Kupffer cell release of platelet activating factor drives dose limiting toxicities of nucleic acid nanocarriers

Autor: Jackson, Meredith A., Patel, Shrusti S., Yu, Fang, Cottam, Matthew A., Glass, Evan B., Hoogenboezem, Ella N., Fletcher, R. Brock, Dollinger, Bryan R., Patil, Prarthana, Liu, Danielle D., Kelly, Isom B., Bedingfield, Sean K., King, Allyson R., Miles, Rachel E., Hasty, Alyssa M., Giorgio, Todd D., Duvall, Craig L.

Publikováno v: In Biomaterials January 2021 268

Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes

Autor: Jackson, Meredith A., Bedingfield, Sean K., Yu, Fang, Stokan, Mitchell E., Miles, Rachel E., Curvino, Elizabeth J., Hoogenboezem, Ella N., Bonami, Rachel H., Patel, Shrusti S., Kendall, Peggy L., Giorgio, Todd D., Duvall, Craig L.

Publikováno v: In Biomaterials February 2019 192:245-259

Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis

Autor: Colazo, Juan M., Hoogenboezem, Ella N., Shah, Veeraj, Yu, Fang, Lo, Justin H., Sorets, Alexander G., Francini, Nora, Cho, Hongsik, Michell, Danielle L., Vickers, Kasey C., Gibson-Corley, Katherine N., Hasty, Karen A., Crofford, Leslie, Cook, Rebecca S., Duvall, Craig L.

Publikováno v: bioRxiv

Osteoarthritis ( OA ) and rheumatoid arthritis ( RA ) are joint diseases that are associated with pain and lost quality of life. No disease modifying OA drugs are currently available. RA treatments are better established but are not always effective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::47a9919f0275b0a182987debd2a2f050
https://europepmc.org/articles/PMC10274717/

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Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system.

Autor: Sorets AG; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Schwensen KR; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Francini N; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Kjar A; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Abdulrahman AM; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Shostak A; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Katdare KA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA., Schoch KM; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Cowell RP; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Park JC; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Ligocki AP; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Ford WT; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Ventura-Antunes L; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Hoogenboezem EN; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Prusky A; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Castleberry M; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Michell DL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Miller TM; Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Vickers KC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Schrag MS; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Duvall CL; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Lippmann ES; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 07. Date of Electronic Publication: 2024 Sep 07.