/nar/gki716
https://doi.org/10.1093/nar/gki716
Autor:
Anne V. Corrigall, Horst H. Klump, P.N. Meissner, Ralph E. Kirsch, Mbulelo H. Maneli, Lester M. Davids
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1650:10-21
The effects of various protoporphyrinogen oxidase (PPOX) mutations responsible for variegate porphyria (VP), the roles of the arginine-59 residue and the glycines in the conserved flavin binding site, in catalysis and/or cofactor binding, were examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9327c8a91a7b8dc444f21736476a0022
https://doi.org/10.1016/s1570-9639(03)00186-9
https://doi.org/10.1016/s1570-9639(03)00186-9
Publikováno v:
Journal of Molecular Biology. 310:1011-1025
The melting temperature of the poly(dA)·poly(dT) double helix is exquisitely sensitive to salt concentration, and the helix-to-coil transition is sharp. Modern calorimetric instrumentation allows this transition to be detected and characterized with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::383dbd376c0927cd9986a287ac5e4908
https://doi.org/10.1006/jmbi.2001.4841
https://doi.org/10.1006/jmbi.2001.4841
Publikováno v:
Journal of the American Chemical Society. 132:4095-4097
Energy coupling between distal DNA domains, may have profound regulatory consequences for biological processes, allowing for allosteric control of nucleic acid function. Repair of oxidative lesions at or near triplet repeat domains can enhance DNA ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f20fe3d96962dc1a06dcbfbdfdbaab5
https://doi.org/10.1021/ja1002857
https://doi.org/10.1021/ja1002857