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Discovery of novel 2′,4′-dimethyl-[4,5′-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 1

Autor: Tsuno, Naoki, Yukimasa, Akira, Yoshida, Osamu, Ichihashi, Yusuke, Inoue, Takatsugu, Ueno, Tatsuhiko, Yamaguchi, Hiroki, Matsuda, Hidetoshi, Funaki, Satoko, Yamanada, Natsue, Tanimura, Miki, Nagamatsu, Daiki, Nishimura, Yoko, Ito, Tetsuji, Soga, Masahiko, Horita, Narumi, Yamamoto, Miyuki, Hinata, Mikie, Imai, Masayuki, Morioka, Yasuhide, Kanemasa, Toshiyuki, Sakaguchi, Gaku, Iso, Yasuyoshi

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 15 October 2016 26(20):4930-4935

Pharmacologic effects of naldemedine, a peripherally acting μ‐opioid receptor antagonist, in in vitro and in vivo models of opioid‐induced constipation.

Autor: Kanemasa, Toshiyuki, Koike, Katsumi, Arai, Tohko, Ono, Hiroko, Horita, Narumi, Chiba, Hiroki, Nakamura, Atsushi, Morioka, Yasuhide, Kihara, Tsuyoshi, Hasegawa, Minoru

Publikováno v: Neurogastroenterology & Motility; May2019, Vol. 31 Issue 5, pN.PAG-N.PAG, 1p

Suppression of joint pain in transient receptor potential vanilloid 4 knockout rats with monoiodoacetate-induced osteoarthritis.

Autor: Soga M; Department of Pharmacological Efficacy Evaluation, Shionogi TechnoAdvance Research Co. Ltd., Toyonaka, Japan., Izumi T; Laboratory for Drug Discovery and Disease Research, Shionogi & Co. Ltd., Toyonaka, Japan., Nanchi I; Laboratory for Drug Discovery and Disease Research, Shionogi & Co. Ltd., Toyonaka, Japan., Horita N; Department of Pharmacological Efficacy Evaluation, Shionogi TechnoAdvance Research Co. Ltd., Toyonaka, Japan., Yamamoto M; Laboratory for Drug Discovery and Disease Research, Shionogi & Co. Ltd., Toyonaka, Japan., Kawasaki S; Laboratory for Drug Discovery and Disease Research, Shionogi & Co. Ltd., Toyonaka, Japan., Ogawa K; Laboratory for Drug Discovery and Disease Research, Shionogi & Co. Ltd., Toyonaka, Japan., Fujita M; Laboratory for Drug Discovery and Disease Research, Shionogi & Co. Ltd., Toyonaka, Japan., Morioka Y; Laboratory for Drug Discovery and Disease Research, Shionogi & Co. Ltd., Toyonaka, Japan.

Publikováno v: Pain reports [Pain Rep] 2021 Aug 09; Vol. 6 (3), pp. e951. Date of Electronic Publication: 2021 Aug 09 (Print Publication: 2021).