In vivo evolution of env in SHIV-AD8EO-infected rhesus macaques after AAV-vectored delivery of eCD4-Ig

Autor: O’Hagan, Daniel ¹, Shandilya, Siddhartha ¹, Hopkins, Lincoln J. ³, Hahn, Patricia A. ^{1, 2}, Fuchs, Sebastian P. ⁴, Martinez-Navio, José M. ⁴, Alpert, Michael D. ⁵, Gardner, Mathew R. ⁶, Desrosiers, Ronald C. ⁴, Gao, Guangping ⁷, Lifson, Jeffrey D. ⁸, Farzan, Michael ⁹, Ardeshir, Amir ¹⁰, Martins, Mauricio A. ^{1, ∗}

Publikováno v: In Molecular Therapy December 2024

In vivo evolution of env in SHIV-AD8 EO -infected rhesus macaques after AAV-vectored delivery of eCD4-Ig.

Autor: O'Hagan D; Department of Immunology and Microbiology, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458, USA., Shandilya S; Department of Immunology and Microbiology, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458, USA., Hopkins LJ; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA., Hahn PA; Department of Immunology and Microbiology, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458, USA; The Skaggs Graduate School, The Scripps Research Institute, Jupiter, FL 33458, USA., Fuchs SP; University of Miami, Miller School of Medicine, Miami, FL 33136, USA., Martinez-Navio JM; University of Miami, Miller School of Medicine, Miami, FL 33136, USA., Alpert MD; Emmune Inc., Juno Beach, FL 33408, USA., Gardner MR; Department of Medicine, Emory University, Atlanta, GA 30322, USA., Desrosiers RC; University of Miami, Miller School of Medicine, Miami, FL 33136, USA., Gao G; Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA 01605, USA., Lifson JD; AIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, MD 21702, USA., Farzan M; Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Ardeshir A; Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA., Martins MA; Department of Immunology and Microbiology, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458, USA. Electronic address: mauricio.martins@ufl.edu.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2024 Dec 12. Date of Electronic Publication: 2024 Dec 12.