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Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.

Autor: Rondeau V; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada., Berman JM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada., Ling T; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., O'Brien C; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., Culp-Hill R; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045 USA., Reisz JA; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045 USA., Wunderlich M; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH 45229 USA., Chueh Y; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH 45229 USA., Jiménez-Camacho KE; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH 45229 USA., Sexton C; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH 45229 USA., Carter KM; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH 45229 USA., Stillwell C; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH 45229 USA., St-Germain J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada., Yendi D; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., Gupta A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada., Shi M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada., Bourdine A; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., Paralkar VR; Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104 USA., Jahangiri S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., Hope KJ; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., Tikhonova AN; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., Arruda A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada., Minden MD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., Raught B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045 USA., Jones CL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada.; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH 45229 USA.; Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229 USA.; University of Cincinnati Cancer Center, Cincinnati, OH 45229 USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Sep 25; Vol. 16 (766), pp. eadn1285. Date of Electronic Publication: 2024 Sep 25.

In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target.

Autor: Vujovic A; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada., de Rooij L; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada., Chahi AK; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada., Chen HT; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada., Yee BA; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California., Loganathan SK; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada., Liu L; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada., Chan DCH; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada., Tajik A; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada., Tsao E; Department of Medical Biophysics, University of Toronto, Toronto, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada., Moreira S; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada., Joshi P; Department of Medical Biophysics, University of Toronto, Toronto, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada., Xu J; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada., Wong N; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada., Balde Z; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada., Jahangiri S; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada., Zandi S; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Aigner S; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California., Dick JE; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Minden MD; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.; Faculty of Medicine, University of Toronto, Toronto, Canada., Schramek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Yeo GW; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California., Hope KJ; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

Publikováno v: Blood cancer discovery [Blood Cancer Discov] 2023 May 01; Vol. 4 (3), pp. 180-207.

The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors.

Autor: Liu L; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Vujovic A; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Deshpande NP; Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.; Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia., Sathe S; Department of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, San Diego, CA, USA., Anande G; Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.; Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia., Chen HTT; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Xu J; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Minden MD; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Yeo GW; Department of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, San Diego, CA, USA., Unnikrishnan A; Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.; Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia., Hope KJ; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. kristin.hope@uhnresearch.ca.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. kristin.hope@uhnresearch.ca., Lu Y; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada. yu.lu@mcmaster.ca.

Publikováno v: Nature communications [Nat Commun] 2022 Jul 04; Vol. 13 (1), pp. 3833. Date of Electronic Publication: 2022 Jul 04.