Výsledky vyhledávání - "Hope J Haime"

Akademický článek

Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism.

Autor: Benjamin P Towler, Amy L Pashler, Hope J Haime, Katarzyna M Przybyl, Sandra C Viegas, Rute G Matos, Simon J Morley, Cecilia M Arraiano, Sarah F Newbury

Publikováno v: PLoS Genetics, Vol 16, Iss 12, p e1009297 (2020)

Dis3L2 is a highly conserved 3'-5' exoribonuclease which is mutated in the human overgrowth disorders Perlman syndrome and Wilms' tumour of the kidney. Using Drosophila melanogaster as a model system, we have generated a new dis3L2 null mutant togeth

Externí odkaz: https://doaj.org/article/40e47af13bbb47ccbf12f41aad24d536

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Genome-wide analyses of XRN1-sensitive targets in osteosarcoma cells identify disease-relevant transcripts containing G-rich motifs

Autor: Christopher I. Jones, Hope J. Haime, Sarah F. Newbury, Amy L. Pashler, Benjamin P. Towler, Tom Burgess

Publikováno v: RNA

XRN1 is a highly conserved exoribonuclease which degrades uncapped RNAs in a 5′–3′ direction. Degradation of RNAs by XRN1 is important in many cellular and developmental processes and is relevant to human disease. Studies in D. melanogaster dem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1af45305a5b1e2fbca3bd7116f9d56
https://europepmc.org/articles/PMC8457002/

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Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism

Autor: Rute G. Matos, Benjamin P. Towler, Sandra C. Viegas, Sarah F. Newbury, Hope J. Haime, Amy L. Pashler, Cecília M. Arraiano, Katarzyna M. Przybyl, Simon J. Morley

Publikováno v: PLoS Genetics, Vol 16, Iss 12, p e1009297 (2020)
PLoS Genetics

Dis3L2 is a highly conserved 3’-5’ exoribonuclease which is mutated in the human overgrowth disorders Perlman syndrome and Wilms’ tumour of the kidney. Using Drosophila melanogaster as a model system, we have generated a new dis3L2 null mutant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f86333280b7ea7fe4b26c18f4d94981b
https://doaj.org/article/40e47af13bbb47ccbf12f41aad24d536

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Dis3L2 regulates cellular proliferation through a PI3-Kinase dependent signalling pathway

Autor: Sarah F. Newbury, Sandra C. Viegas, Cecília M. Arraiano, Katarzyna M. Przybyl, Simon J. Morley, Benjamin P. Towler, Hope J. Haime, Rute G. Matos, Amy L. Pashler

Dis3L2 is a highly conserved 3’-5’ exoribonuclease which is mutated in the human overgrowth disorders Perlman syndrome and Wilms’ tumour. Here, we have generated a newdis3L2 null mutant and a UAS-nuclease-dead line inDrosophilato demonstrate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecda7768973b266a1b43b059014cda67

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