Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Horacio Cardenas"'
Autor:
Yinu Wang, Andrea E. Calvert, Horacio Cardenas, Jonathon S. Rink, Dominik Nahotko, Wenan Qiang, C. Estelle Ndukwe, Fukai Chen, Russell Keathley, Yaqi Zhang, Ji‐Xin Cheng, C. Shad Thaxton, Daniela Matei
Publikováno v:
Advanced Science, Vol 11, Iss 13, Pp n/a-n/a (2024)
Abstract Platinum (Pt)‐based chemotherapy is the main treatment for ovarian cancer (OC); however, most patients develop Pt resistance (Pt‐R). This work shows that Pt‐R OC cells increase intracellular cholesterol through uptake via the HDL recep
Externí odkaz:
https://doaj.org/article/c74208f5f91d408dacb341f964db8aef
Autor:
Andres Valdivia, Matthew Cowan, Horacio Cardenas, Ana Maria Isac, Guangyuan Zhao, Hao Huang, Daniela Matei
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundTumor heterogeneity is one of the key factors leading to chemo-resistance relapse. It remains unknown how resistant cancer cells influence sensitive cells during cohabitation and growth within a heterogenous tumors. The goal of our study wa
Externí odkaz:
https://doaj.org/article/275531b5e18f4a0e9c745260f68e548e
Autor:
Yuying Tan, Junjie Li, Guangyuan Zhao, Kai-Chih Huang, Horacio Cardenas, Yinu Wang, Daniela Matei, Ji-Xin Cheng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Metabolic reprogramming is associated with cancer initiation, progression and resistance to therapy. Here, the authors show that metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation is associated with cancer-cell platinum-b
Externí odkaz:
https://doaj.org/article/65e7d80db4764219a65df7b321e8f777
Autor:
Horacio Cardenas, Fang Fang, Guanglong Jiang, Susan M. Perkins, Chi Zhang, Robert E. Emerson, George Hutchins, Harold N. Keer, Yunlong Liu, Daniela Matei, Kenneth Nephew
Publikováno v:
Epigenetics, Vol 16, Iss 11, Pp 1201-1216 (2021)
High-grade serous ovarian cancer (HGSOC) harbours aberrant epigenetic features, including DNA methylation. In this study we delineate pathways and networks altered by DNA methylation and associated with HGSOC initiation and progression to a platinum-
Externí odkaz:
https://doaj.org/article/ae8d07e5d9604a41bb9960295ddd78e5
Autor:
Siqi Chen, Ping Xie, Matthew Cowan, Hao Huang, Horacio Cardenas, Russell Keathley, Edward J. Tanner, Gini F. Fleming, John W. Moroney, Alok Pant, Azza M. Akasha, Ramana V. Davuluri, Masha Kocherginsky, Bin Zhang, Daniela Matei
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 14 (2022)
Background Immune checkpoint inhibitors (ICIs) have modest activity in ovarian cancer (OC). To augment their activity, we used priming with the hypomethylating agent guadecitabine in a phase II study.Methods Eligible patients had platinum-resistant O
Externí odkaz:
https://doaj.org/article/77c5d430f0694e0b833523dcc364ac59
Autor:
Bin Zhang, Hao Huang, Cristina Ivan, Siqi Chen, Livia Elena Sima, Horacio Cardenas, Guangyuan Zhao, Yinu Wang, Daniela Matei
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/9953516a4dce45178c778aa3b3cc2cfa
Autor:
Jiyoon Lee, Bakhtiyor Yakubov, Cristina Ivan, David R. Jones, Andrea Caperell-Grant, Melissa Fishel, Horacio Cardenas, Daniela Matei
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 11, Pp 689-698 (2016)
Resistance to chemotherapy is a hallmark of pancreatic ductal adenocarcinoma (PDA) and has been partly attributed to the dense desmoplastic stroma, which forms a protective niche for cancer cells. Tissue transglutaminase (TG2), a Ca2+-dependent enzym
Externí odkaz:
https://doaj.org/article/ddfa8102ae784a41b77ad599e164f02b
Autor:
Horacio Cardenas Zardoni
Publikováno v:
Biblios, Vol 0, Iss 54, Pp 88-94 (2015)
Information policies do not occur in the abstract, as part of a theory or science of information, they do not exist in isolation, isolated from the organized action of society as a whole. While the productive sector may have a clear perspective of wh
Externí odkaz:
https://doaj.org/article/e401ed6a5e754003a4229abc5f927958
Autor:
Horacio Cardenas, Daniel Arango, Courtney Nicholas, Silvia Duarte, Gerard J. Nuovo, Wei He, Oliver H. Voss, M. Elba Gonzalez-Mejia, Denis C. Guttridge, Erich Grotewold, Andrea I. Doseff
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 3, p 323 (2016)
The increasing prevalence of inflammatory diseases and the adverse effects associated with the long-term use of current anti-inflammatory therapies prompt the identification of alternative approaches to reestablish immune balance. Apigenin, an abunda
Externí odkaz:
https://doaj.org/article/733bf280c3e54bfb909d86bd7cea9192
Autor:
Hao Huang, Guangyuan Zhao, Horacio Cardenas, Andres Felipe Valdivia, Yinu Wang, Daniela Matei
Publikováno v:
Molecular Cancer Therapeutics. 22:393-405
Development of resistance to platinum (Pt) in ovarian cancer remains a major clinical challenge. Here we focused on identifying epitranscriptomic modifications linked to Pt resistance. Fat mass and obesity-associated protein (FTO) is a N6-methyladeno