Zobrazeno 1 - 10
of 404
pro vyhledávání: '"Hopkins, PM"'
Autor:
Clark, S, Thomas, C, Fallaha, D, Wilson, M, Hopkins, PM, Savic, S, Savic, L, Research and Audit Federation of Trainees (RAFT) group
Background We sought to define the prevalence and nature of patient-reported drug allergies, determine their impact on prescribing, and explore drug allergy knowledge and attitudes amongst anaesthetists. Methods We performed a prospective cross-secti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::d0d086d210c8f5be37e78e29efbd6036
Autor:
Lamboley, CR, Pearce, L, Seng, C, Meizoso-Huesca, A, Singh, DP, Frankish, BP, Kaura, V, Lo, HP, Ferguson, C, Allen, PD, Hopkins, PM, Parton, RG, Murphy, RM, van der Poel, C, Barclay, CJ, Launikonis, BS
Muscle contraction depends on tightly regulated Ca2+ release. Aberrant Ca2+ leak through ryanodine receptor 1 (RyR1) on the sarcoplasmic reticulum (SR) membrane can lead to heatstroke and malignant hyperthermia (MH) susceptibility, as well as severe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::bd71f794da65da938b5a6dfbae9e9b85
https://eprints.whiterose.ac.uk/179811/1/sciadv.abi7166.pdf
https://eprints.whiterose.ac.uk/179811/1/sciadv.abi7166.pdf
Background: Individuals genetically susceptible to malignant hyperthermia (MH) exhibit hypermetabolic reactions when exposed to volatile anaesthetics. Mitochondrial dysfunction has previously been associated with the MH-susceptible (MHS) phenotype in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::9e8d1b6e016e9bc621efd46c71f31a1f
This article reviews advancements in the genetics of malignant hyperthermia, new technologies and approaches for its diagnosis, and the existing limitations of genetic testing for malignant hyperthermia. It also reviews the various RYR1-related disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::021b0c3e23aca296d529dd11bbda5ec4
Next-generation Sequencing of RYR1 and CACNA1S in Malignant Hyperthermia and Exertional Heat Illness
Autor:
Fiszer, D, Shaw, MA, Fisher, NA, Carr, IM, Gupta, PK, Watkins, EJ, Roiz De Sa, D, Kim, JH, Hopkins, PM
Background: Variants in RYR1 are associated with the majority of cases of malignant hyperthermia (MH), a form of heat illness pharmacogenetically triggered by general anesthetics, and they have also been associated with exertional heat illness (EHI).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::5bfabb1ecc01b300f2665140eec666aa
https://eprints.whiterose.ac.uk/93119/1/thisone.pdf
https://eprints.whiterose.ac.uk/93119/1/thisone.pdf
Publikováno v:
Endocrine research. 22(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8021a68c8b6cbe9564fc5764f7d9fe0b
https://pubmed.ncbi.nlm.nih.gov/8969927
https://pubmed.ncbi.nlm.nih.gov/8969927
Autor:
Hopkins Pm
Publikováno v:
Intensive care medicine. 22(4)
To study the effect of human recombinant tumour necrosis factor alpha (TNF alpha) on contracture development and changes in the ionic composition of the external bathing solution of electrically stimulated rat hemidiaphragm preparations in vitro.A tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08192cd847556db130ef37eb277fb12
https://pubmed.ncbi.nlm.nih.gov/8708176
https://pubmed.ncbi.nlm.nih.gov/8708176
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