Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Hooi-ling Ng"'
Autor:
Michael W. Parker, Ying Ting Yang, Phillip J. Daborn, Christopher Lumb, Philip J. Batterham, Emily J. Remnant, Craig J. Morton, Hooi Ling Ng
Publikováno v:
Insect Biochemistry and Molecular Biology. 54:11-21
Extensive use of older generation insecticides may result in pre-existing cross-resistance to new chemical classes acting at the same target site. Phenylpyrazole insecticides block inhibitory neurotransmission in insects via their action on ligand-ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985ecd58451e467b79990295ecd6c79e
https://doi.org/10.1016/j.ibmb.2014.08.008
https://doi.org/10.1016/j.ibmb.2014.08.008
Autor:
T. John Martin, David T. Manallack, Nancy C. Hancock, Patricia W. M. Ho, Ian G. Jennings, Jessica K. Holien, Hooi-Ling Ng, Craig J. Morton, Susanne C. Feil, Jacob L. Nankervis, Philip E. Thompson, Mark Frazzetto, Michael W. Parker, Zhaohua Zheng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7089-7093
PDE4 inhibitors have been identified as therapeutic targets for a variety of conditions, particularly inflammatory diseases. We have serendipitously identified a novel class of phosphodiesterase 4 (PDE4) inhibitor during a study to discover antagonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9151dd8cd0212547ca40e0e744bbc78d
https://doi.org/10.1016/j.bmcl.2011.09.109
https://doi.org/10.1016/j.bmcl.2011.09.109
Autor:
Michael Bieri, Malcolm J. McConville, James Pyke, Yee-Foong Mok, Susanne C. Feil, Craig J. Morton, Wai Yee Low, Paul R. Gooley, Charles Robin, Hooi Ling Ng, Michael W. Parker, Michael A. Gorman, Philip J. Batterham
Publikováno v:
Journal of Molecular Biology. 399:358-366
GSTD1 is one of several insect glutathione S-transferases capable of metabolizing the insecticide DDT. Here we use crystallography and NMR to elucidate the binding of DDT and glutathione to GSTD1. The crystal structure of Drosophila melanogaster GSTD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c3ad87481ae83f2fdcdebd39523a70
https://doi.org/10.1016/j.jmb.2010.04.020
https://doi.org/10.1016/j.jmb.2010.04.020
Autor:
Hooi Ling Ng, Luke A. Miles, David B. Ascher, Craig J. Morton, Gabriela A. N. Crespi, Michael W. Parker
Publikováno v:
Journal of Proteomics & Bioinformatics. :464-476
Cognitive decline most commonly associated with Alzheimer’s dementia can also result from other conditions including cerebral ischemia or brain trauma. One quarter of people over the age of 65 are estimated to suffer some form of cognitive impairme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3d2c4bb92bd9e9908c9ebfcc3373237
https://doi.org/10.4172/jpb.1000054
https://doi.org/10.4172/jpb.1000054
Autor:
Siew Yeen Chai, Frederick A.O. Mendelsohn, Anthony L. Albiston, Hooi Ling Ng, Ruani N Fernando, Holly R Yeatman, Dimitri De Bundel, Vi Pham, Siying Ye, David B. Ascher, Craig J. Morton, Michael W. Parker
Publikováno v:
The FASEB Journal. 22:4209-4217
Approximately one-quarter of people over the age of 65 are estimated to suffer some form of cognitive impairment, underscoring the need for effective cognitive-enhancing agents. Insulin-regulated aminopeptidase (IRAP) is potentially an innovative tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79265b6e8a895aff260ae816f75bd51
https://doi.org/10.1096/fj.08-112227
https://doi.org/10.1096/fj.08-112227
Autor:
Michael W. Parker, Roberto Cappai, William J. McKinstry, Craig J. Morton, Gabriela A. N. Crespi, Luke A. Miles, Hooi Ling Ng, Kevin J. Barnham, Geoffrey Kwai-Wai Kong
Publikováno v:
European Biophysics Journal
Alzheimer's disease is the fourth biggest killer in developed countries. Amyloid precursor protein (APP) plays a central role in the development of the disease, through the generation of a peptide called A beta by proteolysis of the precursor protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6fdabc368e9ec3863608107a18a857
https://doi.org/10.1007/s00249-007-0234-3
https://doi.org/10.1007/s00249-007-0234-3
Publikováno v:
Journal of Neurochemistry. 98:395-407
Ginkgolides are potent blockers of the glycine receptor Cl- channel (GlyR) pore. We sought to identify their binding sites by comparing the effects of ginkgolides A, B and C and bilobalide on alpha1, alpha2, alpha1beta and alpha2beta GlyRs. Bilobalid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6405a1e46ef184c33b29d47689b43ec
https://doi.org/10.1111/j.1471-4159.2006.03875.x
https://doi.org/10.1111/j.1471-4159.2006.03875.x
Autor:
Michael W. Parker, Brett Bennetts, Hooi-Ling Ng, Craig J. Morton, David Stapleton, Brett A. Cromer, Grigori Y. Rychkov
Publikováno v:
Journal of Biological Chemistry. 280:32452-32458
ClC proteins are a family of chloride channels and transporters that are found in a wide variety of prokaryotic and eukaryotic cell types. The mammalian voltage-gated chloride channel ClC-1 is important for controlling the electrical excitability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c2ad5c910181f451c9cb385b4999d6
https://doi.org/10.1074/jbc.m502890200
https://doi.org/10.1074/jbc.m502890200
Autor:
Charles Robin, Michael W. Parker, Philip J. Batterham, Hooi Ling Ng, Craig J. Morton, Wai Yee Low
As classical phase II detoxification enzymes, glutathione S-transferases (GSTs) have been implicated in insecticide resistance and may have evolved in response to toxins in the niche-defining feeding substrates of Drosophila species. We have annotate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91303d277f6a8df109c39a994d5a535
https://europepmc.org/articles/PMC2147980/
https://europepmc.org/articles/PMC2147980/
Autor:
Rong Li, Juliana Soosairajah, Daniel Harari, Ami Citri, John Price, Hooi Ling Ng, Craig J. Morton, Michael W. Parker, Yosef Yarden, Ora Bernard
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20(8)
LIM kinase 1 (LIMK1) is a serine protein kinase that regulates the actin cytoskeleton by phosphorylation and inactivation of actin depolymerizing factor cofilin. LIMK1 activity is regulated by the Rho-GTPases via their serine/threonine kinase effecto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2402b7d8fd5606f231016bfa26e20f3
https://pubmed.ncbi.nlm.nih.gov/16641196
https://pubmed.ncbi.nlm.nih.gov/16641196