Conditional Deletion of Sost in MSC-Derived Lineages Identifies Specific Cell-Type Contributions to Bone Mass and B-Cell Development

Autor: Yee, CS, Manilay, JO, Chang, JC, Hum, NR, Murugesh, DK, Bajwa, J, Mendez, ME, Economides, AE, Horan, DJ, Robling, AG, Loots, GG

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol 33, iss 10
Yee, CS; Manilay, JO; Chang, JC; Hum, NR; Murugesh, DK; Bajwa, J; et al.(2018). Conditional Deletion of Sost in MSC-Derived Lineages Identifies Specific Cell-Type Contributions to Bone Mass and B-Cell Development. JOURNAL OF BONE AND MINERAL RESEARCH, 33(10), 1748-1759. doi: 10.1002/jbmr.3467. UC Merced: Retrieved from: http://www.escholarship.org/uc/item/3c4679hb

Sclerostin (Sost) is a negative regulator of bone formation and blocking its function via antibodies has shown great therapeutic promise by increasing both bone mass in humans and animal models. Sclerostin deletion in Sost KO mice (Sost-/- ) causes h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::48e51533f2503376d277e641078b2832
https://escholarship.org/uc/item/3c4679hb

Letter: The Karen Ann Quilan case

Autor: Horan Dj

Publikováno v: JAMA: The Journal of the American Medical Association. 235:1839-1840

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13236b5d8dd31e9716205d62e3e43a7
https://doi.org/10.1001/jama.235.17.1839

Targeted inhibition of Wnt signaling with a Clostridioides difficile toxin B fragment suppresses breast cancer tumor growth.

Autor: He A; Department of Oncology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China.; Department of Urology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America., Tian S; Department of Urology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America.; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing, People's Republic of China., Kopper O; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands., Horan DJ; Department of Anatomy & Cell Biology, Indiana University School of Medicine, Barnhill, Indianapolis, United States of America., Chen P; Department of Physiology and Biophysics, University of California, Irvine, California, United States of America., Bronson RT; Rodent Histopathology, Harvard Medical School, Boston, Massachusetts, United States of America., Sheng R; Kirby Neurobiology Center, Boston Children's Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States of America., Wu H; Department of Vascular Biology, Boston Children's Hospital, Boston, Massachusetts, United States of America., Sui L; Department of Vascular Biology, Boston Children's Hospital, Boston, Massachusetts, United States of America., Zhou K; Department of Vascular Biology, Boston Children's Hospital, Boston, Massachusetts, United States of America., Tao L; Department of Urology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America., Wu Q; Department of Urology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America.; Central Laboratory of Medical Research Centre, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People's Republic of China., Huang Y; Department of Oncology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China., Shen Z; Department of Oncology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China., Han S; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America., Chen X; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America., Chen H; Department of Vascular Biology, Boston Children's Hospital, Boston, Massachusetts, United States of America., He X; Kirby Neurobiology Center, Boston Children's Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States of America., Robling AG; Department of Anatomy & Cell Biology, Indiana University School of Medicine, Barnhill, Indianapolis, United States of America., Jin R; Department of Physiology and Biophysics, University of California, Irvine, California, United States of America., Clevers H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands., Xiang D; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.; Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China., Li Z; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America., Dong M; Department of Urology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America.

Publikováno v: PLoS biology [PLoS Biol] 2023 Nov 09; Vol. 21 (11), pp. e3002353. Date of Electronic Publication: 2023 Nov 09 (Print Publication: 2023).

Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation.

Autor: Atkinson EG; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA., Adaway M; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA., Horan DJ; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA.; Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA., Korff C; Department of Medical and Molecular Genetics, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA., Klunk A; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA., Orr AL; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA., Ratz K; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA., Bellido T; Department of Physiology and Cell BiologyUniversity of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.; Central Arkansas Veterans Healthcare System, Little Rock, AR, USA., Plotkin LI; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA.; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA., Robling AG; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA.; Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA.; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA., Bidwell JP; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA.; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA.

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2023 Jan; Vol. 38 (1), pp. 70-85. Date of Electronic Publication: 2022 Nov 22.

Exogenous Oncostatin M induces Cardiac Dysfunction, Musculoskeletal Atrophy, and Fibrosis.

Autor: Jengelley DHA; Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA., Wang M; Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA., Narasimhan A; Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA., Rupert JE; Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA., Young AR; Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Zhong X; Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA; Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA., Horan DJ; Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA., Robling AG; Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA., Koniaris LG; Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA; Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA., Zimmers TA; Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Otolaryngology, Head & Neck Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA; Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA. Electronic address: zimmerst@iu.edu.

Publikováno v: Cytokine [Cytokine] 2022 Nov; Vol. 159, pp. 155972. Date of Electronic Publication: 2022 Aug 30.