Zobrazeno 1 - 10
of 994
pro vyhledávání: '"Horst, Kessler"'
Autor:
Stefano Cinti, Stefano Tomassi, Chiara Ciardiello, Rossella Migliorino, Marinella Pirozzi, Alessandra Leone, Elena Di Gennaro, Virginia Campani, Giuseppe De Rosa, Vincenzo Maria D’Amore, Salvatore Di Maro, Greta Donati, Sima Singh, Ada Raucci, Francesco Saverio Di Leva, Horst Kessler, Alfredo Budillon, Luciana Marinelli
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Despite progress in the prevention and diagnosis of cancer, current technologies for tumor detection present several limitations including invasiveness, toxicity, inaccuracy, lengthy testing duration and high cost. Therefore, innovative diag
Externí odkaz:
https://doaj.org/article/252fb9bb04114559aa178aea6715169a
Autor:
Alexandra Njegić, Lina Laid, Min Zi, Eleni Maniati, Jun Wang, Alexandru Chelu, Laura Wisniewski, Jenna Hunter, Sukhpal Prehar, Nicholas Stafford, Chaim Gilon, Amnon Hoffman, Michael Weinmüller, Horst Kessler, Elizabeth J. Cartwright, Kairbaan Hodivala-Dilke
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 8, Iss , Pp 100069- (2024)
Heart failure remains one of the largest clinical burdens globally, with little to no improvement in the development of disease-eradicating therapeutics. Integrin targeting has been used in the treatment of ocular disease and cancer, but little is kn
Externí odkaz:
https://doaj.org/article/a3900e0a7f874b28bce6fe50725d27f9
Autor:
Lea Jessica Flitsch, Kathleen Börner, Christian Stüllein, Simon Ziegler, Vera Sonntag-Buck, Ellen Wiedtke, Vesselina Semkova, Si Wah Christina Au Yeung, Julia Schlee, Mohamad Hajo, Mona Mathews, Beatrice Stefanie Ludwig, Susanne Kossatz, Horst Kessler, Dirk Grimm, Oliver Brüstle
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Human brain cells generated by in vitro cell programming provide exciting prospects for disease modeling, drug discovery and cell therapy. These applications frequently require efficient and clinically compliant tools for genetic modificatio
Externí odkaz:
https://doaj.org/article/4875817cf7bc4d6497c93a0dff7c11d4
Autor:
Jifeng Liu, Hongyan Long, Dagmar Zeuschner, Andreas F. B. Räder, William J. Polacheck, Horst Kessler, Lydia Sorokin, Britta Trappmann
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Current tissue engineering strategies lack materials that promote angiogenesis. Here the authors develop a microfluidic in vitro model in which chemokine-guided endothelial cell sprouting into a tunable hydrogel is followed by the formation of perfus
Externí odkaz:
https://doaj.org/article/44b2977179d84acea256312132cf8fe7
Autor:
Amelie Bauer, Matteo Puglisi, Dennis Nagl, Joel A Schick, Thomas Werner, Andreas Klingl, Jihad El Andari, Veit Hornung, Horst Kessler, Magdalena Götz, Dirk Grimm, Ruth Brack‐Werner
Publikováno v:
Advanced Science, Vol 9, Iss 16, Pp n/a-n/a (2022)
Abstract Astrocytes have crucial functions in the central nervous system (CNS) and are major players in many CNS diseases. Research on astrocyte‐centered diseases requires efficient and well‐characterized gene transfer vectors. Vectors derived fr
Externí odkaz:
https://doaj.org/article/5af49d6d446a4dbebfe51b5777d11b6c
Autor:
Pravin Kumar Ankush Jagtap, Tomáš Kubelka, Komal Soni, Cindy L. Will, Divita Garg, Claudia Sippel, Tobias G. Kapp, Harish Kumar Potukuchi, Kenji Schorpp, Kamyar Hadian, Horst Kessler, Reinhard Lührmann, Felix Hausch, Thorsten Bach, Michael Sattler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
So far only a few compounds have been reported as splicing modulators. Here, the authors combine high-throughput screening, chemical synthesis, NMR, X-ray crystallography with functional studies and develop phenothiazines as inhibitors for the U2AF H
Externí odkaz:
https://doaj.org/article/816cddccf4d4425e993bdca998fb63bd
Autor:
Dalia El Arawi, Cyrille Vézy, Régis Déturche, Maxime Lehmann, Horst Kessler, Monique Dontenwill, Rodolphe Jaffiol
Publikováno v:
Biophysical Reports, Vol 1, Iss 2, Pp 100021- (2021)
Over the last decades, several techniques have been developed to study cell adhesion; however, they present significant shortcomings. Such techniques mostly focus on strong adhesion related to specific protein-protein associations, such as ligand-rec
Externí odkaz:
https://doaj.org/article/5fe1e09a74694daf9b9ae4dbf3640987
Autor:
Jacopo Di Russo, Jennifer L Young, Julian WR Wegner, Timmy Steins, Horst Kessler, Joachim P Spatz
Publikováno v:
eLife, Vol 10 (2021)
Nanometer-scale properties of the extracellular matrix influence many biological processes, including cell motility. While much information is available for single-cell migration, to date, no knowledge exists on how the nanoscale presentation of extr
Externí odkaz:
https://doaj.org/article/932081bb1fa54e35a976399760cd037f
Autor:
Johannes Notni, Florian T. Gassert, Katja Steiger, Peter Sommer, Wilko Weichert, Ernst J. Rummeny, Markus Schwaiger, Horst Kessler, Reinhard Meier, Melanie A. Kimm
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-9 (2019)
Abstract Background Rheumatoid arthritis (RA) is one of the most common rheumatic diseases. Joint inflammation and pathological growth of joint cartilage cause swollen and painful joints, which severely diminishes the patients’ life quality. There
Externí odkaz:
https://doaj.org/article/89f07b97fd9f426d999d8d6212a268bf
Autor:
Margret Schottelius, Marina Ludescher, Frauke Richter, Tobias G. Kapp, Horst Kessler, Hans-Jürgen Wester
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-9 (2019)
Abstract Background The development and clinical translation of [68Ga] Pentixafor has substantially promoted the relevance of non-invasive PET imaging of CXCR4 expression in a broad spectrum of diseases, including cancer and inflammation. Its pronoun
Externí odkaz:
https://doaj.org/article/e89eed2cb3c34ab1a5ef058faafa039c