Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy.

Autor: Horst BG; Department of Chemistry, University of California, Berkeley, Berkeley, United States., Yokom AL; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.; Graduate Group in Biophysics, University of California, Berkeley, Berkeley, United States., Rosenberg DJ; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, United States.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, United States., Morris KL; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.; Graduate Group in Biophysics, University of California, Berkeley, Berkeley, United States., Hammel M; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, United States., Hurley JH; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.; Graduate Group in Biophysics, University of California, Berkeley, Berkeley, United States.; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, United States.; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, United States., Marletta MA; Department of Chemistry, University of California, Berkeley, Berkeley, United States.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.; Graduate Group in Biophysics, University of California, Berkeley, Berkeley, United States.

Publikováno v: ELife [Elife] 2019 Sep 30; Vol. 8. Date of Electronic Publication: 2019 Sep 30.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Autor: Baragaña B; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Forte B; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Choi R; Seattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98109.; Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA 98109., Nakazawa Hewitt S; Seattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98109.; Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA 98109., Bueren-Calabuig JA; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Pisco JP; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Peet C; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Dranow DM; Seattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.; Beryllium Discovery Corp., Bainbridge Island, WA 98110., Robinson DA; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Jansen C; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Norcross NR; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Vinayak S; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602., Anderson M; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Brooks CF; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602., Cooper CA; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602., Damerow S; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Delves M; Department of Life Sciences, Imperial College, South Kensington, SW7 2AZ London, United Kingdom., Dowers K; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Duffy J; Medicines for Malaria Venture, 1215 Geneva 15, Switzerland., Edwards TE; Seattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.; Beryllium Discovery Corp., Bainbridge Island, WA 98110., Hallyburton I; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Horst BG; Seattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98109.; Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA 98109., Hulverson MA; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98109.; Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA 98109., Ferguson L; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Jiménez-Díaz MB; The Art of Discovery, 48160 Derio, Bizkaia, Basque Country, Spain., Jumani RS; Department of Medicine, University of Vermont, Burlington, VT 05405., Lorimer DD; Seattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.; Beryllium Discovery Corp., Bainbridge Island, WA 98110., Love MS; Biology Department, Calibr at Scripps Research, La Jolla, CA 92037., Maher S; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602., Matthews H; Department of Life Sciences, Imperial College, South Kensington, SW7 2AZ London, United Kingdom., McNamara CW; Biology Department, Calibr at Scripps Research, La Jolla, CA 92037., Miller P; Department of Medicine, University of Vermont, Burlington, VT 05405., O'Neill S; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Ojo KK; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98109.; Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA 98109., Osuna-Cabello M; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Pinto E; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Post J; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Riley J; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Rottmann M; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland.; Universität Basel, CH-4003 Basel, Switzerland., Sanz LM; Diseases of the Developing World, Global Health, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain., Scullion P; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Sharma A; Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, 110067 New Delhi, India., Shepherd SM; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Shishikura Y; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Simeons FRC; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Stebbins EE; Department of Medicine, University of Vermont, Burlington, VT 05405., Stojanovski L; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Straschil U; Department of Life Sciences, Imperial College, South Kensington, SW7 2AZ London, United Kingdom., Tamaki FK; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Tamjar J; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Torrie LS; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Vantaux A; Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, 12 201 Phnom Penh, Cambodia., Witkowski B; Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, 12 201 Phnom Penh, Cambodia., Wittlin S; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland.; Universität Basel, CH-4003 Basel, Switzerland., Yogavel M; Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, 110067 New Delhi, India., Zuccotto F; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Angulo-Barturen I; The Art of Discovery, 48160 Derio, Bizkaia, Basque Country, Spain., Sinden R; Department of Life Sciences, Imperial College, South Kensington, SW7 2AZ London, United Kingdom., Baum J; Department of Life Sciences, Imperial College, South Kensington, SW7 2AZ London, United Kingdom., Gamo FJ; Diseases of the Developing World, Global Health, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain., Mäser P; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland.; Universität Basel, CH-4003 Basel, Switzerland., Kyle DE; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602., Winzeler EA; Skaggs School of Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093.; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093., Myler PJ; Seattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109.; Department of Global Health, University of Washington, Seattle, WA 98195.; Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA 98195., Wyatt PG; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Floyd D; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada., Matthews D; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada., Sharma A; Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, 110067 New Delhi, India., Striepen B; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602.; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Huston CD; Department of Medicine, University of Vermont, Burlington, VT 05405., Gray DW; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Fairlamb AH; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Pisliakov AV; Computational Biology, School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom.; Physics, School of Science and Engineering, University of Dundee, Dundee DD1 4HN, United Kingdom., Walpole C; Structural Genomics Consortium, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada., Read KD; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom., Van Voorhis WC; Seattle Structural Genomics Center for Infectious Disease, Seattle, WA 98109.; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98109.; Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA 98109., Gilbert IH; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom; i.h.gilbert@dundee.ac.uk.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Apr 02; Vol. 116 (14), pp. 7015-7020. Date of Electronic Publication: 2019 Mar 20.

