Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Hop CE"'
Akademický článek
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Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Takahashi RH; Departments of Drug Metabolism and Pharmacokinetics (R.H.T., J.S.H., Y.C., C.E.C.A.H., S.C.K., S.M.), and Discovery Chemistry (M.S.), Genentech, Inc., 1 DNA Way, South San Francisco, California takahashi.ryan@gene.com., Halladay JS; Departments of Drug Metabolism and Pharmacokinetics (R.H.T., J.S.H., Y.C., C.E.C.A.H., S.C.K., S.M.), and Discovery Chemistry (M.S.), Genentech, Inc., 1 DNA Way, South San Francisco, California., Siu M; Departments of Drug Metabolism and Pharmacokinetics (R.H.T., J.S.H., Y.C., C.E.C.A.H., S.C.K., S.M.), and Discovery Chemistry (M.S.), Genentech, Inc., 1 DNA Way, South San Francisco, California., Chen Y; Departments of Drug Metabolism and Pharmacokinetics (R.H.T., J.S.H., Y.C., C.E.C.A.H., S.C.K., S.M.), and Discovery Chemistry (M.S.), Genentech, Inc., 1 DNA Way, South San Francisco, California., Hop CE; Departments of Drug Metabolism and Pharmacokinetics (R.H.T., J.S.H., Y.C., C.E.C.A.H., S.C.K., S.M.), and Discovery Chemistry (M.S.), Genentech, Inc., 1 DNA Way, South San Francisco, California., Khojasteh SC; Departments of Drug Metabolism and Pharmacokinetics (R.H.T., J.S.H., Y.C., C.E.C.A.H., S.C.K., S.M.), and Discovery Chemistry (M.S.), Genentech, Inc., 1 DNA Way, South San Francisco, California., Ma S; Departments of Drug Metabolism and Pharmacokinetics (R.H.T., J.S.H., Y.C., C.E.C.A.H., S.C.K., S.M.), and Discovery Chemistry (M.S.), Genentech, Inc., 1 DNA Way, South San Francisco, California.
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2017 May; Vol. 45 (5), pp. 430-440. Date of Electronic Publication: 2017 Feb 10.
Autor:
Takahashi RH; a Department of Drug Metabolism and Pharmacokinetics , Genentech, Inc. , South San Francisco , CA , USA., Ma S; a Department of Drug Metabolism and Pharmacokinetics , Genentech, Inc. , South San Francisco , CA , USA., Yue Q; a Department of Drug Metabolism and Pharmacokinetics , Genentech, Inc. , South San Francisco , CA , USA., Kim-Kang H; b XenoBiotic Laboratories, Inc , Plainsboro , NJ , USA., Yi Y; b XenoBiotic Laboratories, Inc , Plainsboro , NJ , USA., Ly J; a Department of Drug Metabolism and Pharmacokinetics , Genentech, Inc. , South San Francisco , CA , USA., Boggs JW; a Department of Drug Metabolism and Pharmacokinetics , Genentech, Inc. , South San Francisco , CA , USA., Fettes A; c Pharma Technical Development, Process Research & Development, F. Hoffmann-La Roche Ltd , Basel , Switzerland , and., McClory A; d Small Molecule Process Chemistry, Genentech, Inc. , South San Francisco , CA , USA., Deng Y; a Department of Drug Metabolism and Pharmacokinetics , Genentech, Inc. , South San Francisco , CA , USA., Hop CE; a Department of Drug Metabolism and Pharmacokinetics , Genentech, Inc. , South San Francisco , CA , USA., Khojasteh SC; a Department of Drug Metabolism and Pharmacokinetics , Genentech, Inc. , South San Francisco , CA , USA., Choo EF; a Department of Drug Metabolism and Pharmacokinetics , Genentech, Inc. , South San Francisco , CA , USA.
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2017 Jan; Vol. 47 (1), pp. 50-65. Date of Electronic Publication: 2016 Apr 08.
Autor:
Ma Y; Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California., Khojasteh SC; Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California., Hop CE; Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California., Erickson HK; Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California., Polson A; Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California., Pillow TH; Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California., Yu SF; Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California., Wang H; Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California., Dragovich PS; Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California., Zhang D; Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California zhang.donglu@gene.com.
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2016 Dec; Vol. 44 (12), pp. 1958-1962. Date of Electronic Publication: 2016 Sep 28.
Autor:
Wang L; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Collins C; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Kelly EJ; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Chu X; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Ray AS; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Salphati L; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Xiao G; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Lee C; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Lai Y; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Liao M; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Mathias A; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Evers R; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Humphreys W; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Hop CE; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Kumer SC; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.)., Unadkat JD; Department of Pharmaceutics, University of Washington, Seattle, Washington (L.W., C.C., E.J.K., J.D.U.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Rahway, New Jersey (X.C.); Departments of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Gilead Sciences, Inc., Foster City, California (A.S.R., A.M.); Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California (L.S., C.E.C.A.H.); Preclinical PK and In Vitro ADME, Biogen, Cambridge, Massachusetts (G.X.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Ardea Biosciences, Inc., San Diego, California (C.L.); Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Princeton, New Jersey (Y.L.,W.H.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (M.L.); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey (R.E.); Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas (S.C.K.) jash@uw.edu.
