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Novel Adjuvant S-540956 Targets Lymph Nodes and Reduces Genital Recurrences and Vaginal Shedding of HSV-2 DNA When Administered with HSV-2 Glycoprotein D as a Therapeutic Vaccine in Guinea Pigs.

Autor: Awasthi S; Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6073, USA., Onishi M; Pharmaceutical Research Division, Shionogi & Co., Ltd., Osaka 561-0825, Japan., Lubinski JM; Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6073, USA., Fowler BT; Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6073, USA., Naughton AM; Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6073, USA., Hook LM; Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6073, USA., Egan KP; Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6073, USA., Hagiwara M; Pharmaceutical Research Division, Shionogi & Co., Ltd., Osaka 561-0825, Japan., Shirai S; Pharmaceutical Research Division, Shionogi & Co., Ltd., Osaka 561-0825, Japan., Sakai A; Pharmaceutical Research Division, Shionogi & Co., Ltd., Osaka 561-0825, Japan., Nakagawa T; Pharmaceutical Research Division, Shionogi & Co., Ltd., Osaka 561-0825, Japan., Goto K; Pharmaceutical Research Division, Shionogi & Co., Ltd., Osaka 561-0825, Japan., Yoshida O; Pharmaceutical Research Division, Shionogi & Co., Ltd., Osaka 561-0825, Japan., Stephens AJ; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6073, USA., Choi G; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6073, USA., Cohen GH; Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104-6073, USA., Katayama K; Pharmaceutical Research Division, Shionogi & Co., Ltd., Osaka 561-0825, Japan., Friedman HM; Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6073, USA.

Publikováno v: Viruses [Viruses] 2023 May 10; Vol. 15 (5). Date of Electronic Publication: 2023 May 10.

Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models.

Autor: Awasthi S; Infectious Disease Division, Department of Medicine and., Knox JJ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Desmond A; Infectious Disease Division, Department of Medicine and.; Infectious Disease Division, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Alameh MG; Infectious Disease Division, Department of Medicine and., Gaudette BT; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lubinski JM; Infectious Disease Division, Department of Medicine and., Naughton A; Infectious Disease Division, Department of Medicine and., Hook LM; Infectious Disease Division, Department of Medicine and., Egan KP; Infectious Disease Division, Department of Medicine and., Tam YK; Acuitas Therapeutics Inc., Vancouver, British Columbia, Canada., Pardi N; Infectious Disease Division, Department of Medicine and., Allman D; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Luning Prak ET; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Cancro MP; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Weissman D; Infectious Disease Division, Department of Medicine and., Cohen GH; Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Friedman HM; Infectious Disease Division, Department of Medicine and.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2021 Dec 01; Vol. 131 (23).

Techniques for Characterizing Cytomegalovirus-Encoded miRNAs.

Autor: Diggins NL; Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, Beaverton, OR, USA., Crawford LB; Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, Beaverton, OR, USA., Struthers HM; Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, Beaverton, OR, USA., Hook LM; Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, Beaverton, OR, USA., Landais I; Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, Beaverton, OR, USA., Skalsky RL; Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, Beaverton, OR, USA., Hancock MH; Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, Beaverton, OR, USA. hancocme@ohsu.edu.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2244, pp. 301-342.