Zobrazeno 1 - 10
of 535
pro vyhledávání: '"Horace H Loh"'
Autor:
Lei Zhang, Cherkaouia Kibaly, Yu‐Jun Wang, Chi Xu, Kyu Young Song, Patrick W McGarrah, Horace H Loh, Jing‐Gen Liu, Ping‐Yee Law
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 11, Pp 1521-1536 (2017)
Abstract Opiate withdrawal/negative reinforcement has been implicated as one of the mechanisms for the progression from impulsive to compulsive drug use. Increase in the intracellular cAMP level and protein kinase A (PKA) activities within the neuroc
Externí odkaz:
https://doaj.org/article/9497773952d5463cb90d28ececad52aa
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153628 (2016)
The regulation of adult neurogenesis by opiates has been implicated in modulating different addiction cycles. At which neurogenesis stage opiates exert their action remains unresolved. We attempt to define the temporal window of morphine's inhibition
Externí odkaz:
https://doaj.org/article/4bb56e692f7e49969c3194553de62078
Publikováno v:
Frontiers in Genetics, Vol 3 (2012)
Non-coding RNAs, especially micro-RNAs (miRNAs) have been reported to be involved in a variety of biological processes, including several related to the addictive drugs. The biological functions of opioids, one typical type of addictive drugs, have a
Externí odkaz:
https://doaj.org/article/869fd3968ab94f17aa3499c75a8e4eef
Autor:
Ru Liu, Yue Xing, Herui Zhang, Junling Wang, Huanling Lai, Lipeng Cheng, Donghong Li, Tao Yu, Xiaoming Yan, Cuiping Xu, Yueshan Piao, Linghui Zeng, Horace H. Loh, Guojun Zhang, Xiaofeng Yang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
ObjectiveAltered expression patterns of Na+-K+-2Cl– (NKCC1) and K+-Cl– (KCC2) co-transporters have been implicated in the pathogenesis of epilepsy. Here, we assessed the effects of imbalanced NKCC1 and KCC2 on γ-aminobutyric acidergic (GABAergic
Externí odkaz:
https://doaj.org/article/3aca929bbb684b5696f68622c98802d1
Publikováno v:
Cell Regeneration, Vol 10, Iss 1, Pp 1-12 (2021)
Abstract Background Epigenetic modifications, namely non-coding RNAs, DNA methylation, and histone modifications such as methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation play a significant role in brain development. DNA meth
Externí odkaz:
https://doaj.org/article/3905335db51a42579615401574ef710a
Autor:
Junling Wang, Bin Jing, Ru Liu, Donghong Li, Wei Wang, Jiaoyang Wang, Jianfeng Lei, Yue Xing, Jiaqing Yan, Horace H. Loh, Guangming Lu, Xiaofeng Yang
Publikováno v:
NeuroImage, Vol 237, Iss , Pp 118133- (2021)
Accurate epileptogenic zone (EZ) or seizure onset zone (SOZ) localization is crucial for epilepsy surgery optimization. Previous animal and human studies on epilepsy have reported that changes in blood oxygen level-dependent (BOLD) signals induced by
Externí odkaz:
https://doaj.org/article/fe0caa87b743468bad55657cea96ce86
Autor:
Xiaonan Li, Tao Yu, Zhiwei Ren, Xueyuan Wang, Jiaqing Yan, Xin Chen, Xiaoming Yan, Wei Wang, Yue Xing, Xianchang Zhang, Herui Zhang, Horace H. Loh, Guojun Zhang, Xiaofeng Yang
Publikováno v:
Frontiers in Human Neuroscience, Vol 15 (2021)
Accurate localization of the epileptogenic zone (EZ) is a key factor to obtain good surgical outcome for refractory epilepsy patients. However, no technique, so far, can precisely locate the EZ, and there are barely any reports on the combined applic
Externí odkaz:
https://doaj.org/article/2c07807258c94b7e9797e83ee723bac4
Autor:
Lining Liang, Jinlong Chen, Yuan Li, Xiaowei Lai, Hao Sun, Changpeng Li, Mengdan Zhang, Tingting Yang, Fei Meng, Ping-Yee Law, Horace H. Loh, Hui Zheng
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3625-3631.e6 (2020)
Summary: Normally, opioids function in a receptor-dependent manner. They bind to opioid receptors, activate or inhibit receptor activation, and subsequently modulate downstream signal transduction. However, the complex functions of opioids and the lo
Externí odkaz:
https://doaj.org/article/6536df257aa64bafb263e3ca5dd852f4
Autor:
Ramajayam Kuppusamy, Ying-Ting Hsu, Yi-Yu Ke, Po-Wei Chang, Yung-Chiao Chang, Hsiao-Fu Chang, Pei-Chen Wang, Yu-Hao Lin, Yu-Chen Huang, Teng-Kuang Yeh, Jian-Ying Chuang, Horace H. Loh, Chuan Shih, Chiung-Tong Chen, Shiu-Hwa Yeh, Shau-Hua Ueng
Publikováno v:
European journal of medicinal chemistry. 243
Currently, there is a significant unmet need for novel analgesics with fewer side effects. In this study, we carried out structural modification of a hit compound previously identified in an artificial-intelligence (AI) virtual screening and discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ee9905775805f6c25c794ef27127b7
https://pubmed.ncbi.nlm.nih.gov/36084534
https://pubmed.ncbi.nlm.nih.gov/36084534
Publikováno v:
The Scientific World Journal, Vol 2016 (2016)
During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor c
Externí odkaz:
https://doaj.org/article/6b82881c9c6b45189db6a35020aaea0c