Safety and effectiveness of SGM-101, a fluorescent antibody targeting carcinoembryonic antigen, for intraoperative detection of colorectal cancer: a dose-escalation pilot study

Autor: Boogerd, Leonora S F, Hoogstins, Charlotte E S, Schaap, Dennis P, Kusters, Miranda, Handgraaf, Henricus J M, van der Valk, Maxime J M, Hilling, Denise E, Holman, Fabian A, Peeters, Koen C M J, Mieog, J Sven D, van de Velde, Cornelis J H, Farina-Sarasqueta, Arantza, van Lijnschoten, Ineke, Framery, Bérénice, Pèlegrin, André, Gutowski, Marian, Nienhuijs, Simon W, de Hingh, Ignace H J T, Nieuwenhuijzen, Grard A P, Rutten, Harm J T, Cailler, Francoise, Burggraaf, Jacobus, Vahrmeijer, Alexander L

Publikováno v: In The Lancet Gastroenterology & Hepatology March 2018 3(3):181-191

Data from A Novel Tumor-Specific Agent for Intraoperative Near-Infrared Fluorescence Imaging: A Translational Study in Healthy Volunteers and Patients with Ovarian Cancer

Autor: Alexander L. Vahrmeijer, Jacobus Burggraaf, Philip S. Low, Adam F. Cohen, Cornelis J.H. van de Velde, Jaap Vuyk, Vincent T.H.B.M. Smit, Tjalling Bosse, J. Baptist M.Z. Trimbos, Cor D. de Kroon, Katja N. Gaarenstroom, Quirijn R.J.G. Tummers, Charlotte E.S. Hoogstins

Purpose: Completeness of cytoreductive surgery is a key prognostic factor for survival in patients with ovarian cancer. The ability to differentiate clearly between malignant and healthy tissue is essential for achieving complete cytoreduction. Using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b075cc00094200ed9c44d0c353785730
https://doi.org/10.1158/1078-0432.c.6524033

Supplementary Materials from A Novel Tumor-Specific Agent for Intraoperative Near-Infrared Fluorescence Imaging: A Translational Study in Healthy Volunteers and Patients with Ovarian Cancer

Autor: Alexander L. Vahrmeijer, Jacobus Burggraaf, Philip S. Low, Adam F. Cohen, Cornelis J.H. van de Velde, Jaap Vuyk, Vincent T.H.B.M. Smit, Tjalling Bosse, J. Baptist M.Z. Trimbos, Cor D. de Kroon, Katja N. Gaarenstroom, Quirijn R.J.G. Tummers, Charlotte E.S. Hoogstins

Supplementary Material and Methods: questionnaire for practical evaluation of OTL38 and the imaging system; description of immunohistochemistry and fluorescence microscopy. Fig. S1: Case report form (CRF) used to mark the location of a lesion found d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778273b46f3e3b69d7bbc48eadede9b2
https://doi.org/10.1158/1078-0432.22458758

Dose-Finding Study of a CEA-Targeting Agent, SGM-101, for Intraoperative Fluorescence Imaging of Colorectal Cancer

Autor: Shadhvi S. Bhairosingh, Koen C.M.J. Peeters, Dennis P. Schaap, Kim S. de Valk, Charlotte E.S. Hoogstins, Denise E. Hilling, Bérénice Framery, Fabian A. Holman, Leonora S.F. Boogerd, Miranda Kusters, Maxime J M van der Valk, Françoise Cailler, Marion M. Deken, Jacobus Burggraaf, Ruben P J Meijer, Harm J. T. Rutten, Ingrid M C Kamerling, Alexander L. Vahrmeijer

Publikováno v: Annals of Surgical Oncology, 28, 1832-1844. SPRINGER
Annals of surgical oncology, 28(3), 1832-1844. Springer New York
Annals of Surgical Oncology, 28(3), 1832-1844. Springer New York
Annals of Surgical Oncology
de Valk, K S, Deken, M M, Schaap, D P, Meijer, R P, Boogerd, L S, Hoogstins, C E, van der Valk, M J, Kamerling, I M, Bhairosingh, S S, Framery, B, Hilling, D E, Peeters, K C, Holman, F A, Kusters, M, Rutten, H J, Cailler, F, Burggraaf, J & Vahrmeijer, A L 2021, ' Dose-Finding Study of a CEA-Targeting Agent, SGM-101, for Intraoperative Fluorescence Imaging of Colorectal Cancer ', Annals of Surgical Oncology, vol. 28, no. 3, pp. 1832-1844 . https://doi.org/10.1245/s10434-020-09069-2

BackgroundCarcinoembryonic antigen is overexpressed in colorectal cancer (CRC), making it an optimal target for fluorescence imaging. A phase I/II study was designed to determine the optimal imaging dose of SGM-101 for intraoperative fluorescence ima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8459e9d0dca4d305c1b07195f390feed
http://www.scopus.com/inward/record.url?scp=85092351518&partnerID=8YFLogxK

Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of patients with VEXAS

Autor: Mihai G. Netea, David B. Beck, A. Elizabeth Hak, Huub P.J. Willems, Pieter van Paassen, Caspar I van der Made, Marielle E. van Gijn, Frank L. van de Veerdonk, Arjan J. Kwakernaak, Lars T. van der Veken, Marloes W Heijstek, Annemiek Hoogstins, Alexander Hoischen, Ruud G. L. de Sévaux, Helen L. Leavis, Paul L A van Daele, Abraham Rutgers, Judith Potjewijd, Annet Simons

Publikováno v: Journal of Allergy and Clinical Immunology, 149, 1, pp. 432-439
Journal of Allergy and Clinical Immunology, 149, 432-439
Journal of Allergy and Clinical Immunology, 149(1), 432-439.e4. MOSBY-ELSEVIER
Journal of Allergy and Clinical Immunology, 149(1), 432-439.e4. Mosby Inc.

Background: A novel autoinflammatory syndrome was recently described in male patients who harbored somatic mutations in the X-chromosomal UBA1 gene. These patients were characterized by adult-onset, treatment-refractory inflammation with fever, cytop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e1545a39943a56b7d8eb1c62781215
https://repository.ubn.ru.nl/handle/2066/246773