Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Hormoz Mazdiyasni"'
Autor:
Jana R. Jenquin, Alana P. O’Brien, Kiril Poukalov, Yidan Lu, Jesus A. Frias, Hannah K. Shorrock, Jared I. Richardson, Hormoz Mazdiyasni, Hongfen Yang, Robert W. Huigens, III, David Boykin, Laura P.W. Ranum, John Douglas Cleary, Eric T. Wang, J. Andrew Berglund
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104198- (2022)
Summary: Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are common forms of adult onset muscular dystrophy. Pathogenesis in both diseases is largely driven by production of toxic-expanded repeat RNAs that sequester MBNL RNA-binding proteins, causin
Externí odkaz:
https://doaj.org/article/58816a4f83314c1bbc07ac1339b064d0
Autor:
Ameya R. Kirtane, Omar Abouzid, Daniel Minahan, Taylor Bensel, Alison L. Hill, Christian Selinger, Anna Bershteyn, Morgan Craig, Shirley S. Mo, Hormoz Mazdiyasni, Cody Cleveland, Jaimie Rogner, Young-Ah Lucy Lee, Lucas Booth, Farhad Javid, Sarah J. Wu, Tyler Grant, Andrew M. Bellinger, Boris Nikolic, Alison Hayward, Lowell Wood, Philip A. Eckhoff, Martin A. Nowak, Robert Langer, Giovanni Traverso
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Poor adherence to daily antiretrovirals can significantly affect treatment efficacy, but oral long-acting antiretrovirals are currently lacking. Here, the authors develop a once-weekly oral dosage form for anti-HIV drugs, assess its pharmacokinetics
Externí odkaz:
https://doaj.org/article/5de2bff495f541e8ae208242e10f066e
Autor:
Jinyao Liu, Yan Pang, Shiyi Zhang, Cody Cleveland, Xiaolei Yin, Lucas Booth, Jiaqi Lin, Young-Ah Lucy Lee, Hormoz Mazdiyasni, Sarah Saxton, Ameya R. Kirtane, Thomas von Erlach, Jaimie Rogner, Robert Langer, Giovanni Traverso
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The use of drug delivery systems for the gastrointestinal tract has been faced with a number of drawbacks related to their prolonged use. Here, the authors develop a drug-loaded hydrogel with high strength to withstand long-term gastrointestinal moti
Externí odkaz:
https://doaj.org/article/7f4463389f3940b0989734721e7106d0
Autor:
Jana R. Jenquin, Alana P. O’Brien, Kiril Poukalov, Yidan Lu, Jesus A. Frias, Hannah K. Shorrock, Jared I. Richardson, Hormoz Mazdiyasni, Hongfen Yang, Robert W. Huigens, David Boykin, Laura P.W. Ranum, John Douglas Cleary, Eric T. Wang, J. Andrew Berglund
Publikováno v:
iScience. 25(5)
Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are common forms of adult onset muscular dystrophy. Pathogenesis in both diseases is largely driven by production of toxic-expanded repeat RNAs that sequester MBNL RNA-binding proteins, causing mis-spl
Autor:
Sahab Babaee, Kaitlyn Hess, Jiuyun Shi, Ameya R. Kirtane, Alison Hayward, Aniket Wahane, Robert Langer, Giovanni Traverso, Simo Pajovic, Siddartha Tamang, Joy Collins, Hormoz Mazdiyasni, Ester Caffarel-Salvador
Publikováno v:
Science Translational Medicine. 11
We hypothesized that ingested warm fluids could act as triggers for biomedical devices. We investigated heat dissipation throughout the upper gastrointestinal (GI) tract by administering warm (55°C) water to pigs and identified two zones in which th
Autor:
Anuj Bhatnagar, Dalia Leibowitz, Sunil D. Khaparde, Shelly Batra, Vance Soares, Ellena Popova, Gal Zeidman, Robert Stoner, Malvika Verma, Christoph Steiger, Castaneda Macy, Tiffany Hua, Niclas Roxhed, Taylor Bensel, Manju Bajiya, Daniel Minahan, Cody Cleveland, Andrew Bellinger, Joy Collins, Aaron Lopes, Sandeep Ahuja, Elizabeth Mule, Upasna Agarwal, Robert Langer, Giovanni Traverso, Rohit Sarin, Deepak Gupta, Sonali Batra, Neeraj Gupta, Nandini Sharma, Chinonyelum Ikeanyi, Sooraj Boominathan, Daniel J. Fulop, Tyler Grant, Jonathan B. Miller, Ashwani Khanna, K K Chopra, Siddartha Tamang, Hormoz Mazdiyasni, Feyisope Eweje, David Collins, Jayeeta Chowdhury, Michael J. Cima, John A. F. Salama, Karan Vishwanath, Alison Hayward, Kaitlyn Hess, Alexander H. Slocum, Jennifer Furin
Publikováno v:
Science Translational Medicine
Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To addre
Autor:
Kensuke Tateishi, Erik A. Williams, Joshua M. Francis, Jochen K. Lennerz, Anthony J. Iafrate, Julie M. Batten, Hiroaki Wakimoto, Koerner Mva, Fumi Higuchi, Tracy T. Batchelor, Stephen P. Schmidt, Barker Fg nd, Aymen Baig, Gregory R. Wojtkiewicz, Andrew S. Chi, Tai Tammy, Priscilla K. Brastianos, Tristan Penson, Robert Langer, Giovanni Traverso, William T. Curry, Shilpa S. Tummala, Julie J. Miller, Ameya R. Kirtane, Mikael L. Rinne, Jaimie Rogner, Matthew Meyerson, Hormoz Mazdiyasni, Daniel P. Cahill, Avner Fink, Ganesh M. Shankar, Justin T. Jordan, Tareq A. Juratli
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Aggressive neurosurgical resection to achieve sustained local control is essential for prolonging survival in patients with lower-grade glioma. However, progression in many of these patients is characterized by local regrowth. Most lower-grade glioma
Autor:
Jinyao Liu, Yan Pang, Shiyi Zhang, Cody Cleveland, Xiaolei Yin, Lucas Booth, Jiaqi Lin, Young-Ah Lucy Lee, Hormoz Mazdiyasni, Sarah Saxton, Ameya R. Kirtane, Thomas von Erlach, Jaimie Rogner, Robert Langer, Giovanni Traverso
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Systems capable of residing for prolonged periods of time in the gastric cavity have transformed our ability to diagnose and treat patients. Gastric resident systems for drug delivery, ideally need to be: ingestible, be able to change shape or swell
Autor:
Prasoon Chaturvedi, Erica Evans, Russell Karp, Matthew T. Labenski, Heather Lounsbury, Martin I. Freed, Steven Richard Witowski, Hormoz Mazdiyasni, Richland Wayne Tester, M. Nacht, Sharon Aslanian, Michael Sheets, Russell C. Petter, Juswinder Singh, Zhendong Zhu, Alex Dubrovskiy, William F. Westlin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 346:219-228
Targeted therapies that suppress B cell receptor (BCR) signaling have emerged as promising agents in autoimmune disease and B cell malignancies. Bruton's tyrosine kinase (Btk) plays a crucial role in B cell development and activation through the BCR
Autor:
Hormoz Mazdiyasni, Prasoon Chaturvedi, Aravind Prasad Medikonda, Lixin Qiao, Thia St Martin, Juswinder Singh, Russell C. Petter, Deqiang Niu, Zhendong Zhu, William F. Westlin, Michael Sheets, Deepa Bhavsar, Matthew T. Labenski, Russell Karp, M. Nacht
Publikováno v:
Journal of Medicinal Chemistry. 56:712-721
PI3Kα has been identified as an oncogene in human tumors. By use of rational drug design, a targeted covalent inhibitor 3 (CNX-1351) was created that potently and specifically inhibits PI3Kα. We demonstrate, using mass spectrometry and X-ray crysta