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.

Autor: Hewitt SN; Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington , 750 Republican Street, Seattle, Washington 98109, United States.; Seattle Structural Genomics Center for Infectious Disease (SSGCID) , Seattle, Washington 98109, United States., Dranow DM; Seattle Structural Genomics Center for Infectious Disease (SSGCID) , Seattle, Washington 98109, United States.; Beryllium Discovery Corporation , 7869 N.E. Day Road West, Bainbridge Island, Washington 98110, United States., Horst BG; Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington , 750 Republican Street, Seattle, Washington 98109, United States.; Seattle Structural Genomics Center for Infectious Disease (SSGCID) , Seattle, Washington 98109, United States., Abendroth JA; Seattle Structural Genomics Center for Infectious Disease (SSGCID) , Seattle, Washington 98109, United States.; Beryllium Discovery Corporation , 7869 N.E. Day Road West, Bainbridge Island, Washington 98110, United States., Forte B; Drug Discovery Unit (DDU), Division of Biological Chemistry and Drug Discovery, University of Dundee , Dundee DD1 5EH, United Kingdom., Hallyburton I; Drug Discovery Unit (DDU), Division of Biological Chemistry and Drug Discovery, University of Dundee , Dundee DD1 5EH, United Kingdom., Jansen C; Drug Discovery Unit (DDU), Division of Biological Chemistry and Drug Discovery, University of Dundee , Dundee DD1 5EH, United Kingdom., Baragaña B; Drug Discovery Unit (DDU), Division of Biological Chemistry and Drug Discovery, University of Dundee , Dundee DD1 5EH, United Kingdom., Choi R; Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington , 750 Republican Street, Seattle, Washington 98109, United States.; Seattle Structural Genomics Center for Infectious Disease (SSGCID) , Seattle, Washington 98109, United States., Rivas KL; Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington , 750 Republican Street, Seattle, Washington 98109, United States., Hulverson MA; Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington , 750 Republican Street, Seattle, Washington 98109, United States., Dumais M; Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington , 750 Republican Street, Seattle, Washington 98109, United States., Edwards TE; Seattle Structural Genomics Center for Infectious Disease (SSGCID) , Seattle, Washington 98109, United States.; Beryllium Discovery Corporation , 7869 N.E. Day Road West, Bainbridge Island, Washington 98110, United States., Lorimer DD; Beryllium Discovery Corporation , 7869 N.E. Day Road West, Bainbridge Island, Washington 98110, United States., Fairlamb AH; Drug Discovery Unit (DDU), Division of Biological Chemistry and Drug Discovery, University of Dundee , Dundee DD1 5EH, United Kingdom., Gray DW; Drug Discovery Unit (DDU), Division of Biological Chemistry and Drug Discovery, University of Dundee , Dundee DD1 5EH, United Kingdom., Read KD; Drug Discovery Unit (DDU), Division of Biological Chemistry and Drug Discovery, University of Dundee , Dundee DD1 5EH, United Kingdom., Lehane AM; Research School of Biology, The Australian National University , Acton, Australian Capital Territory 2601, Australia., Kirk K; Research School of Biology, The Australian National University , Acton, Australian Capital Territory 2601, Australia., Myler PJ; Seattle Structural Genomics Center for Infectious Disease (SSGCID) , Seattle, Washington 98109, United States.; Center for Infectious Disease Research , 307 Westlake Avenue North, Suite 500, Seattle, Washington 98109, United States.; Departments of Global Health and Biomedical Informatics and Medical Education, University of Washington , Seattle, Washington 98195, United States., Wernimont A; Structure-guided Drug Discovery Coalition (SDDC), Structural Genomic Consortium , 101 College Street, MaRS South Tower, Suite 700, Toronto, Ontario M5G 1L7, Canada., Walpole C; Structure-guided Drug Discovery Coalition (SDDC), Structural Genomic Consortium , 101 College Street, MaRS South Tower, Suite 700, Toronto, Ontario M5G 1L7, Canada., Stacy R; Seattle Structural Genomics Center for Infectious Disease (SSGCID) , Seattle, Washington 98109, United States.; Center for Infectious Disease Research , 307 Westlake Avenue North, Suite 500, Seattle, Washington 98109, United States., Barrett LK; Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington , 750 Republican Street, Seattle, Washington 98109, United States.; Seattle Structural Genomics Center for Infectious Disease (SSGCID) , Seattle, Washington 98109, United States., Gilbert IH; Drug Discovery Unit (DDU), Division of Biological Chemistry and Drug Discovery, University of Dundee , Dundee DD1 5EH, United Kingdom., Van Voorhis WC; Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington , 750 Republican Street, Seattle, Washington 98109, United States.; Seattle Structural Genomics Center for Infectious Disease (SSGCID) , Seattle, Washington 98109, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2017 Jan 13; Vol. 3 (1), pp. 34-44. Date of Electronic Publication: 2016 Nov 16.