Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Hopewell,JC"'
Autor:
Clarke, R, Von Ende, A, Schmidt, LE, Yin, X, Hill, M, Hughes, AD, Pechlaner, R, Willeit, J, Kiechl, S, Watkins, H, Theofilatos, K, Hopewell, JC, Mayr, M
Publikováno v:
Circulation Research. 132:452-464
Background: Recognition of the importance of conventional lipid measures and the advent of novel lipid-lowering medications have prompted the need for more comprehensive lipid panels to guide use of emerging treatments for the prevention of coronary
Background Inflammation has been implicated in the pathogenesis of coronary heart disease, but the relevance and independence of individual inflammatory proteins is uncertain. Objective To examine the relationships between a spectrum of inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b2bee21476124587aad97768b908cd
https://doi.org/10.1093/eurjpc/zwad020
https://doi.org/10.1093/eurjpc/zwad020
Autor:
Sammons, E, Hopewell, JC, Chen, F, Stevens, W, Wallendszus, K, Valdes-Marquez, E, Dayanandan, R, Knott, C, Murphy, K, Wincott, E, Baxter, A, Goodenough, R, Lay, M, Hill, M, Macdonnell, S, Fabbri, G, Lucci, D, Fajardo-Moser, M, Brenner, S, Hao, D, Zhang, H, Liu, J, Wuhan, B, Mosegaard, S, Herrington, W, Wanner, C, Angermann, C, Ertl, G, Maggioni, A, Barter, P, Mihaylova, B, Mitchel, Y, Blaustein, R, Goto, S, Tobert, J, DeLucca, P, Chen, Y, Chen, Z, Gray, A, Haynes, R, Armitage, J, Baigent, C, Wiviott, S, Cannon, C, Braunwald, E, Collins, R, Bowman, L, Landray, M
Aims REVEAL was the first randomized controlled trial to demonstrate that adding cholesteryl ester transfer protein inhibitor therapy to intensive statin therapy reduced the risk of major coronary events. We now report results from extended follow-up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01c272a367249a1e1ce5d7a3dbbc297
https://doi.org/10.1093/eurheartj/ehab863
https://doi.org/10.1093/eurheartj/ehab863
Autor:
Linden, AB, Clarke, R, Hammami, I, Hopewell, JC, Guo, Y, Whiteley, WN, Lin, K, Turnbull, I, Chen, Y, Yu, C, Lv, J, Offer, A, Bennett, D, Walters, RG, Li, L, Chen, Z, Parish, S
Publikováno v:
Linden, A B, Clarke, R, Hammami, I, Hopewell, J C, Guo, Y, Whiteley, W N, Lin, K, Turnbull, I, Chen, Y, Yu, C, Lv, J, Offer, A, Bennett, D, Walters, R G, Li, L, Chen, Z, Parish, S & Willey, J Z (ed.) 2022, ' Genetic associations of adult height with risk of cardioembolic and other subtypes of ischemic stroke : A mendelian randomization study in multiple ancestries ', PLoS Medicine, vol. 19, no. 4, e1003967 . https://doi.org/10.1371/journal.pmed.1003967
Background Taller adult height is associated with lower risks of ischemic heart disease in mendelian randomization (MR) studies, but little is known about the causal relevance of height for different subtypes of ischemic stroke. The present study exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd83ca190b46a3f6fa4efa077b460e92
https://doi.org/10.1371/journal.pmed.1003967
https://doi.org/10.1371/journal.pmed.1003967
Publikováno v:
In Value in Health December 2022 25(12) Supplement:S358-S358
Publikováno v:
Bioinformatics.
Motivation: Common small-effect genetic variants that contribute to human complex traits and disease are typically identified using traditional fixed-effect meta-analysis methods. However, the power to detect genetic associations under fixed-effect m
Autor:
Malik, R, Chauhan, G, Traylor, M, Sargurupremraj, M, Okada, Y, Mishra, A, Rutten-Jacobs, L, Giese, A-K, Van der Laan, SW, Gretarsdottir, S, Anderson, CD, Chong, M, Adams, HHH, Ago, T, Almgren, P, Amouyel, P, Ay, H, Bartz, TM, Benavente, OR, Bevan, S, Boncoraglio, GB, Brown, RD, Butterworth, AS, Carrera, C, Carty, CL, Chasman, DI, Chen, W-M, Cole, JW, Correa, A, Cotlarciuc, I, Cruchaga, C, Danesh, J, De Bakker, PIW, DeStefano, AL, Den