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Akademický článek

Differential impact of oleate, palmitate, and adipokines on expression of NF-κB target genes in human vascular smooth muscle cells

Autor: Lamers, Daniela, Schlich, Raphaela, Horrighs, Angelika, Cramer, Andrea, Sell, Henrike, Eckel, Juergen

Publikováno v: In Molecular and Cellular Endocrinology 15 October 2012 362(1-2):194-201

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Akademický článek

Hypoxia reduces the response of human adipocytes towards TNFα resulting in reduced NF-κB signaling and MCP-1 secretion.

Autor: Famulla, S¹, Horrighs, A¹, Cramer, A¹, Sell, H¹, Eckel, J¹

Publikováno v: International Journal of Obesity. Jul2012, Vol. 36 Issue 7, p986-992. 7p.

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Differential impact of oleate, palmitate, and adipokines on expression of NF-κB target genes in human vascular smooth muscle cells

Autor: Daniela Lamers, Henrike Sell, A Horrighs, Juergen Eckel, Raphaela Schlich, A Cramer

Publikováno v: Molecular and Cellular Endocrinology. 362:194-201

It is widely accepted that obesity is a major risk factor for the development of atherosclerosis. In this context, adipose tissue produces a variety of adipokines and releases free fatty acids, contributing to a chronic-low grade inflammation state i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056deb839c0ab9f836b5b52651507596
https://doi.org/10.1016/j.mce.2012.06.010

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Hypoxia reduces the response of human adipocytes towards TNFα resulting in reduced NF-κB signaling and MCP-1 secretion

Autor: A Horrighs, A Cramer, Susanne Famulla, Jürgen Eckel, Henrike Sell

Publikováno v: International Journal of Obesity. 36:986-992

Obesity is associated with adipose tissue hypoxia, and is thought to be linked to the chronic low-grade inflammation of adipose tissue, although the precise mechanism has remained unclear. In this study, we investigated the effect of a prominent hypo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13086be47e89dcaab60604db7c738f45
https://doi.org/10.1038/ijo.2011.200

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Chemerin Is a Novel Adipocyte-Derived Factor Inducing Insulin Resistance in Primary Human Skeletal Muscle Cells

Autor: Jurga Laurencikiene, A Horrighs, Henrike Sell, Kristin Eckardt, Peter Arner, A Cramer, Annika Taube, Jürgen Eckel

Publikováno v: Diabetes; Vol 58
Diabetes

OBJECTIVE Chemerin is an adipokine that affects adipogenesis and glucose homeostasis in adipocytes and increases with BMI in humans. This study was aimed at investigating the regulation of chemerin release and its effects on glucose metabolism in ske

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5593a604baf30578d47db4a6b33ac734

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Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle

Autor: Kristin Eckardt, B. Platzbecker, Marko Lehtonen, M. Koenen, Norbert Tennagels, A Horrighs, Annika Taube, Henrike Sell, Jürgen Eckel, A Cramer

Publikováno v: Diabetologia. 52:664-674

Cannabinoid type 1 receptor (CB1R) antagonists such as rimonabant (Rim) represent a novel approach to treat obesity and related metabolic disorders. Recent data suggest that endocannabinoids are also produced by human adipocytes. Here we studied the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8a47a0d2b78f1e5f52ad3d2a6cf629
https://doi.org/10.1007/s00125-008-1240-4

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Over-expression of PRAS40 enhances insulin sensitivity in skeletal muscle

Autor: Angelika Horrighs, Annette Schürmann, Claudia Wiza, D. Margriet Ouwens, Daniella Herzfeld de Wiza, Marcel Blumensatt, Emmani B.M. Nascimento, Alexandra Chadt, Hadi Al-Hasani, Timo Kanzleiter, Heidi Mueller

Publikováno v: Archives of physiology and biochemistry. 120(2)

Silencing proline-rich Akt substrate of 40-kDa (PRAS40) impairs insulin signalling in skeletal muscle.This study assessed the effects of over-expressing wild type or mutant AAA-PRAS40, in which the major phosphorylation sites and mTORC1-binding site

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae931369e36be4095e95ac2dcf4374f
https://pubmed.ncbi.nlm.nih.gov/24576065

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Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells

Autor: Daniela Lamers, A Horrighs, Henrike Sell, A Cramer, Stefan Lehr, Jürgen Eckel, Susanne Famulla, Waltraud Passlack, Sonja Hartwig

Publikováno v: International journal of obesity (2005). 35(6)

Pigment epithelium-derived factor (PEDF) is a multifunctional protein with neurotrophic and anti-angiogenic properties. More recently it became evident that PEDF is upregulated in patients with type 2 diabetes and also contributes to insulin resistan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da2b6466a48ea577f7905fe6ae420ea
https://pubmed.ncbi.nlm.nih.gov/20938440

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