Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Hopkinson RJ"'
Publikováno v:
Communications Chemistry. 6
Formaldehyde (HCHO) is a potent electrophile that is toxic above threshold levels, but which is also produced in the nuclei of eukaryotic cells by demethylases. We report studies with the four canonical human histones revealing that histone H2B react
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
While the oxygen-dependent reversal of lysine N(ɛ)-methylation is well established, the existence of bona fide N(ω)-methylarginine demethylases (RDMs) is controversial. Lysine demethylation, as catalysed by two families of lysine demethylases (the
Autor:
Donatella Labella, Lucia Altucci, Anthony Tumber, Biagina Marrocco, Clarence Yapp, Giuseppe Ciossani, Dante Rotili, Oliver N. King, Marcello Tortorici, Sergio Valente, Richard J. Hopkinson, Stefano Tomassi, Mariarosaria Conte, Andrea Mattevi, Akane Kawamura, Ettore Novellino, Rosaria Benedetti, Antonello Mai, Christopher J. Schofield
Publikováno v:
Journal of Medicinal Chemistry; Vol 57
Journal of Medicinal Chemistry
Journal of medicinal chemistry 57 (2014): 42–55. doi:10.1021/jm4012802
info:cnr-pdr/source/autori:Rotili, Dante; Tomassi, Stefano; Conte, Mariarosaria; Benedetti, Rosaria; Tortorici, Marcello; Ciossani, Giuseppe; Valente, Sergio; Marrocco, Biagina; Labella, Donatella; Novellino, Ettore; Mattevi, Andrea; Altucci, Lucia; Tumber, Anthony; Yapp, Clarence; King, Oliver N. F.; Hopkinson, Richard J.; Kawamura, Akane; Schofield, Christopher J.; Mai, Antonello/titolo:Pan-Histone Demethylase Inhibitors Simultaneously Targeting Jumonji C and Lysine-Specific Demethylases Display High Anticancer Activities/doi:10.1021%2Fjm4012802/rivista:Journal of medicinal chemistry/anno:2014/pagina_da:42/pagina_a:55/intervallo_pagine:42–55/volume:57
Journal of Medicinal Chemistry
Journal of medicinal chemistry 57 (2014): 42–55. doi:10.1021/jm4012802
info:cnr-pdr/source/autori:Rotili, Dante; Tomassi, Stefano; Conte, Mariarosaria; Benedetti, Rosaria; Tortorici, Marcello; Ciossani, Giuseppe; Valente, Sergio; Marrocco, Biagina; Labella, Donatella; Novellino, Ettore; Mattevi, Andrea; Altucci, Lucia; Tumber, Anthony; Yapp, Clarence; King, Oliver N. F.; Hopkinson, Richard J.; Kawamura, Akane; Schofield, Christopher J.; Mai, Antonello/titolo:Pan-Histone Demethylase Inhibitors Simultaneously Targeting Jumonji C and Lysine-Specific Demethylases Display High Anticancer Activities/doi:10.1021%2Fjm4012802/rivista:Journal of medicinal chemistry/anno:2014/pagina_da:42/pagina_a:55/intervallo_pagine:42–55/volume:57
In prostate cancer, two different types of histone lysine demethylases (KDM), LSD1/KDM1 and JMJD2/KDM4, are co-expressed and co-localize with the androgen receptor. We designed and synthesized hybrid LSD1/JmjC - "pan-KDM" - inhibitors 1-6, by couplin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d1aef50dc49a0e68c8bb117a66e669
https://ora.ox.ac.uk/objects/uuid:bfd82582-e57e-451d-89ac-492128dcfdfb
https://ora.ox.ac.uk/objects/uuid:bfd82582-e57e-451d-89ac-492128dcfdfb
Autor:
Chothia SY; Leicester Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK., Emms VL; Leicester Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK., Thomas LA; Leicester Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK., Bulman NFA; Leicester Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK., Monks PS; Space Park Leicester, University of Leicester, 92 Corporation Road, Leicester, LE4 5SP, UK., Cordell RL; Space Park Leicester, University of Leicester, 92 Corporation Road, Leicester, LE4 5SP, UK. rc145@leicester.ac.uk., Hopkinson RJ; Leicester Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK. richard.hopkinson@leicester.ac.uk.
Publikováno v:
Scientific reports [Sci Rep] 2024 Sep 04; Vol. 14 (1), pp. 20621. Date of Electronic Publication: 2024 Sep 04.
Autor:
Emms VL; Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Leicester, UK., Chothia SY; Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Leicester, UK., Hopkinson RJ; Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Leicester, UK. richard.hopkinson@leicester.ac.uk.
