Výsledky vyhledávání - "Horst Dürkop"

Akademický článek

CD30-Positive Extracellular Vesicles Enable the Targeting of CD30-Negative DLBCL Cells by the CD30 Antibody-Drug Conjugate Brentuximab Vedotin

Autor: Liudmila Lobastova, Marcus Lettau, Felix Babatz, Thais Dolzany de Oliveira, Phuong-Hien Nguyen, Bianca Alves Pauletti, Astrid C. Schauss, Horst Dürkop, Ottmar Janssen, Adriana F. Paes Leme, Michael Hallek, Hinrich P. Hansen

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

CD30, a member of the TNF receptor superfamily, is selectively expressed on a subset of activated lymphocytes and on malignant cells of certain lymphomas, such as classical Hodgkin Lymphoma (cHL), where it activates critical bystander cells in the tu

Externí odkaz: https://doaj.org/article/ee4ad5abc83c476f806f4f05d2d13b45

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Antibody-based delivery of tumor necrosis factor (L19-TNFα) and interleukin-2 (L19-IL2) to tumor-associated blood vessels has potent immunological and anticancer activity in the syngeneic J558L BALB/c myeloma model

Autor: Horst Dürkop, Ulf Harnack, Ulrike Erben, Dario Neri, Hans D. Menssen, Burkhard Hirsch

Publikováno v: Journal of Cancer Research and Clinical Oncology. 144:499-507

To analyze the impact of TNFα or IL2 on human lymphocytes in vitro and the anti-tumor and immune-modifying effects of L19-IL2 and L19-TNFα on subcutaneously growing J558L myeloma in immunocompetent mice. PBMCs from three healthy volunteers were inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9964b810a6d296691577d3ce8affcaa
https://doi.org/10.1007/s00432-017-2564-6

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Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861

Autor: Hendrik Fuchs, Alexander Weng, Cheenu Bhargava, Matthias F. Melzig, Horst Dürkop, Xiangli Zhao

Publikováno v: Molecular Oncology

Targeted cancer therapy provides the basis for the arrest of tumor growth in aggressive pancreatic carcinoma, however, a number of protein-based targeted toxins lack efficacy due to insufficient endosomal escape after being endocytosed. Therefore, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb72bf6ddf14f6e5c7debb271bed6cf5
http://europepmc.org/articles/PMC5664001

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A new monoclonal antibody (CAL2) detects CALRETICULIN mutations in formalin-fixed and paraffin-embedded bone marrow biopsies

Autor: Roshanak Bob, Andreas Roth, Anna Streubel, Christian Erck, Horst Dürkop, Hans-Michael Kvasnicka, Harald Stein, Henrik Martens, Dietrich Kämpfe

Publikováno v: Leukemia

Recent advances in the diagnostic of myeloproliferative neoplasms (MPNs) discovered CALRETICULIN (CALR) mutations as a major driver in these disorders. In contrast to JAK2 mutations being mainly associated with polycythaemia vera, CALR mutations are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cca6d4ec765f1c7452023a5408cb4c1
http://europepmc.org/articles/PMC4705422

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Dianthin-EGF is an effective tumor targeted toxin in combination with saponins in a xenograft model for colon carcinoma

Autor: Roger Gilabert-Oriol, Alexander Weng, Mayank Thakur, Matthias F. Melzig, Nicola Beindorff, Mathias Lukas, Hendrik Fuchs, Horst Dürkop, Winfried Brenner, Benedicta von Mallinckrodt

Publikováno v: Future Oncology. 10:2161-2175

ABSTRACT Aims: The intention of this work was to lift saponin supported tumor targeted therapies onto the next level by using targeted toxins in nude mice xenotransplant models. Materials & methods: Combined application of dianthin coupled to EGF and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2514fc4e666d370e5cd5103f1f05ed0f
https://doi.org/10.2217/fon.14.164

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Abundant in vitro expression of the oncofetal ED-B-containing fibronectin translates into selective pharmacodelivery of 131I-L19SIP in a prostate cancer patient

Autor: Leonardo Giovannoni, Horst Dürkop, Ricarda Locher, Paola Anna Erba, Emilio Bombardieri, Hans D. Menssen, Burkhard Hirsch, Dario Neri

Publikováno v: Journal of Cancer Research and Clinical Oncology. 140:35-43

The extradomain B of fibronectin (ED-B) is a promising vascular target for selective pharmacodelivery in cancer patients. We analyzed a large series of prostatectomies from patients with prostate cancer, hyperplastic prostate disease, and normal pros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbae95458e3f529e00ee60266088312a
https://doi.org/10.1007/s00432-013-1538-6

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A novel A20 (TNFAIP3) antibody (Ber-A20) can be used to detect unmutated A20 by immunohistology

Autor: Horst Dürkop, Lothar Lucka, Burkhard Hirsch, Ming-Qing Du, Florian Wagner, Maria Grünbaum, Yingwen Bi, Harald Stein

Publikováno v: Histopathology. 60:E19-E27

Hirsch B, Grunbaum M, Wagner F, Bi Y, Lucka L, Du M-Q, Stein H & Durkop H (2012) Histopathology 60, E19–E27 A novel A20 (TNFAIP3) antibody (Ber-A20) can be used to detect unmutated A20 by immunohistology Aims: A20 (TNFAIP3) is a nuclear factor-κB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb06b0a562222df23a977b4be6b1450f
https://doi.org/10.1111/j.1365-2559.2012.04181.x

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Kutanes anaplastisches großzelliges Lymphom

Autor: Wolfram Sterry, Jürgen Eberle, Frank K. Braun, M.E. Kadin, Chalid Assaf, Nadya Al-Yacoub, Horst Dürkop, Burkhard Hirsch

Publikováno v: Der Pathologe. 31:193-198

Stimulation of the TNF receptors CD30 and CD95 exerts opposite effects. Crosstalk of both receptors is unknown. We aimed to reveal regulatory mechanisms of CD30-induced effects on CD95 signaling of cALCL cell lines. "CD30/CD95 crosstalk analysis" was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c28a9e4a7d51b661c43f7dfb25931566
https://doi.org/10.1007/s00292-010-1372-4

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Resistance of Cutaneous Anaplastic Large-Cell Lymphoma Cells to Apoptosis by Death Ligands Is Enhanced by CD30-Mediated Overexpression of c-FLIP

Autor: Frank K. Braun, Horst Dürkop, Jürgen Eberle, Wolfram Sterry, Marshall E. Kadin, Chalid Assaf, Nadya Al-Yacoub, Burkhard Hirsch

Publikováno v: Journal of Investigative Dermatology. 130:826-840

Death ligands, including TNF-alpha, CD95L/FasL, and TRAIL, mediate safeguard mechanisms against tumor growth and critically contribute to lymphocyte homeostasis. We investigated death receptor-mediated apoptosis and CD30/CD95 crosstalk in four CD30-p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c963184a9152a23a4d673e35480712c1
https://doi.org/10.1038/jid.2009.299

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