Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Horia Todor"'
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 11, Pp 1173-1186 (2024)
Abstract Chemical genomics is a powerful and increasingly accessible technique to probe gene function, gene–gene interactions, and antibiotic synergies and antagonisms. Indeed, multiple large-scale pooled datasets in diverse organisms have been pub
Externí odkaz:
https://doaj.org/article/ebd26242553a438b9aaecebf6fab70ca
Autor:
Kristine L Trotta, Beth M Hayes, Johannes P Schneider, Jing Wang, Horia Todor, Patrick Rockefeller Grimes, Ziyi Zhao, William L Hatleberg, Melanie R Silvis, Rachel Kim, Byoung Mo Koo, Marek Basler, Seemay Chou
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011454 (2023)
Gram-negative bacteria can antagonize neighboring microbes using a type VI secretion system (T6SS) to deliver toxins that target different essential cellular features. Despite the conserved nature of these targets, T6SS potency can vary across recipi
Externí odkaz:
https://doaj.org/article/74bedf1958784e718ff4720b9a8dfd19
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Recent studies in bacteria have suggested that the broadly conserved but enigmatic DedA proteins function as undecaprenyl-phosphate (UndP) flippases, recycling this essential lipid carrier. To determine whether all DedA proteins have UndP fl
Externí odkaz:
https://doaj.org/article/7037ec1f6c5446e986d8287f82711ddd
Autor:
Melanie R. Silvis, Manohary Rajendram, Handuo Shi, Hendrik Osadnik, Andrew N. Gray, Spencer Cesar, Jason M. Peters, Cameron C. Hearne, Parth Kumar, Horia Todor, Kerwyn Casey Huang, Carol A. Gross
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Essential genes make up only ∼5 to 10% of the genetic complement in most organisms but occupy much of their protein synthesis and account for almost all antibiotic targets. Despite the importance of essential genes, their intractability has, until
Externí odkaz:
https://doaj.org/article/ac0ea87fcbd444e6a5571025f19f94b5
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100521- (2021)
Summary: CRISPR interference is an increasingly popular method for perturbing gene expression. Guided by single-guide RNAs (sgRNAs), nuclease-deficient Cas9 proteins bind to specific DNA sequences and hinder transcription. Specificity is achieved thr
Externí odkaz:
https://doaj.org/article/59c63be3b5ae4335ae0d8a99663ae003
Publikováno v:
mBio, Vol 6, Iss 5 (2015)
ABSTRACT In all three domains of life, organisms use nonspecific DNA-binding proteins to compact and organize the genome as well as to regulate transcription on a global scale. Histone is the primary eukaryotic nucleoprotein, and its evolutionary roo
Externí odkaz:
https://doaj.org/article/a64e3a417e944118ad53da84cdff51ca
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135693 (2015)
Previous work demonstrated that the TrmB transcription factor is responsible for regulating the expression of many enzyme-coding genes in the hypersaline-adapted archaeon Halobacterium salinarum via a direct interaction with a cis-regulatory sequence
Externí odkaz:
https://doaj.org/article/0d37e12231a44117bb72a290a50a3bba
Autor:
Kristine Trotta, Beth M Hayes, Johannes P Schneider, Jing Wang, Horia Todor, Patrick Rockefeller Grimes, Ziyi Zhao, William Hatleberg, Melanie R Silvis, Rachel Kim, Byoung-Mo Koo, Marek Basler, Seemay Chou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca155bd523aebe5a72c8adfcd2311edc
https://doi.org/10.15252/rc.2023233252
https://doi.org/10.15252/rc.2023233252
Autor:
Kristine L Trotta, Beth M Hayes, Johannes P Schneider, Jing Wang, Horia Todor, Patrick Rockefeller Grimes, Ziyi Zhao, William L Hatleberg, Melanie R Silvis, Rachel Kim, Byoung Mo Koo, Marek Basler, Seemay Chou
Publikováno v:
bioRxiv
Gram-negative bacteria can antagonize neighboring microbes using a type VI secretion system (T6SS) to deliver toxins that target different essential cellular features. Despite the conserved nature of these targets, T6SS potency can vary across recipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f197346a4269ad069e18b14a70b9e6
https://europepmc.org/articles/PMC9900751/
https://europepmc.org/articles/PMC9900751/
Autor:
Parth Kumar, Carol A. Gross, Hendrik Osadnik, Spencer Cesar, Melanie R. Silvis, Kerwyn Casey Huang, Cameron C. Hearne, Handuo Shi, Horia Todor, Jason M. Peters, Andrew N. Gray, Manohary Rajendram
Publikováno v:
mBio
mBio, Vol 12, Iss 5 (2021)
mBio, Vol 12, Iss 5 (2021)
CRISPR interference (CRISPRi) has facilitated the study of essential genes in diverse organisms using both high-throughput and targeted approaches. Despite the promise of this technique, no comprehensive arrayed CRISPRi library targeting essential ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7411aca698d520e96b5ae041d7d83f
https://pubmed.ncbi.nlm.nih.gov/34634934
https://pubmed.ncbi.nlm.nih.gov/34634934