Publikováno v:
Nature chemical biology [Nat Chem Biol] 2024 Mar; Vol. 20 (3), pp. 268-270.
Autor:
John T; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk., Saffoon N; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk., Walsby-Tickle J; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk., Hester SS; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford Oxford UK., Dingler FA; MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital/Headley Way Oxford OX3 9DS UK., Millington CL; MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital/Headley Way Oxford OX3 9DS UK., McCullagh JSO; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk., Patel KJ; MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital/Headley Way Oxford OX3 9DS UK., Hopkinson RJ; Leicester Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building Lancaster Road Leicester LE1 7RH UK richard.hopkinson@leicester.ac.uk., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk.
Publikováno v:
Chemical science [Chem Sci] 2024 Jan 15; Vol. 15 (7), pp. 2509-2517. Date of Electronic Publication: 2024 Jan 15 (Print Publication: 2024).
Autor:
Emms VL; Institute for Structural and Chemical Biology, School of Chemistry, University of Leicester Henry Wellcome Building Lancaster Road Leicester LE1 7RH UK richard.hopkinson@leicester.ac.uk., Lewis LA; Institute for Structural and Chemical Biology, School of Chemistry, University of Leicester Henry Wellcome Building Lancaster Road Leicester LE1 7RH UK richard.hopkinson@leicester.ac.uk., Beja L; Institute for Structural and Chemical Biology, School of Chemistry, University of Leicester Henry Wellcome Building Lancaster Road Leicester LE1 7RH UK richard.hopkinson@leicester.ac.uk., Bulman NFA; Institute for Structural and Chemical Biology, School of Chemistry, University of Leicester Henry Wellcome Building Lancaster Road Leicester LE1 7RH UK richard.hopkinson@leicester.ac.uk., Pires E; Department of Chemistry, University of Oxford, Chemistry Research Laboratory 12 Mansfield Road Oxford OX1 3TA UK., Muskett FW; Institute for Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester Henry Wellcome Building Lancaster Road Leicester LE1 7RH UK., McCullagh JSO; Department of Chemistry, University of Oxford, Chemistry Research Laboratory 12 Mansfield Road Oxford OX1 3TA UK., Swift LP; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital Headington Oxford OX3 9DS UK lonnie.swift@imm.ox.ac.uk peter.mchugh@imm.ox.ac.uk., McHugh PJ; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital Headington Oxford OX3 9DS UK lonnie.swift@imm.ox.ac.uk peter.mchugh@imm.ox.ac.uk., Hopkinson RJ; Institute for Structural and Chemical Biology, School of Chemistry, University of Leicester Henry Wellcome Building Lancaster Road Leicester LE1 7RH UK richard.hopkinson@leicester.ac.uk.
Publikováno v:
Chemical science [Chem Sci] 2023 Sep 15; Vol. 14 (44), pp. 12498-12505. Date of Electronic Publication: 2023 Sep 15 (Print Publication: 2023).
Autor:
Chothia SY; Leicester Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK., Carr M; Leicester Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK., Monks PS; Space Park Leicester, University of Leicester, 92 Corporation Road, Leicester, LE4 5SP, UK., Cordell RL; Space Park Leicester, University of Leicester, 92 Corporation Road, Leicester, LE4 5SP, UK., Hopkinson RJ; Leicester Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK. richard.hopkinson@leicester.ac.uk.
Publikováno v:
Scientific reports [Sci Rep] 2023 Sep 05; Vol. 13 (1), pp. 14642. Date of Electronic Publication: 2023 Sep 05.
Autor:
Saward BG; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK., Leissing TM; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK., Clifton IJ; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK., Tumber A; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK., Timperley CM; CBR Division, Defence Science and Technology Laboratory (DSTL), Porton Down, Salisbury, SP4 0JQ, UK., Hopkinson RJ; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK.; Present address: Leicester Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK., Schofield CJ; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK.
Publikováno v:
Chembiochem : a European journal of chemical biology [Chembiochem] 2023 Feb 14; Vol. 24 (4), pp. e202200576. Date of Electronic Publication: 2023 Jan 09.
Autor:
Chen X; Leicester Institute of Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK. richard.hopkinson@leicester.ac.uk., Chothia SY; Leicester Institute of Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK. richard.hopkinson@leicester.ac.uk., Basran J; Department of Molecular and Cell Biology, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK., Hopkinson RJ; Leicester Institute of Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK. richard.hopkinson@leicester.ac.uk.
Publikováno v:
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Jun 10; Vol. 57 (47), pp. 5778-5781.