A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid β and elicits antibodies against oligomeric and fibrillar amyloid and plaques.

Autor: Peter Hoogerhout, Willem Kamphuis, Humphrey F Brugghe, Jacqueline A Sluijs, Hans A M Timmermans, Janny Westdijk, Gijsbert Zomer, Claire J P Boog, Elly M Hol, Germie P J M van den Dobbelsteen

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e19110 (2011)

The 39- to 42-residue amyloid β (Aβ) peptide is deposited in extracellular fibrillar plaques in the brain of patients suffering from Alzheimer's Disease (AD). Vaccination with these peptides seems to be a promising approach to reduce the plaque loa

Externí odkaz: https://doaj.org/article/7791c9bbd1bf44848d903f4836db19d3

Solid-phase synthesis and application of double-fluorescent-labeled lipopeptides, containing a CTL-epitope from the measles fusion protein:.

Autor: Hoogerhout, P.¹, Stittelaar, K.J.², Brugghe, H.F.¹, Timmermans, J.A.M.¹, ten Hove, G.J.³, Jiskoot, W.⁴, Hoekman, J.H.G.⁵, Roholl, P.J.M.⁵

Publikováno v: Journal of Peptide Research. Nov99, Vol. 54 Issue 5, p436-443. 8p.

Vaccination Prevented Short-Term Memory Loss, but Deteriorated Long-Term Spatial Memory in Alzheimer’s Disease Mice, Independent of Amyloid-ß Pathology

Autor: Oberman, Klaske, Gouweleeuw, Leonie, Hoogerhout, Peter, Eisel, Ulrich L.M., van Riet, Elly, Schoemaker, Regien G.

Publikováno v: Journal of Alzheimer's Disease Reports; June 2020, Vol. 4 Issue: 1 p261-280, 20p

Vaccination Prevented Short-Term Memory Loss, but Deteriorated Long-Term Spatial Memory in Alzheimer's Disease Mice, Independent of Amyloid-β Pathology.

Autor: Oberman K; Department of Neurobiology GELIFES, University Groningen, The Netherlands., Gouweleeuw L; Department of Neurobiology GELIFES, University Groningen, The Netherlands., Hoogerhout P; INTRAVACC, Bilthoven, The Netherlands., Eisel ULM; Department of Neurobiology GELIFES, University Groningen, The Netherlands., van Riet E; INTRAVACC, Bilthoven, The Netherlands., Schoemaker RG; Department of Neurobiology GELIFES, University Groningen, The Netherlands.; University Medical Center Groningen, The Netherlands.

Publikováno v: Journal of Alzheimer's disease reports [J Alzheimers Dis Rep] 2020 Jul 23; Vol. 4 (1), pp. 261-280. Date of Electronic Publication: 2020 Jul 23.

Effecten van synthetische IgE-afgeleide peptiden en anti-IgE conjugaatvaccins in het cardiovasculaire systeem van de rat

Autor: Wemer J, Vleeming W, Hoogerhout P, Poolman JT, TOX, BVM

In anaphylactic reactions IgE-mediated effects on the pulmonary and cardiovascular system play a pivotal role. The sequence of amino acids of the chains of the IgE-antibody is known and decapeptides can be synthesized resembling that part of the chai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::8cddf047cdd8b25b5e9c2004f190d2db
http://hdl.handle.net/10029/257155