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PGE 2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function.

Autor: Morotti M; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Grimm AJ; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Hope HC; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Arnaud M; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Desbuisson M; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Rayroux N; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Barras D; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Masid M; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Murgues B; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Chap BS; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Ongaro M; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Rota IA; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Ronet C; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Minasyan A; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Chiffelle J; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Lacher SB; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Bobisse S; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Murgues C; Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Ghisoni E; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Ouchen K; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Bou Mjahed R; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Benedetti F; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Abdellaoui N; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Turrini R; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland., Gannon PO; Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Zaman K; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Mathevet P; Department of Gynaecology, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Lelievre L; Department of Gynaecology, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Crespo I; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Conrad M; Institute of Metabolism and Cell Death, Molecular Target and Therapeutics Centre, Helmholtz Munich, Neuherberg, Germany., Verdeil G; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Kandalaft LE; Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Dagher J; Unit of Translational Oncopathology, Institute of Pathology, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Corria-Osorio J; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Doucey MA; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland., Ho PC; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Harari A; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Vannini N; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Böttcher JP; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Dangaj Laniti D; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland. denarda.dangaj@chuv.ch.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland. denarda.dangaj@chuv.ch.; Agora Cancer Research Center, Lausanne, Switzerland. denarda.dangaj@chuv.ch., Coukos G; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland. george.coukos@chuv.ch.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland. george.coukos@chuv.ch.; Agora Cancer Research Center, Lausanne, Switzerland. george.coukos@chuv.ch.

Publikováno v: Nature [Nature] 2024 May; Vol. 629 (8011), pp. 426-434. Date of Electronic Publication: 2024 Apr 24.