Characterization of pathogenic germline mutations in human Protein Kinases

Autor: Orengo Christine A, Baresic Anja, Hopcroft Lisa EM, Izarzugaza Jose MG, Martin Andrew CR, Valencia Alfonso

Publikováno v: BMC Bioinformatics, Vol 12, Iss Suppl 4, p S1 (2011)

Abstract Background Protein Kinases are a superfamily of proteins involved in crucial cellular processes such as cell cycle regulation and signal transduction. Accordingly, they play an important role in cancer biology. To contribute to the study of

Externí odkaz: https://doaj.org/article/12267c4eb50f4056a62b76af092d7343

CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression

Autor: Tarafdar, Anuradha, Hopcroft, Lisa EM, Gallipoli, Paolo, Pellicano, Francesca, Cassels, Jennifer, Hair, Alan, Korfi, Koorosh, Jørgensen, Heather G, Vetrie, David, Holyoake, Tessa L, Michie, Alison M

Targeting the fusion oncoprotein BCR-ABL with tyrosine kinase inhibitors has significantly affected chronic myeloid leukemia (CML) treatment, transforming the life expectancy of patients; however the risk for relapse remains, due to persistence of le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::598995fb80366de42e10e31ccbba1ff8

Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics.

Autor: Fisher L; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Hopcroft LE; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Rodgers S; PRIMIS, School of Medicine, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK., Barrett J; PRIMIS, School of Medicine, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK., Oliver K; PRIMIS, School of Medicine, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK., Avery AJ; Centre for Academic Primary Care, School of Medicine, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK., Evans D; PRIMIS, School of Medicine, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK., Curtis H; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Croker R; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Macdonald O; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Morley J; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Mehrkar A; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Bacon S; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Davy S; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Dillingham I; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Evans D; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Hickman G; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Inglesby P; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Morton CE; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Smith B; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Ward T; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Hulme W; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Green A; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Massey J; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Walker AJ; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., Bates C; TPP, Leeds, UK., Cockburn J; TPP, Leeds, UK., Parry J; TPP, Leeds, UK., Hester F; TPP, Leeds, UK., Harper S; TPP, Leeds, UK., O'Hanlon S; EMIS Health, Leeds, UK., Eavis A; EMIS Health, Leeds, UK., Jarvis R; EMIS Health, Leeds, UK., Avramov D; EMIS Health, Leeds, UK., Griffiths P; EMIS Health, Leeds, UK., Fowles A; EMIS Health, Leeds, UK., Parkes N; EMIS Health, Leeds, UK., Goldacre B; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK., MacKenna B; Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK.

Publikováno v: BMJ medicine [BMJ Med] 2023 May 11; Vol. 2 (1), pp. e000392. Date of Electronic Publication: 2023 May 11 (Print Publication: 2023).