The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology

Autor: Ana Martinez Hernandez, Hendrik Urbanke, Alan L Gillman, Joon Lee, Sergey Ryazanov, Hope Y Agbemenyah, Eva Benito, Gaurav Jain, Lalit Kaurani, Gayane Grigorian, Andrei Leonov, Nasrollah Rezaei‐Ghaleh, Petra Wilken, Fernando Teran Arce, Jens Wagner, Martin Fuhrmann, Mario Caruana, Angelique Camilleri, Neville Vassallo, Markus Zweckstetter, Roland Benz, Armin Giese, Anja Schneider, Martin Korte, Ratnesh Lal, Christian Griesinger, Gregor Eichele, Andre Fischer

Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 1, Pp 32-47 (2017)

Abstract Alzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcrip

Externí odkaz: https://doaj.org/article/c508142ad7ed44dda436f67105c1fa85

Hypotensive and Antihypertensive Properties and Safety for Use of

Autor: Authentia, Sokpe, Merlin L K, Mensah, George A, Koffuor, Kwesi P, Thomford, Richmond, Arthur, Yakubu, Jibira, Michael K, Baah, Bright, Adedi, Hope Y, Agbemenyah

Publikováno v: Evidence-based Complementary and Alternative Medicine : eCAM

Introduction In the management of hypertension (a cardiovascular disease and the leading metabolic risk factor in noncommunicable diseases) with herbal medicines, efficacy and safety are of uttermost concern. This study sought to establish hypotensiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eef0335d034e3de956d0e7ad313e0e32
https://pubmed.ncbi.nlm.nih.gov/33488751

The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology

Autor: Roland Benz, Martin Fuhrman, Hope Y Agbemenyah, Joon Lee, Lalit Kaurani, Gregor Eichele, Markus Zweckstetter, Gaurav Jain, Nasrollah Rezaei-Ghaleh, Andre Fischer, Alan L. Gillman, Gayane Grigorian, Ratnesh Lal, Sergey Ryazanov, Mario Caruana, Armin Giese, Christian Griesinger, Martin Korte, Eva Benito, Angelique Camilleri, Andrei Leonov, Neville Vassallo, Jens Wagner, Fernando Teran Arce, Hendrik Urbanke, Ana Martinez Hernandez, Anja Schneider, Petra Wilken

Publikováno v: EMBO Molecular Medicine
EMBO molecular medicine 10(1), 32-47 (2018). doi:10.15252/emmm.201707825
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 32-47 (2018)
EMBO molecular medicine
EMBO molecular medicine, vol 10, iss 1

Alzheimer’s disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136f4a325e014173319325e91132fab8

microRNA-34c is a novel target to treat dementias

Autor: Andrea Schmitt, Pooja Rao, Laurent Farinelli, Athanasios Zovoilis, Ivana Delalle, Hope Y Agbemenyah, Dieter Edbauer, Roberto Carlos Agis-Balboa, Roman M. Stilling, Farahnaz Sananbenesi, Andre Fischer, Sanaz Bahari-Javan, Peter Falkai, Susanne Burkhardt

Publikováno v: The EMBO Journal. 30:4299-4308

MicroRNAs are key regulators of transcriptome plasticity and have been implicated with the pathogenesis of brain diseases. Here, we employed massive parallel sequencing and provide, at an unprecedented depth, the complete and quantitative miRNAome of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b9d1e81c578fdbc45f7b3ac354f5369
https://doi.org/10.1038/emboj.2011.327