Hoed, M, Duan, Q, Engelter, ST, Falcone, GJ, Gottesman, RF, Grewal, RP, Gudnason, V, Gustafsson, S, Haessler, J, Harris, TB, Hassan, A, Havulinna, AS, Heckbert, SR, Holliday, EG, Howard, G, Hsu, F-C, Hyacinth, IH, Ikram, MA, Ingelsson, E, Irvin, MR, Jian, X, Jimenez-Conde, J, Johnson, JA, Jukema, JW, Kanai, M, Keene, KL, Kissela, BM, Kleindorfer, DO, Kooperberg, C, Kubo, M, Lange, LA, Langefeld, CD, Langenberg, C, Launer, LJ, Lee, J-M, Lemmens, R, Leys, D, Lewis, CM, Lin, W-Y, Lindgren, AG, Lorentzen, E, Magnusson, PK, Maguire, J, Manichaikul, A, McArdle, PF, Meschia, JF, Mitchell, BD, Mosley, TH, Nalls, MA, Ninomiya, T, O'Donnell, MJ, Psaty, BM, Pulit, SL, Rannikmae, K, Reiner, AP, Rexrode, KM, Rice, K, Rich, SS, Ridker, PM, Rost, NS, Rothwell, PM, Rotter, JI, Rundek, T, Sacco, RL, Sakaue, S, Sale, MM, Salomaa, V, Sapkota, BR, Schmidt, R, Schmidt, CO, Schminke, U, Sharma, P, Slowik, A, Sudlow, CLM, Tanislav, C, Tatlisumak, T, Taylor, KD, Thijs, VNS, Thorleifsson, G, Thorsteinsdottir, U, Tiedt, S, Trompet, S, Tzourio, C, Van Duijn, CM, Walters, M, Wareham, NJ, Wassertheil-Smoller, S, Wilson, JG, Wiggins, KL, Yang, Q, Yusuf, S, Bis, JC, Pastinen, T, Ruusalepp, A, Schadt, EE, Koplev, S, Bjorkegren, JLM, Codoni, V, Civelek, M, Smith, NL, Tregouet, DA, Christophersen, IE, Roselli, C, Lubitz, SA, Ellinor, PT, Tai, ES, Kooner, JS, Kato, N, He, J, Van der Harst, P, Elliott, P, Chambers, JC, Takeuchi, F, Johnson, AD, Sanghera, DK, Melander, O, Jern, C, Strbian, D, Fernandez-Cadenas, I, Longstreth, WT, Rolfs, A, Hata, J, Woo, D, Rosand, J, Pare, G, Hopewell, JC, Saleheen, D, Stefansson, K, Worrall, BB, Kittner, SJ, Seshadri, S, Fornage, M, Markus, HS, Howson, JMM, Kamatani, Y, Debette, S, Dichgans, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::baa55c97f47572e79f07ce720e55419e
http://hdl.handle.net/10044/1/72119
http://hdl.handle.net/10044/1/72119
Autor:
Valdes-Marquez, E, Parish, S, Clarke, R, Stari, T, Worrall, BB, Hopewell, JC, Hofman, Bert, Ikram, Arfan, Chen, WM, Cheng, CY (Ching-Yu)
Publikováno v:
Neurology, 92(11), E1176-E1187. Lippincott Williams & Wilkins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::d136d7b9db692f59c332c92da9f95677
https://pure.eur.nl/en/publications/f5322613-2ba8-403b-a312-95f496a52cbe
https://pure.eur.nl/en/publications/f5322613-2ba8-403b-a312-95f496a52cbe
Autor:
Franceschini, N, Giambartolomei, C, de Vries, PS, Finan, C, Bis, JC, Huntley, RP, Lovering, RC, Tajuddin, SM, Winkler, TW, Graff, M, Kavousi, M, Dale, C, Smith, AV, Hofer, E, van Leeuwen, EM, Nolte, IM, Lu, L, Scholz, M, Sargurupremraj, M, Pitkänen, N, Franzén, O, Joshi, PK, Noordam, R, Marioni, RE, Hwang, SJ, Musani, SK, Schminke, U, Palmas, W, Isaacs, A, Correa, A, Zonderman, AB, Hofman, A, Teumer, A, Cox, AJ, Uitterlinden, AG, Wong, A, Smit, AJ, Newman, AB, Britton, A, Ruusalepp, A, Sennblad, B, Hedblad, B, Pasaniuc, B, Penninx, BW, Langefeld, CD, Wassel, CL, Tzourio, C, Fava, C, Baldassarre, D, O’Leary, DH, Teupser, D, Kuh, D, Tremoli, E, Mannarino, E, Grossi, E, Boerwinkle, E, Schadt, EE, Ingelsson, E, Veglia, F, Rivadeneira, F, Beutner, F, Chauhan, G, Heiss, G, Snieder, H, Campbell, H, Völzke, H, Markus, HS, Deary, IJ, Jukema, JW, de Graaf, J, Price, J, Pott, J, Hopewell, JC, Liang, J, Thiery, J, Engmann, J, Gertow, K, Rice, K, Taylor, KD, Dhana, K, Kiemeney, LALM, Lind, L, Raffield, LM, Launer, LJ, Holdt, LM, Dörr, M, Dichgans, M, Traylor, M, Sitzer, M, Kumari, M, Kivimaki, M, Nalls, MA, Melander, O, Raitakari, O, Franco, OH, Rueda-Ochoa, OL, Roussos, P, Whincup, PH, Amouyel, P, Giral, P
Publikováno v:
Nature communications, vol 9, iss 1
© 2018, The Author(s). Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cfd6957718ba704ea5a9b84901f5e110
https://escholarship.org/uc/item/7sw5z41s
https://escholarship.org/uc/item/7sw5z41s
Autor:
Hopewell, JC, Malik, R, Valdes-Marquez, E, Worrall, BB, Collins, R, METASTROKE Collaboration of the ISGC
Aims: PCSK9 genetic variants that have large effects on low density lipoprotein cholesterol (LDL-C) and coronary heart disease (CHD) have prompted the development of therapeutic PCSK9-inhibition. However, there is limited evidence that PCSK9 variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::169cd9d984c195d759d6e524b46c06b4
https://ora.ox.ac.uk/objects/uuid:441ba70e-e3af-4e22-af4f-2ecd0add4ee3
https://ora.ox.ac.uk/objects/uuid:441ba70e-e3af-4e22-af4f-2ecd0add4ee3