Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Horng‐Dar Wang"'
Autor:
Chen-Sheng Wu, Bo-Han Chen, Hiu-Lo Cheng, Wei-Ming Huang, Tian-Neng Li, Horng-Dar Wang, Chun-Hsien Kuo
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 38, Iss 1 (2024)
The global dissemination of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) Omicron variants has been characterized by a distinct 9-base pair (bp) deletion within the nucleocapsid (N) gene, a genomic feature absent in previously cir
Externí odkaz:
https://doaj.org/article/33cc6517f64745f3b14cfaf5a23461c5
Autor:
Shao-Wei Pan, Horng-Dar Wang, He-Yun Hsiao, Po-Jui Hsu, Yung-Che Tseng, Wen-Chen Liang, Yuh-Jyh Jong, Chiou-Hwa Yuh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Lamin A/C gene (LMNA) mutations contribute to severe striated muscle laminopathies, affecting cardiac and skeletal muscles, with limited treatment options. In this study, we delve into the investigations of five distinct LMNA mutations, incl
Externí odkaz:
https://doaj.org/article/2369a1c7bd9142cbbafe31b4891e0e66
l-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish
Autor:
Po-Jui Hsu, Horng-Dar Wang, Yung-Che Tseng, Shao-Wei Pan, Bonifasius Putera Sampurna, Yuh-Jyh Jong, Chiou-Hwa Yuh
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-21 (2021)
Abstract Background Congenital myopathy (CM) is a group of clinically and genetically heterogeneous muscle disorders, characterized by muscle weakness and hypotonia from birth. Currently, no definite treatment exists for CM. A de novo mutation in Tro
Externí odkaz:
https://doaj.org/article/30716d4cf73a4a8c930c447fab6e3f6c
Autor:
Po-Lin Chen, Kai-Ting Huang, Chu-Ya Cheng, Jian-Chiuan Li, Hsiao-Yen Chan, Tzu-Yang Lin, Matthew P. Su, Wei-Yuan Yang, Henry C. Chang, Horng-Dar Wang, Chun-Hong Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Mitochondrial dynamics change during ageing, with larger mitochondria and altered protein import in older animals. Here the authors show that Dosmit protein mediates mitochondrial morphology with Rab32 by inducing double-membraned vesicles that regul
Externí odkaz:
https://doaj.org/article/666dd2760252480d98caf0dd4c44a027
Autor:
Wen-Chi Shen, Chiou-Hwa Yuh, Yu-Ting Lu, Yen-Hung Lin, Tsui-Ting Ching, Chao-Yung Wang, Horng-Dar Wang
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 124 (2023)
Deregulation of redox homeostasis is often associated with an accelerated aging process. Ribose-5-phosphate isomerase A (RPIA) mediates redox homeostasis in the pentose phosphate pathway (PPP). Our previous study demonstrated that Rpi knockdown boost
Externí odkaz:
https://doaj.org/article/8c0ecf7a0d92447a819df5e7945118ed
Autor:
Sung-Tau Chou, Hsuan-Yu Peng, Kuan-Chi Mo, Yuan-Ming Hsu, Guan-Hsun Wu, Jenn-Ren Hsiao, Su-Fang Lin, Horng-Dar Wang, Shine-Gwo Shiah
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background Discoidin domain receptor-1 (DDR1) tyrosine kinase is highly expressed in a variety of human cancers and involved in various steps of tumorigenesis. However, the precise mechanisms underlying the abnormal expression of DDR1 in ora
Externí odkaz:
https://doaj.org/article/153c868dcc614b069a17bec55af4cc54
Autor:
Hsing-Han Li, Yu Cai, Jian-Chiuan Li, Matthew P. Su, Wei-Liang Liu, Lie Cheng, Shu-Jen Chou, Guann-Yi Yu, Horng-Dar Wang, Chun-Hong Chen
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101486- (2020)
Summary: Physiological trade-offs between mosquito immune response and reproductive capability can arise due to insufficient resource availability. C-type lectin family members may be involved in these processes. We established a GCTL-3−/− mutant
Externí odkaz:
https://doaj.org/article/edbd026ed0e8478c90358c7773849df3
Publikováno v:
Diagnostics, Vol 12, Iss 1, p 203 (2022)
Bladder cancer has been increasing globally. Urinary cytology is considered a major screening method for bladder cancer, but it has poor sensitivity. This study aimed to utilize clinical laboratory data and machine learning methods to build predictiv
Externí odkaz:
https://doaj.org/article/0c2a5c84754e453abdedc277d226169d
Autor:
Yu-Ting Chou, Jeng-Kai Jiang, Muh-Hwa Yang, Jeng-Wei Lu, Hua-Kuo Lin, Horng-Dar Wang, Chiou-Hwa Yuh
Publikováno v:
PLoS Biology, Vol 16, Iss 1, p e2003714 (2018)
Altered metabolism is one of the hallmarks of cancers. Deregulation of ribose-5-phosphate isomerase A (RPIA) in the pentose phosphate pathway (PPP) is known to promote tumorigenesis in liver, lung, and breast tissues. Yet, the molecular mechanism of
Externí odkaz:
https://doaj.org/article/2b0991300b044d5da2320b155040d392
Publikováno v:
Cells, Vol 8, Iss 4, p 295 (2019)
Patients receiving docetaxel developed a drug resistance within a few months. We generated docetaxel-resistant PC/DX25 and DU/DX50 CRPC cells from PC-3 and DU-145 PCa cells, respectively. We investigated the mechanism behind why PC/DX25 and DU/DX50 c
Externí odkaz:
https://doaj.org/article/74778620261241d0960f9f020d1d9a5a