Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis.

Autor: Ungricht R; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Guibbal L; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Lasbennes MC; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Orsini V; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Beibel M; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Waldt A; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Cuttat R; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Carbone W; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Basler A; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Roma G; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Nigsch F; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Tchorz JS; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Hoepfner D; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Hoppe PS; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland. Electronic address: philipp.hoppe@novartis.com.

Publikováno v: Cell stem cell [Cell Stem Cell] 2022 Jan 06; Vol. 29 (1), pp. 160-175.e7. Date of Electronic Publication: 2021 Nov 29.

The tumor suppressor WT1 drives progenitor cell progression and epithelialization to prevent Wilms tumorigenesis in human kidney organoids.

Autor: Waehle V; Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland; Faculty of Sciences, University of Basel, 4003 Basel, Switzerland., Ungricht R; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Hoppe PS; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Betschinger J; Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland. Electronic address: joerg.betschinger@fmi.ch.

Publikováno v: Stem cell reports [Stem Cell Reports] 2021 Sep 14; Vol. 16 (9), pp. 2107-2117. Date of Electronic Publication: 2021 Aug 26.

Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.

Autor: Altamura S; Department of Pediatric Hematology, Oncology and Immunology - University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit, Heidelberg, Germany., Vegi NM; Institute of Experimental Cancer Research, Universitätsklinikum Ulm, Ulm, Germany., Hoppe PS; Department of Biosystems Bioscience and Engineering, ETH Zürich, Basel, Switzerland., Schroeder T; Department of Biosystems Bioscience and Engineering, ETH Zürich, Basel, Switzerland., Aichler M; Research Unit Analytical Pathology, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany., Walch A; Research Unit Analytical Pathology, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany., Okreglicka K; Institute of Molecular Health Sciences, ETH Zurich, Zürich, Switzerland., Hültner L; Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), München, Germany., Schneider M; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, München, Germany., Ladinig C; Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), München, Germany., Kuklik-Roos C; Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), München, Germany., Mysliwietz J; Institute of Molecular Immunology, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), München, Germany., Janik D; Research Unit Analytical Pathology, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany., Neff F; Research Unit Analytical Pathology, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany., Rathkolb B; Institute of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Genzentum, München, Germany.; Institute of Experimental Genetics, Geman Mouse Clinic (GMC), Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., de Angelis MTH; Institute of Experimental Genetics, Geman Mouse Clinic (GMC), Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Chair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Freising, Germany., Buske C; Institute of Experimental Cancer Research, Universitätsklinikum Ulm, Ulm, Germany., Silva ARD; Department of Pediatric Hematology, Oncology and Immunology - University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit, Heidelberg, Germany., Muedder K; Department of Pediatric Hematology, Oncology and Immunology - University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit, Heidelberg, Germany., Conrad M; Institute of Developmental Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany., Ganz T; Departments of Medicine and Pathology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Kopf M; Institute of Molecular Health Sciences, ETH Zurich, Zürich, Switzerland., Muckenthaler MU; Department of Pediatric Hematology, Oncology and Immunology - University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit, Heidelberg, Germany., Bornkamm GW; Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), München, Germany georg.bornkamm@t-online.de.

Publikováno v: Haematologica [Haematologica] 2020 Apr; Vol. 105 (4), pp. 937-950. Date of Electronic Publication: 2019 Jun 27.

Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells.

Autor: Loeffler D; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; Research Unit Stem Cell Dynamics, Helmholtz Center Munich - German Research Center for Environmental Health, Neuherberg, Germany., Wehling A; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Schneiter F; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Zhang Y; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Müller-Bötticher N; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Hoppe PS; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; Research Unit Stem Cell Dynamics, Helmholtz Center Munich - German Research Center for Environmental Health, Neuherberg, Germany., Hilsenbeck O; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; Research Unit Stem Cell Dynamics, Helmholtz Center Munich - German Research Center for Environmental Health, Neuherberg, Germany., Kokkaliaris KD; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; Research Unit Stem Cell Dynamics, Helmholtz Center Munich - German Research Center for Environmental Health, Neuherberg, Germany., Endele M; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; Research Unit Stem Cell Dynamics, Helmholtz Center Munich - German Research Center for Environmental Health, Neuherberg, Germany., Schroeder T; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland. timm.schroeder@bsse.ethz.ch.; Research Unit Stem Cell Dynamics, Helmholtz Center Munich - German Research Center for Environmental Health, Neuherberg, Germany. timm.schroeder@bsse.ethz.ch.

Publikováno v: Nature [Nature] 2019 Sep; Vol. 573 (7774), pp. 426-429. Date of Electronic Publication: 2019 Sep 04.

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury.

Autor: Planas-Paz L; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Sun T; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Pikiolek M; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Cochran NR; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA., Bergling S; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Orsini V; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Yang Z; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA., Sigoillot F; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA., Jetzer J; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Syed M; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Neri M; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Schuierer S; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Morelli L; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Hoppe PS; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Schwarzer W; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Cobos CM; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland; Hospital Aleman, Buenos Aires, Argentina., Alford JL; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA., Zhang L; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA., Cuttat R; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Waldt A; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Carballido-Perrig N; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Nigsch F; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Kinzel B; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Nicholson TB; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA., Yang Y; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA., Mao X; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA., Terracciano LM; Institute for Pathology, University Hospital Basel, Basel, Switzerland., Russ C; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA., Reece-Hoyes JS; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA., Gubser Keller C; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Sailer AW; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Bouwmeester T; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Greenbaum LE; Novartis Institutes for Biomedical Research, Novartis Pharma AG, East Hanover, NJ, USA., Lugus JJ; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA., Cong F; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA., McAllister G; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA., Hoffman GR; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA., Roma G; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Tchorz JS; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland. Electronic address: jan.tchorz@novartis.com.

Publikováno v: Cell stem cell [Cell Stem Cell] 2019 Jul 03; Vol. 25 (1), pp. 39-53.e10. Date of Electronic Publication: 2019 May 09.