A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity.

Autor: Boeszoermenyi A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Bernaleau L; Department of Immunobiology, University of Lausanne, Epalinges, Switzerland., Chen X; Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China., Kartnig F; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Xie M; Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China., Zhang H; Department of Immunobiology, University of Lausanne, Epalinges, Switzerland., Zhang S; Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China., Delacrétaz M; Department of Immunobiology, University of Lausanne, Epalinges, Switzerland., Koren A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Hopp AK; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Dvorak V; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Kubicek S; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Aletaha D; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Yang M; Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.; Cryo-EM Facility Center, Southern University of Science & Technology, Shenzhen, Guangdong, China., Rebsamen M; Department of Immunobiology, University of Lausanne, Epalinges, Switzerland. manuele.rebsamen@unil.ch., Heinz LX; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. leonhard.heinz@meduniwien.ac.at., Superti-Furga G; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. gsuperti@cemm.oeaw.ac.at.; Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria. gsuperti@cemm.oeaw.ac.at.

Publikováno v: Nature communications [Nat Commun] 2023 Oct 20; Vol. 14 (1), pp. 6626. Date of Electronic Publication: 2023 Oct 20.

MyoD induces ARTD1 and nucleoplasmic poly-ADP-ribosylation during fibroblast to myoblast transdifferentiation.

Autor: Bisceglie L; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.; Molecular Life Science PhD Program of the Life Science Zurich Graduate School, University of Zurich, Zurich, Switzerland., Hopp AK; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland., Gunasekera K; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland., Wright RH; Centre de Regulació Genomica (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain.; Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya (UIC), 08003 Barcelona, Spain., Le Dily F; Centre de Regulació Genomica (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain., Vidal E; Centre de Regulació Genomica (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain., Dall'Agnese A; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Caputo L; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Nicoletti C; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Puri PL; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Beato M; Centre de Regulació Genomica (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Hottiger MO; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.

Publikováno v: IScience [iScience] 2021 Apr 17; Vol. 24 (5), pp. 102432. Date of Electronic Publication: 2021 Apr 17 (Print Publication: 2021).

Mitochondrial NAD ⁺ Controls Nuclear ARTD1-Induced ADP-Ribosylation.

Autor: Hopp AK; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland; Life Science Zurich Graduate School, Molecular Life Science Ph.D. Program, University of Zurich, 8057 Zurich, Switzerland., Teloni F; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland; Life Science Zurich Graduate School, Molecular Life Science Ph.D. Program, University of Zurich, 8057 Zurich, Switzerland., Bisceglie L; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland; Life Science Zurich Graduate School, Molecular Life Science Ph.D. Program, University of Zurich, 8057 Zurich, Switzerland., Gondrand C; Department of Chemical Biology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany., Raith F; Department of Chemical Biology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany; Faculty of Chemistry and Earth Sciences, University of Heidelberg, 69120 Heidelberg, Germany., Nowak K; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland; Life Science Zurich Graduate School, Molecular Life Science Ph.D. Program, University of Zurich, 8057 Zurich, Switzerland., Muskalla L; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland; Life Science Zurich Graduate School, Cancer Biology Ph.D. Program, University of Zurich, 8057 Zurich., Howald A; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland., Pedrioli PGA; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland; PHRT-CPAC, ETH Zurich, 8093 Zurich, Switzerland., Johnsson K; Department of Chemical Biology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany., Altmeyer M; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland., Pedrioli DML; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland., Hottiger MO; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland. Electronic address: michael.hottiger@dmmd.uzh.ch.

Publikováno v: Molecular cell [Mol Cell] 2021 Jan 21; Vol. 81 (2), pp. 340-354.e5. Date of Electronic Publication: 2021 Jan 14.

A Type I-F Anti-CRISPR Protein Inhibits the CRISPR-Cas Surveillance Complex by ADP-Ribosylation.

Autor: Niu Y; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China., Yang L; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China., Gao T; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China., Dong C; Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Liaoning Province, Shenyang 110866, China., Zhang B; Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China., Yin P; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China., Hopp AK; Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland., Li D; The Protein Preparation and Characterization Core Facility of Tsinghua University, The China National Center for Protein Sciences (Beijing) Tsinghua University Branch, Beijing 100084, China., Gan R; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China., Wang H; Department of Microbiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China., Liu X; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China., Cao X; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China., Xie Y; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China., Meng X; MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China., Deng H; MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China., Zhang X; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, 38 Xueyuan Road, Beijing 100191, China., Ren J; State Key Laboratory for Biology of Plant Diseases and Insect Pests/Key Laboratory of Control of Biological Hazard Factors (Plant Origin) for Agri-product Quality and Safety, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100081, China., Hottiger MO; Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland., Chen Z; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China; Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Liaoning Province, Shenyang 110866, China. Electronic address: zeliangchen@yahoo.com., Zhang Y; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address: zhangyishirly@hotmail.com., Liu X; Department of Microbiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. Electronic address: xiaoyun.liu@bjmu.edu.cn., Feng Y; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address: fengyue@mail.buct.edu.cn.

Publikováno v: Molecular cell [Mol Cell] 2020 Nov 05; Vol. 80 (3), pp. 512-524.e5. Date of Electronic Publication: 2020 Oct 12.

Regulation of Glucose Metabolism by NAD ⁺ and ADP-Ribosylation.

Autor: Hopp AK; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, CH-8057 Zurich, Switzerland.; Molecular Life Science Ph.D. Program, Life Science Zurich Graduate School, CH-8057 Zurich, Switzerland., Grüter P; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, CH-8057 Zurich, Switzerland., Hottiger MO; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, CH-8057 Zurich, Switzerland. michael.hottiger@dmmd.uzh.ch.

Publikováno v: Cells [Cells] 2019 Aug 13; Vol. 8 (8). Date of Electronic Publication: 2019 Aug 13.