Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Hoon Ki Sung"'
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 27 (2024)
Obesity, characterised by excessive fat accumulation, is a complex chronic condition that results from dysfunctional adipose tissue expansion due to prolonged calorie surplus. This leads to rapid adipocyte enlargement that exceeds the support capacit
Externí odkaz:
https://doaj.org/article/084d246f9c104f8facad37de44a98276
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7173 (2024)
Multiple alterations of cellular metabolism have been documented in experimental studies of autosomal dominant polycystic kidney disease (ADPKD) and are thought to contribute to its pathogenesis. To elucidate the molecular pathways and transcriptiona
Externí odkaz:
https://doaj.org/article/f8c66bf59b764c44ade7c946b41f5abb
Autor:
Carly M. Knuth, Dalia Barayan, Ju Hee Lee, Christopher Auger, Lauar de Brito Monteiro, Zachary Ricciuti, Dea Metko, Lisa Wells, Hoon-Ki Sung, Robert A. Screaton, Marc G. Jeschke
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113584- (2024)
Summary: Severe burns induce a chronic hypermetabolic state that persists well past wound closure, indicating that additional internal mechanisms must be involved. Adipose tissue is suggested to be a central regulator in perpetuating hypermetabolism,
Externí odkaz:
https://doaj.org/article/28447df79fd644b48867df243ef615fa
Autor:
Daniel J. Han, Rukhsana Aslam, Paraish S. Misra, Felix Chiu, Tanvi Ojha, Apu Chowdhury, Carmen K. Chan, Hoon-Ki Sung, Darren A. Yuen, Cynthia T. Luk
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101594- (2022)
Objective: Adipose tissue is a very dynamic metabolic organ that plays an essential role in regulating whole-body glucose homeostasis. Dysfunctional adipose tissue hypertrophy with obesity is associated with fibrosis and type 2 diabetes. Yes-associat
Externí odkaz:
https://doaj.org/article/0cd4e995ce7b4cab97303ebcb9db4249
Autor:
Ioan-Andrei Iliuta, Xuewen Song, Lauren Pickel, Amirreza Haghighi, Ravi Retnakaran, James Scholey, Hoon-Ki Sung, Gregory R. Steinberg, York Pei
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Autosomal dominant polycystic kidney disease (ADPKD) is the most common Mendelian kidney disease, affecting approximately one in 1,000 births and accounting for 5% of end-stage kidney disease in developed countries. The pathophysiology of ADPKD is st
Externí odkaz:
https://doaj.org/article/64294a91b9344907a2afb96f3746a588
Autor:
Lauren Pickel, Ju Hee Lee, Heather Maughan, Irisa Qianwen Shi, Navkiran Verma, Christy Yeung, David Guttman, Hoon‐Ki Sung
Publikováno v:
Physiological Reports, Vol 10, Iss 14, Pp n/a-n/a (2022)
Abstract The circadian clock regulates metabolism in anticipation of regular changes in the environment. It is found throughout the body, including in key metabolic organs such as the liver, adipose tissues, and intestine, where the timing of the clo
Externí odkaz:
https://doaj.org/article/090aab6e62a04ea697ebf2b00ca5a670
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 863 (2023)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons, leading to muscle weakness, paralysis, and eventual death. Research from the past few decades has appreciated that ALS is not only a disease of the motor n
Externí odkaz:
https://doaj.org/article/b4da20ef4d6a4a0ea6ecaf373a500652
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences; 2024, p1-14, 14p
Autor:
Ju Hee Lee, Kafi N. Ealey, Yash Patel, Navkiran Verma, Nikita Thakkar, So Young Park, Jae-Ryong Kim, Hoon-Ki Sung
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104166- (2022)
Summary: The increased prevalence of obesity and metabolic diseases has heightened interest in adipose tissue biology and its potential as a therapeutic target. To better understand cellular heterogeneity and complexity of white adipose tissue (WAT),
Externí odkaz:
https://doaj.org/article/400700490d4547adb8c5b7d1528830a2
Autor:
Ji-Eun Kim, Lijiang Fei, Wen-Chi Yin, Sabrina Coquenlorge, Abilasha Rao-Bhatia, Xiaoyun Zhang, Sammy Shun Wai Shi, Ju Hee Lee, Noah A. Hahn, Wasi Rizvi, Kyoung-Han Kim, Hoon-Ki Sung, Chi-chung Hui, Guoji Guo, Tae-Hee Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Wnt signals for intestinal stem cell self-renewal originate from the stroma and Paneth cells, but the source in stomach is unclear. Here the authors identify a conserved population of stromal cells adjacent to stomach epithelia where Gli2 activates W
Externí odkaz:
https://doaj.org/article/f2afc39b87d4469eb7631c0d62df5b58