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2016 Nov; Vol. 44 (11), pp. 1752-1758. Date of Electronic Publication: 2016 Aug 19.
Autor:
Shah P; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville Maryland (P.S, E.K, D-T.N, A Q.W, A.Z, J.M, A.S, X.X.); Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer. Groton, Connecticut (R.S.O.); and Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California (C.E.C.A.H)., Kerns E; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville Maryland (P.S, E.K, D-T.N, A Q.W, A.Z, J.M, A.S, X.X.); Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer. Groton, Connecticut (R.S.O.); and Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California (C.E.C.A.H)., Nguyen DT; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville Maryland (P.S, E.K, D-T.N, A Q.W, A.Z, J.M, A.S, X.X.); Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer. Groton, Connecticut (R.S.O.); and Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California (C.E.C.A.H)., Obach RS; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville Maryland (P.S, E.K, D-T.N, A Q.W, A.Z, J.M, A.S, X.X.); Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer. Groton, Connecticut (R.S.O.); and Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California (C.E.C.A.H)., Wang AQ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville Maryland (P.S, E.K, D-T.N, A Q.W, A.Z, J.M, A.S, X.X.); Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer. Groton, Connecticut (R.S.O.); and Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California (C.E.C.A.H)., Zakharov A; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville Maryland (P.S, E.K, D-T.N, A Q.W, A.Z, J.M, A.S, X.X.); Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer. Groton, Connecticut (R.S.O.); and Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California (C.E.C.A.H)., McKew J; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville Maryland (P.S, E.K, D-T.N, A Q.W, A.Z, J.M, A.S, X.X.); Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer. Groton, Connecticut (R.S.O.); and Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California (C.E.C.A.H)., Simeonov A; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville Maryland (P.S, E.K, D-T.N, A Q.W, A.Z, J.M, A.S, X.X.); Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer. Groton, Connecticut (R.S.O.); and Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California (C.E.C.A.H)., Hop CE; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville Maryland (P.S, E.K, D-T.N, A Q.W, A.Z, J.M, A.S, X.X.); Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer. Groton, Connecticut (R.S.O.); and Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California (C.E.C.A.H)., Xu X; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville Maryland (P.S, E.K, D-T.N, A Q.W, A.Z, J.M, A.S, X.X.); Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer. Groton, Connecticut (R.S.O.); and Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California (C.E.C.A.H) xin.xu3@nih.gov.
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2016 Oct; Vol. 44 (10), pp. 1653-61. Date of Electronic Publication: 2016 Jul 14.
Autor:
Zhang D; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California zhang.donglu@gene.com., Yu SF; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California., Ma Y; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California., Xu K; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California., Dragovich PS; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California., Pillow TH; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California., Liu L; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California., Del Rosario G; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California., He J; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California., Pei Z; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California., Sadowsky JD; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California., Erickson HK; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California., Hop CE; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California., Khojasteh SC; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2016 Sep; Vol. 44 (9), pp. 1517-23. Date of Electronic Publication: 2016 Jul 14.
Autor:
Zhang D; Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States., Pillow TH; Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States., Ma Y; Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States., Cruz-Chuh JD; Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States., Kozak KR; Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States., Sadowsky JD; Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States., Lewis Phillips GD; Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States., Guo J; Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States., Darwish M; Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States., Fan P; Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States., Chen J; Wuxi Apptec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., He C; Wuxi Apptec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Wang T; Wuxi Apptec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Yao H; Wuxi Apptec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Xu Z; Wuxi Apptec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Chen J; Wuxi Apptec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Wai J; Wuxi Apptec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China., Pei Z; Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States., Hop CE; Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States., Khojasteh SC; Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States., Dragovich PS; Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States.
Publikováno v:
ACS medicinal chemistry letters [ACS Med Chem Lett] 2016 Aug 26; Vol. 7 (11), pp. 988-993. Date of Electronic Publication: 2016 Aug 26 (Print Publication: 2016).
Autor:
Malhi V; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. vmalhi@gmail.com., Colburn D; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA., Williams SJ; F. Hoffmann-La Roche, Ltd., Welwyn Garden City, UK., Hop CE; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA., Dresser MJ; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.; Denali Therapeutics, South San Francisco, CA, USA., Chandra P; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA., Graham RA; Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.; Theravance Biopharma, South San Francisco, CA, USA.
Publikováno v:
Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2016 Jul; Vol. 78 (1), pp. 41-9. Date of Electronic Publication: 2016 May 06.