Serotonin transporter deficiency drives estrogen-dependent obesity and glucose intolerance

Autor: Joanne Wang, Mary F. Hebert, Weibin Zha, Tao Hu, Horace T. B. Ho

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)

Depression and use of antidepressant medications are both associated with increased risk of obesity, potentially attributed to a reduced serotonin transporter (SERT) function. However, how SERT deficiency promotes obesity is unknown. Here, we demonst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943549e7f8421a255e8ad866aea66809
https://doi.org/10.1038/s41598-017-01291-5

Residue Ile89 in human plasma membrane monoamine transporter influences its organic cation transport activity and sensitivity to inhibition by dilazep

Autor: Joanne Wang, Li Xia, Horace T. B. Ho

Publikováno v: Biochemical Pharmacology. 84:383-390

Plasma membrane monoamine transporter (PMAT) is a polyspecific organic cation transporter belonging to the equilibrative nucleoside transporter (ENT) family. Despite its distinct substrate specificity from the classic nucleoside transporters ENT1 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972682790d29298cd36692eaced864ce
https://doi.org/10.1016/j.bcp.2012.04.018

Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated–dependent and –independent mechanisms

Autor: Wai Yi, Siu, Anita, Lau, Talha, Arooz, Jeremy P H, Chow, Horace T B, Ho, Randy Y C, Poon

Publikováno v: Molecular Cancer Therapeutics. 3:621-632

Camptothecin and Adriamycin are clinically important inhibitors for topoisomerase (Topo) I and Topo II, respectively. The ataxia-telangiectasia mutated (ATM) product is essential for ionizing radiation-induced DNA damage responses, but the role of AT

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https://doi.org/10.1158/1535-7163.621.3.5

Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene

Autor: Dea Adamsen, Paule Philippe, David Meili, Rémy Bruggmann, Susanne Walitza, Corinne Britschgi, Véronique Rüfenacht, Horace T. B. Ho, Beat Thöny, Joanne Wang, Elise Bobrowski, Lionel Van Maldergem, Vincent Ramaekers, Caroline Nava, Edna Grünblatt

Publikováno v: Molecular Autism
Molecular autism, 5
Adamsen, Dea; Ramaekers, Vincent; Ho, Horace Tb; Britschgi, Corinne; Rüfenacht, Véronique; Meili, David; Bobrowski, Elise; Philippe, Paule; Nava, Caroline; Van Maldergem, Lionel; Bruggmann, Rémy; Walitza, Susanne; Wang, Joanne; Grünblatt, Edna; Thöny, Beat (2014). Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene. Molecular autism, 5(43), p. 43. BioMed Central 10.1186/2040-2392-5-43

Background Patients with autism spectrum disorder (ASD) may have low brain serotonin concentrations as reflected by the serotonin end-metabolite 5-hydroxyindolacetic acid (5HIAA) in cerebrospinal fluid (CSF). Methods We sequenced the candidate genes

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https://www.zora.uzh.ch/id/eprint/98675/

Electrophysiological characterization of the polyspecific organic cation transporter plasma membrane monoamine transporter

Autor: Ellappan Babu, Mingyan Zhou, Horace T. B. Ho, Vadivel Ganapathy, Shiro Itagaki, Joanne Wang

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 40(6)

Plasma membrane monoamine transporter (PMAT) is a polyspecific organic cation (OC) transporter that transports a variety of endogenous biogenic amines and xenobiotic cations. Previous radiotracer uptake studies showed that PMAT-mediated OC transport

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9478f2e04e473063a76a2e6f349a7913
https://pubmed.ncbi.nlm.nih.gov/22396231