Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Horng-Yuan Kan"'
Autor:
Van Vo, Anthony Harrington, Salman Afzal, Katerina Papp, Ching-Lan Chang, Hayley Baker, Perseveranda Aguilar, Erin Buttery, Michael A. Picker, Cassius Lockett, Daniel Gerrity, Horng-Yuan Kan, Edwin C. Oh
Publikováno v:
The Science of the total environment. 858(Pt 3)
The identification of novel SARS-CoV-2 variants can predict new patterns of COVID-19 community transmission and lead to the deployment of public health resources. However, increased access to at-home antigen tests and reduced free PCR tests have rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef03ff62ab0e1385f1ee4bc6ef27f3c0
https://pubmed.ncbi.nlm.nih.gov/36356728
https://pubmed.ncbi.nlm.nih.gov/36356728
Publikováno v:
Biochemistry. 44:4108-4117
The objective of this study was to determine the effect of two amino-terminal apolipoprotein A-I (apoA-I) deletions on high-density lipoprotein (HDL) biosynthesis and lipid homeostasis. Adenovirus-mediated gene transfer showed that the apoA-I[Delta(8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167d703e769072f7216ef8004405ffaa
https://doi.org/10.1021/bi047998l
https://doi.org/10.1021/bi047998l
Autor:
Horng-Yuan Kan, and Adelina Shkodrani, Vassilis I. Zannis, Kyriakos E. Kypreos, Irina N. Gorshkova, Angeliki Chroni
Publikováno v:
Biochemistry. 43:10442-10457
Hypertriglyceridemia is a common pathological condition in humans of mostly unknown etiology. Here we report induction of dyslipidemia characterized by severe hypertriglyceridemia as a result of point mutations in human apolipoprotein A-I (apoA-I). A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb00b92ef754ce361edb18e4e58016f0
https://doi.org/10.1021/bi049782p
https://doi.org/10.1021/bi049782p
Autor:
Vassilis I. Zannis, Horng-Yuan Kan, Spiros Georgopoulos, Adelina Shkodrani, Markella V. Zanni, Alexandros Tzatsos, Hou Xiang Xie
Publikováno v:
Biochemistry. 43:5084-5093
We have generated and studied the pattern of expression of transgenic mouse lines carrying the human apoA-I and apoCIII gene cluster mutated at different sites. In two lines, we have either mutated the hormone-response element (HRE) of element G of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1387dfdfd767c7f298fbc0dd01893a8
https://doi.org/10.1021/bi035764g
https://doi.org/10.1021/bi035764g
Autor:
Yoshinari Uehara, Vassilis I. Zannis, Angeliki Chroni, Arnold von Eckardstein, Horng-Yuan Kan, Tong Liu, Irina N. Gorshkova
Publikováno v:
Journal of Biological Chemistry. 278:6719-6730
We have mapped the domains of lipid-free apoA-I that promote cAMP-dependent and cAMP-independent cholesterol and phospholipid efflux. The cAMP-dependent lipid efflux in J774 mouse macrophages was decreased by ∼80–92% by apoA-I[Δ(185–243)], onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0392a1c890ce27d00f0b85d027210d03
https://doi.org/10.1074/jbc.m205232200
https://doi.org/10.1074/jbc.m205232200
Publikováno v:
Biochemistry. 41:9293-9301
Apolipoprotein E (apoE) isoforms are key determinants of susceptibility to late-onset Alzheimer's disease (AD). The epsilon 4 and epsilon 2 alleles have been associated with increased and decreased risk for AD, respectively. We have generated and cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e6845be60dfbe4518d1394fc03bb20
https://doi.org/10.1021/bi015971l
https://doi.org/10.1021/bi015971l
Publikováno v:
Journal of Biological Chemistry. 277:21576-21584
We have studied the effects of mutations in apoA-I on reconstituted high density lipoprotein (HDL) particle (rHDL(apoA-I)) binding to and cholesterol efflux from wild-type (WT) and mutant forms of the HDL receptor SR-BI expressed by ldlA-7 cells. Mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4b5e46906997a12124d1dd1950473e
https://doi.org/10.1074/jbc.m112103200
https://doi.org/10.1074/jbc.m112103200
Autor:
Godfrey S. Getz, Horng-Yuan Kan, Blachowicz L, Lukens, Wu Q, Kalliopi Liadaki, Vassilis I. Zannis, Catherine A. Reardon, Cabana
Publikováno v:
Biochemistry. 40:13670-13680
We have used adenovirus-mediated gene transfer in apoA-I-deficient (A-I-/-) mice to probe the in vivo assembly and metabolism of HDL using apoA-I variants, focusing primarily on the role of the C-terminal 32 amino acids (helices 9-10). Lipid, lipopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfdb606bc0a90d326701fc7d3f21936f
https://doi.org/10.1021/bi011451e
https://doi.org/10.1021/bi011451e
Publikováno v:
Journal of Biological Chemistry. 275:30423-30431
We have generated transgenic mice carrying wild-type promoters of the human apolipoprotein A-I (apoA-I)-apoCIII gene cluster or promoters mutated in their hormone response elements. The wild-type cluster directed high levels of apoA-I gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af09aaf42dd7a49d6724d1a3576bbeb
https://doi.org/10.1074/jbc.m005641200
https://doi.org/10.1074/jbc.m005641200
Publikováno v:
Nucleic Acids Research. 27:1104-1117
DNase I footprinting of the apoA-II promoter using sterol regulatory element binding protein-2 [(SREBP-2 (1-458)] expressed in bacteria identified four protected regions, designated AIIAB (-64 to -48), AIICD (-178 to -154), AIIDE (-352 to -332) and A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2568c9115a109066f1e4fec65e3abcc
https://doi.org/10.1093/nar/27.4.1104
https://doi.org/10.1093/nar/27.4.1104