Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Hormas Ghadially"'
Autor:
Elin Bernson, Oisín Huhn, Veronika Karlsson, Delia Hawkes, Maria Lycke, Valentina Cazzetta, Joanna Mikulak, James Hall, Anna M. Piskorz, Rosalba Portuesi, Domenico Vitobello, Barbara Fiamengo, Gabriele Siesto, Amir Horowitz, Hormas Ghadially, Domenico Mavilio, James D. Brenton, Karin Sundfeldt, Francesco Colucci
Publikováno v:
Cancers, Vol 15, Iss 13, p 3362 (2023)
Women with ovarian cancer have limited therapy options, with immunotherapy being unsatisfactory for a large group of patients. Tumor cells spread from the ovary or the fallopian tube into the abdominal cavity, which is commonly accompanied with massi
Externí odkaz:
https://doaj.org/article/8843f4bc76b94b51acedea33fa22106e
Autor:
Simon Smith, Hormas Ghadially, Kevin J Harrington, Alan A Melcher, Isla Leslie, Eva Crespo-Rodriguez, Galabina Bozhanova, Emmanuel C Patin, Harriet Whittock, Martin McLaughlin, Malin Pedersen, James Harper, Pablo Nenclares, Heba Soliman, Magnus T Dillon, Lorna Grove, Davina Northcote, Holly Baldock, Gabriella Baker, Joan Kyula, Jeane Guevara
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Despite therapeutic gains from immune checkpoint inhibitors (ICI) in many tumor types, new strategies are needed to extend treatment benefits, especially in patients failing to mount effective antitumor T-cell responses. Radiation and drug
Externí odkaz:
https://doaj.org/article/352213c6f2484a688ddb7a66accbad6a
Autor:
Oisín Huhn, Martin A. Ivarsson, Lucy Gardner, Mike Hollinshead, Jane C Stinchcombe, Puran Chen, Norman Shreeve, Olympe Chazara, Lydia E. Farrell, Jakob Theorell, Hormas Ghadially, Peter Parham, Gillian Griffiths, Amir Horowitz, Ashley Moffett, Andrew M. Sharkey, Francesco Colucci
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
As an interface between maternal and fetal tissues, decidua hosts immune cells specialized in fostering a successful pregnancy. Here the authors carry out high-dimensional characterization of function, morphology and surface markers of human decidual
Externí odkaz:
https://doaj.org/article/686fd2691411467caa9337f1f7add0f8
Autor:
Robert W Wilkinson, Hormas Ghadially, Stacy Kentner, Suzanne Isabelle Sitnikova, Sophie Munnings-Tomes, Elena Galvani, Kathy Mulgrew, Chris Rands, Judit España Agustí, Tianhui Zhang, Kristina M Ilieva, Guglielmo Rosignoli, Matthew J Robinson, Tim Slidel, Simon J Dovedi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Immuno-oncology therapies are now part of the standard of care for cancer in many indications. However, durable objective responses remain limited to a subset of patients. As such, there is a critical need to identify biomarkers that can p
Externí odkaz:
https://doaj.org/article/0daba65ab2174eb2906d5b3b2486abf0
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Immunotherapy has transformed cancer treatment by promoting durable clinical responses in a proportion of patients; however, treatment still fails in many patients. Innate immune cells play a key role in the response to immunotherapy. Crosstalk betwe
Externí odkaz:
https://doaj.org/article/560a35ae1d714434b97c8063590362a9
Autor:
Hormas Ghadially, Meir Ohana, Moran Elboim, Roi Gazit, Chamutal Gur, Arnon Nagler, Ofer Mandelboim
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 1809-1814 (2014)
Hematopoietic stem cell transplantation (HSCT) is often the only curative treatment for a wide variety of hematologic malignancies. Donor selection in these diseases is crucial, given that transplanted cells can mediate not only the desired graft-ver
Externí odkaz:
https://doaj.org/article/30c3b722384447cd97b2827dfb5a654a
Publikováno v:
The Scientific World Journal, Vol 2012 (2012)
Pattern recognition receptors are crucial in initiating and shaping innate and adaptive immune responses and often belong to families of structurally and evolutionarily related proteins. The human C-type lectin-like receptors encoded in the DECTIN-1
Externí odkaz:
https://doaj.org/article/0a680ec381304fbeb38a5e99557084b8
Autor:
Shirin Elhaik-Goldman, Daniel Kafka, Rami Yossef, Uzi Hadad, Moshe Elkabets, Alexandra Vallon-Eberhard, Luai Hulihel, Steffen Jung, Hormas Ghadially, Alex Braiman, Ron N Apte, Ofer Mandelboim, Ron Dagan, Yaffa Mizrachi-Nebenzahl, Angel Porgador
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23472 (2011)
Natural killer (NK) cells serve as a crucial first line of defense against tumors, viral and bacterial infections. We studied the involvement of a principal activating natural killer cell receptor, natural cytotoxicity receptor 1 (NCR1), in the innat
Externí odkaz:
https://doaj.org/article/7d246dad28934f37a92a20806a227238
Autor:
Aatman S. Doshi, Susan Cantin, Marylens Hernandez, Srimathi Srinivasan, Sharon Tentarelli, Matthew Griffin, Yanjun Wang, Petar Pop-Damkov, Laura B. Prickett, Cecilia Kankkonen, Minhui Shen, Maryann San Martin, Song Wu, M. Paola Castaldi, Hormas Ghadially, Jeffrey Varnes, Sonya Gales, David Henry, Clare Hoover, Deanna A. Mele, Iain Simpson, Eric T. Gangl, Scott N. Mlynarski, M. Raymond V. Finlay, Lisa Drew, Stephen E. Fawell, Wenlin Shao, Alwin G. Schuller
Publikováno v:
Molecular Cancer Therapeutics. 22:630-645
Antitumor immunity can be hampered by immunosuppressive mechanisms in the tumor microenvironment, including recruitment of arginase (ARG) expressing myeloid cells that deplete l-arginine essential for optimal T-cell and natural killer cell function.
Autor:
Colucci, Elin Bernson, Oisín Huhn, Veronika Karlsson, Delia Hawkes, Maria Lycke, Valentina Cazzetta, Joanna Mikulak, James Hall, Anna M. Piskorz, Rosalba Portuesi, Domenico Vitobello, Barbara Fiamengo, Gabriele Siesto, Amir Horowitz, Hormas Ghadially, Domenico Mavilio, James D. Brenton, Karin Sundfeldt, Francesco
Publikováno v:
Cancers; Volume 15; Issue 13; Pages: 3362
Women with ovarian cancer have limited therapy options, with immunotherapy being unsatisfactory for a large group of patients. Tumor cells spread from the ovary or the fallopian tube into the abdominal cavity, which is commonly accompanied with massi