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Targeted Regulation and Cellular Imaging of Tumor-Associated Macrophages in Triple-Negative Breast Cancer: From New Mechanistic Insights to Candidate Translational Applications

Autor: Anupama, Hooda-Nehra, L., Smith, Tracey, I., Ferrer, Alejandra, I., Staquicini, Fernanda, Wadih, Arap, Renata, Pasqualini, Pranela, Rameshwar

Publikováno v: Macrophages-Celebrating 140 Years of Discovery ISBN: 9781803556246
Macrophages-Celebrating 140 Years of Discovery

The complex interplay between immune cells and tumor cells within the tumor microenvironment (TME) can lead to disease progression. Specifically, signals generated in the TME can cause immunosuppression, promoting angiogenesis and immune evasion, whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8590599bfaccf0e80fb933725d0d3125
https://doi.org/10.5772/intechopen.105654

Translational Modeling Identifies Synergy between Nanoparticle-Delivered miRNA-22 and Standard-of-Care Drugs in Triple Negative Breast Cancer

Autor: Joseph D. Butner, Wadih Arap, Vittorio Cristini, Bulent Ozpolat, Javier Ruiz Ramírez, Anupama Hooda-Nehra, George A. Calin, Renata Pasqualini, Prashant Dogra, María J. Peláez, Caroline Chung, Zhihui Wang

The downregulation of miRNA-22 in triple negative breast cancer (TNBC) is associated with upregulation of eukaryotic elongation 2 factor kinase (eEF2K) protein, which regulates tumor growth, chemoresistance, and tumor immunosurveillance. Moreover, ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b34241430b9a8ed4514b8d1ae49488c1
https://doi.org/10.1101/2021.10.19.21265154

NFĸB Targeting in Bone Marrow Mesenchymal Stem Cell-Mediated Support of Age-Linked Hematological Malignancies

Autor: Jean-Pierre Etchegaray, Shyam A. Patel, Marianne D. Castillo, Anupama Hooda-Nehra, Rachel Unkovic, Marcelo Taborga, Joshua Kra, Shaun Patterson, Pranela Rameshwar, Mohammed Jaloudi, Victor T. Chang, Lauren S. Sherman, Marina Gergues, Darling P. Rojas

Publikováno v: Stem cell reviews and reports. 17(6)

Mesenchymal stem cells (MSCs) can become dysfunctional in patients with hematological disorders. An unanswered question is whether age-linked disruption of the bone marrow (BM) microenvironment is secondary to hematological dysfunction or vice versa.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf3074af3a0234b091de7512a47a3cd
https://pubmed.ncbi.nlm.nih.gov/34410592

Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer

Autor: Wouter H. P. Driessen, Anupama Hooda-Nehra, Wadih Arap, Prashant Dogra, Massimo Cristofanilli, Diana N. Nunes, Vittorio Cristini, Emmanuel Dias-Neto, Martin Trepel, Javier Ruiz-Ramírez, Robin L. Anderson, Fernanda I. Staquicini, Zhihui Wang, Marina Cardó-Vila, Gabriel Hortobagy, Juri G. Gelovani, Zaver M. Bhujwalla, Stephen K. Burley, Daniela I. Staquicini, Mauro Cortez, Amin Hajitou, Renata Pasqualini, Bettina Proneth, Maria Hoh, Richard L. Sidman, Mohammed Jaloudi, Bedrich L. Eckhardt, Israel Tojal da Silva, Jaqueline Ramalho Buttura, Christopher Markosian

Publikováno v: eLife 10:e65145 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
eLife, Vol 10 (2021)
eLife

Triple-negative breast cancer (TNBC) is an aggressive tumor with limited treatment options and poor prognosis. We applied the in vivo phage display technology to isolate peptides homing to the immunosuppressive cellular microenvironment of TNBC as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73436bf8d1cd5ee6fbdffb570a71f32b
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=62213