Výsledky vyhledávání - "Hoogduijn, Martin J."

Akademický článek

The immunomodulatory properties of messenchymal stem cells and their use for immunotherapy.

Autor: Hoogduijn, Martin J., Popp, F., Verbeek, R., Masoodi, Mojgan, Nicolaou, Anna, Baan, C., Dehlke, M-H.

There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless

Externí odkaz: http://hdl.handle.net/10454/4576

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Akademický článek

Melanin protects melanocytes and keratinocytes against H2O2-induced DNA strand breaks through its ability to bind Ca2+

Autor: Hoogduijn, Martin J., Cemeli, Eduardo, Ross, K., Anderson, Diana, Thody, Anthony J., Wood, John M.

Reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) are produced in the skin under the influence of UV radiation. These compounds are highly reactive and can induce DNA lesions in epidermal cells. Melanin is considered to protect human ski

Externí odkaz: http://hdl.handle.net/10454/2311

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Akademický článek

Melanin has a role in Ca2+ homeostasis in human melanocytes

Autor: Wood, John M., Hoogduijn, Martin J., Smit, N.P., Thody, Anthony J., Van Der Laarse, A., Van Nieuwpoort, A.F.

We have examined whether melanin affects Ca2+ homeostasis in cultured normal human melanocytes. Intracellular Ca2+ concentrations ([Ca2+]i), were measured in four Caucasian and in three Negroid melanocyte cultures. Under resting conditions [Ca2+]i wa

Externí odkaz: http://hdl.handle.net/10454/4126

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Akademický článek

Melanosomal pH controls rate of melanogenesis, eumelanin/phaeomelanin ratio and melanosome maturation in melanocytes and melanoma cells.

Autor: Ancans, Janis, Tobin, Desmond J., Hoogduijn, Martin J., Smit, N.P., Wakamatsu, K., Thody, Anthony J.

The skin pigment melanin is produced in melanocytes in highly specialized organelles known as melanosomes. Melanosomes are related to the organelles of the endosomal/lysosomal pathway and can have a low internal pH. In the present study we have shown

Externí odkaz: http://hdl.handle.net/10454/3681

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